2 results match your criteria: "Southern Medical University (Longhua People's Hospital) Shenzhen 518109[Affiliation]"
With the development of biotechnology, biomaterials have been rapidly developed and shown great potential in bone regeneration therapy and bone tissue engineering. Nanoparticles have attracted the attention of researches and have applied in various fields especially in the biomedical field as the special physicochemical properties. Nanoparticles were found to regulate bone remodeling depending on their size, shape, composition, and charge.
View Article and Find Full Text PDFMitochondrial phosphoenolpyruvate carboxykinase inhibits kidney renal clear cell carcinoma malignant progression, leading to cell energy metabolism imbalance.
Am J Cancer Res
March 2023
Department of Urology, Affiliated Longhua People's Hospital, Southern Medical University (Longhua People's Hospital) Shenzhen 518109, Guangdong, China.
Article Synopsis
- Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) plays a critical role in gluconeogenesis and is differentially expressed in kidney renal clear cell carcinoma (KIRC), potentially affecting energy metabolism and cancer progression.* -
- Research showed that lower PCK2 levels in KIRC patients correlated with shorter survival times, and experiments confirmed that overexpressing PCK2 hindered KIRC cell growth, migration, and invasion while enhancing energy metabolism.* -
- The findings suggest PCK2 could be a valuable diagnostic and prognostic biomarker for KIRC and may represent a promising therapeutic target in treating this type of cancer.*