Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Index: Findings From PARADIGM-HF and PARAGON-HF.

Background: The importance of nutritional status is underappreciated in patients with heart failure (HF). This study aimed to describe the range of the prognostic nutrition index (PNI), and the clinical characteristics and outcomes according to PNI, in patients with HF with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The primary outcome was the composite of HF hospitalization or cardiovascular death.

RBM15 increase tumor-infiltrating CD4+ T cell in ESCC modulating of PLOD3.

Background: Collagen, a primary protein component of the extracellular matrix (ECM), undergoes a notable series of alterations concomitant with the growth of the tumor. Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3) is involved in the synthesis of collagen and has been associated with a variety of cancers. However, it is unclear how PLOD3 functions in esophageal squamous cell carcinoma (ESCC).

A dual-locked cyclopeptide-siRNA conjugate for tumor-specific gene silencing.

Strategies allowing tumor-selective siRNA delivery while minimizing off-tumor gene silencing effects are highly demanded to advance cancer gene therapy, which however still remain challenging. We herein report a dual-locking bioconjugation approach to address this challenge. A dual-locked cyclopeptide-siRNA conjugate (DPRC) was designed to simultaneously endow siRNA with tumor-targeting properties and tumor-biomarker/visible-light dually controllable action.

Exploring the Relationship Between Gut Microbiota and Sarcopenia Based on Gut-Muscle Axis.

Sarcopenia, as a disease characterized by progressive decline of quality, strength, and function of muscles, has posed an increasingly significant threat to the health of middle-aged and elderly individuals in recent years. With the continuous deepening of studies, the concept of gut-muscle axis has attracted widespread attention worldwide, and the occurrence and development of sarcopenia are believed to be closely related to the composition and functional alterations of gut microbiota. In this review, combined with existing literatures and clinical reports, we have summarized the role and impacts of gut microbiota on the muscle, the relevance between gut microbiota and sarcopenia, potential mechanisms of gut microbiota in the modulation of sarcopenia, potential methods to alleviate sarcopenia by modulating gut microbiota, and relevant advances and perspectives, thus contributing to adding more novel knowledge to this research direction and providing certain reference for future related studies.

Coexisting nutcracker phenomenon and refractory hypertension in a patient with IgA nephropathy: A case report and literature review.

The entrapment of the left renal vein (LRV) may contribute to changes in hemodynamics within kidney and could also be associated with IgA nephropathy (IgAN). Although the relationship between the nutcracker phenomenon and IgAN has not yet been elucidated, it is speculated that this patient's refractory hypertension is a combined effect of nutcracker syndrome (NCS) and IgAN.

Upconversion nanoparticles incorporated with three-dimensional graphene composites for electrochemical sensing of baicalin from natural plants.

Chinese medicine has been widely studied owing to its many advantages. Baicalin (Bn), extracted from natural plants, has been shown to have significant anti-inflammatory and anticancer activity. Therefore, it is of great significance to develop a suitable method to detect the content of Bn in traditional Chinese medicine.

Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study.

Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort study included 1138 patients with compensated cirrhosis (median follow-up of 40.

Metabolic regulation of intestinal homeostasis: molecular and cellular mechanisms and diseases.

Metabolism serves not only as the organism's energy source but also yields metabolites crucial for maintaining tissue homeostasis and overall health. Intestinal stem cells (ISCs) maintain intestinal homeostasis through continuous self-renewal and differentiation divisions. The intricate relationship between metabolic pathways and intestinal homeostasis underscores their crucial interplay.

A three-dimensional lead iodide perovskite analog featuring hydrogen-bonded dual monovalent cations.

Three-dimensional (3D) halide perovskites have attracted considerable research interest, yet the selection of A-site cations is restricted by the Goldschmidt tolerance factor. To accommodate cations beyond this acceptable range, novel 3D perovskite analog structures with edge- and face-sharing motifs have been developed. Until now, these structures have been limited to divalent cations due to significant electrostatic repulsion when incorporating two monovalent cations.

Photothermal responsive porous hollow microneedles as Chinese medicine versatile delivery system for wound healing.

Chinese medicine is identified as a candidate for wound healing. Attempts in this field tend to develop efficient dosage forms for delivering Chinese medicine with low side effects. In this paper, we proposed novel photothermal responsive porous hollow microneedles (PRPH-MNs) as a versatile Chinese medicine delivery system for efficient antibacterial wound treatment.

Developing functional hydrogels for treatment of oral diseases.

Oral disease is a severe healthcare challenge that diminishes people's quality of life. Functional hydrogels with suitable biodegradability, biocompatibility, and tunable mechanical properties have attracted remarkable interest and have been developed for treating oral diseases. In this review, we present up-to-date research on hydrogels for the management of dental caries, endodontics, periapical periodontitis, and periodontitis, depending on the progression of dental diseases.

Stabilizing ultra-close Pt clusters on all-in-one CeO/AlO fibril-in-tubes against sintering.

Metal sintering poses significant challenges for developing reliable catalytic systems toward high-temperature reactions, particularly those based on metal clusters with sizes below 3 nm. In this work, electrospun dual-oxide fibril-in-tubes consisting of CeO and AlO are rationally designed in an all-in-one manner, to stabilize 2.3 nm Pt clusters with a Tammann temperature (sintering onset temperature) lower than 250 °C.

The H/F substitution strategy can achieve large spontaneous polarization in 1D hybrid perovskite ferroelectrics.

Hybrid organic-inorganic perovskite (HOIP) ferroelectrics exhibit polarization reversibility and have a wide range of applications in the fields of smart switches, memorizers, sensors, However, the inherent limitations of small spontaneous polarization ( ) and large coercive field ( ) in ferroelectrics have impeded their broader utilization in electronics and data storage. Molecular ferroelectrics, as a powerful supplement to inorganic ferroelectrics, have shown great potential in the new generation of flexible wearable electronic devices. The important research responsibility is to greatly improve progressiveness and overcome the above limitations.

Encapsulated TADF macrocycles for high-efficiency solution-processed and flexible organic light-emitting diodes.

Macrocyclic thermally activated delayed fluorescence (TADF) emitters have been demonstrated to realize high efficiency OLEDs, but the design concept was still confined to rigid π-conjugated structures. In this work, two macrocyclic TADF emitters, Cy-BNFu and CyEn-BNFu, with a flexible alkyl chain as a linker and bulky aromatic hydrocarbon wrapping units were designed and synthesized. The detailed photophysical analysis demonstrates that the flexible linker significantly enhances the solution-processibility and flexibility of the parent TADF core without sacrificing the radiative transition and high PLQY.

Effects of low-frequency pulsed electrical stimulation at the common peroneal nerve on chronic refractory wounds of the lower limb: A randomized controlled trial.

Background And Aims: Electrical stimulation (ES) has been shown to substantially enhance the quality of life by alleviating pain in patients with chronic wounds. This study aimed to observe the effects of low-frequency pulsed wearable ES at the common peroneal nerve on chronic refractory wounds of the lower limb.

Methods: Forty-eight participants were randomly divided into control group ( = 24) and treatment group ( = 24) in this study.

A novel extraction method for three ochratoxins in human urine based on polystyrene/polyethersulfone electrospun nanofibers coated with copper nanoparticles.

In this study, four types of nanofibers were prepared electrospinning and characterized through SEM, TEM, EDS, FTIR, TG, XPS and water contact angle analyses, and the novel polystyrene/polyethersulfone nanofibers coated with copper nanoparticles (PS/PES-CuNPs nanofibers) were developed as an ideal adsorbent for the extraction of three ochratoxins from human urine. The solid-phase extractant of sample pretreatment displayed preferable sensitivity and an extraction effect, and the analytical method based on the novel packed-fiber solid-phase extraction strategy followed by high performance liquid chromatography-fluorescence detection (PFSPE-HPLC-FLD) achieved an exceedingly low limit of detection (LOD) and limit of quantification (LOQ) of 0.108-0.

Machiavellianism: Psychological, Clinical, and Neural Correlations.

Machiavellianism is a personality trait that denotes cunning, manipulative ability, and a desire to gain power by any possible means. Machiavellianism is a subclinical form of psychopathy that has an impact on individual health, professional settings and social order. Machiavellians are more at risk of developing anxiety and depression; however, the underpinning mechanism has not been studied clearly.