A conjugated porous triazine-linked polyimide host with dual confinement of polysulfides for high-performance lithium-sulfur batteries.

In the quest for next-generation energy storage solutions, lithium-sulfur (Li-S) batteries present exceptional potential due to their high energy density and cost-effectiveness. Nevertheless, significant challenges, such as the shuttle effect of lithium polysulfides (LiPSs) and inadequate sulfur utilization, have impeded their practical application. In this study, we report the design and synthesis of a novel covalent organic polymer that integrates a triazine-linked framework with carbonyl-enriched polyimide moieties, serving as a highly effective sulfur host for Li-S batteries.

Receptor binding and structural basis of raccoon dog ACE2 binding to SARS-CoV-2 prototype and its variants.

Raccoon dog was proposed as a potential host of SARS-CoV-2, but no evidence support such a notion. In our study, we investigated the binding affinities of raccoon dog ACE2 (rdACE2) to the spike (S) protein receptor binding domain (RBD) of SARS-CoV-2 prototype (PT) and its variants. It revealed that the binding affinities of RBD from SARS-CoV-2 variants were generally lower than that of the PT RBD.

Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution.

The anterior cingulate cortex (ACC) of the human brain is involved in higher-level cognitive functions such as emotion and self-awareness. We generated profiles of human and macaque ACC gene expression and chromatin accessibility at single-nucleus resolution. We characterized the conserved patterns of gene expression, chromatin accessibility, and transcription factor binding in different cell types.

Shielding the Hägg carbide by a graphene layer for ultrahigh carbon efficiency during syngas conversion.

Fischer-Tropsch synthesis represents a key endeavor aimed at converting nonpetroleum carbon resources into clean fuels and valuable chemicals. However, the current state-of-the-art industrial FTS employing Fe-based catalysts is still challenged by the low carbon efficiency (<50%), mainly attributed to the prominent formation of CO and CH resulting from the nonregulated side water gas shift reaction. Herein, we describe a shielding strategy involving the encapsulation of the active Hägg carbide (χ-FeC) by a graphene layer, exhibiting excellent resilience under reaction conditions and exposure to air, thereby eliminating the need for reduction or activation before the Fischer-Tropsch synthesis reaction.

Photochemical upcycling of polymers visible light-driven C-H bond activation.

The excessive use and improper disposal of plastics have placed a significant burden on the environment. To mitigate this impact, prioritizing the chemical upcycling of plastics is crucial. Unlike traditional thermochemical upcycling, which requires harsh conditions such as high temperatures and pressures, photochemical upcycling is viewed as a more environmentally friendly and cost-effective alternative.

Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway.

This study aimed to evaluate the therapeutic properties of the traditional Chinese medicine Xuesanqi (XSQ, from the rhizome of Polygonum amplexicaule D. Don) in treating ulcerative colitis. We hypothesized that its many active components can alleviate symptoms of colitis by regulating the gut microbiota, its metabolites, and various signaling pathways.

Caragana jubata ethanol extract ameliorates the symptoms of STZ-HFD-induced T2DM mice by PKC/GLUT4 pathway.

Ethnopharmacological Relevance: Caragana jubata (Pall.) Poir., a traditional Tibetan medicinal plant in China, is renowned in Tibetan medicine for its hypoglycemic properties and long-standing use in treating diabetes.

Discrimination of wild edible and poisonous fungi with similar appearance (Cantharellus albovenosus vs Omphalotus olearius) based on lipidomics using UHPLC-HR-AM/MS/MS.

Mushrooms have long been appreciated as a delicacy as well as used as vital dietary supplements and food. However, poisoning from mushroom consumption remains a worldwide health problem, resulting in morbidity and mortality. In this paper, for the first time an untargeted lipidomics analysis on Omphalotus olearius (O.

A neural circuit from paratenial thalamic nucleus to anterior cingulate cortex for the regulation of opioid-induced hyperalgesia in male rats.

Prolonged use of opioids can lead to increased sensitivity to painful stimuli, a condition referred to as opioid-induced hyperalgesia (OIH). However, the mechanisms underlying this contradictory situation remain unclear. This study elucidates the pivotal role of the paratenial thalamic nucleus (PT)-anterior cingulate cortex (ACC) neuronal circuit in the development of OIH in male rats.

Loss of Brcc3 in Zebrafish Embryos Increases Their Susceptibility to DNA Damage Stress.

DNA double-strand breaks (DSBs) represent one of the most severe forms of genetic damage in organisms, yet vertebrate models capable of monitoring DSBs in real-time remain scarce. BRCA1/BRCA2-containing complex subunit 3 (BRCC3), also known as BRCC36, functions within various multiprotein complexes to mediate diverse biological processes. However, the physiological role of BRCC3 in vertebrates, as well as the underlying mechanisms that govern its activity, are not well understood.

Quantitative analysis of dried serum FTIR spectra based on correlation Analysis-Interval random Frog-Partial least squares.

Serum biochemical markers are widely used in clinical practice but often require expensive, specific reagents, complex instruments, and prolonged result waiting times. Infrared spectroscopy offers multiple advantages for serum analysis, such as reagent-free testing and the ability to quickly and directly measure multiple parameters simultaneously. This study collected serum samples from 66 healthy subjects to explore the relationship between dried serum infrared spectra and biochemical parameters, and to investigate the feasibility of simultaneously quantifying nine major serum components using dried serum infrared spectra.

Synthesis and preclinical evaluation of diarylamine derivative as Tau-PET radiotracer for Alzheimer's Disease.

The presence of aggregated Tau in the brain is a dominant pathological hallmark of Tauopathies, particularly in Alzheimer's disease (AD). Therefore, developing ligands that can specifically and sensitively bind to Tau aggregates is essential for diagnosing and monitoring therapeutic interventions. In this study, we further investigated the structural optimization of the diarylamine skeleton, which exhibited promising binding characteristics and biological properties.

Advanced Preparation Methods and Biomedical Applications of Single-Atom Nanozymes.

Metal nanoparticles with inherent defects can harness biomolecules to catalyze reactions within living organisms, thereby accelerating the advancement of multifunctional diagnostic and therapeutic technologies. In the quest for superior catalytic efficiency and selectivity, atomically dispersed single-atom nanozymes (SANzymes) have garnered significant interest recently. This review concentrates on the development of SANzymes, addressing potential challenges such as fabrication strategies, surface engineering, and structural characteristics.

Identification and prediction of the degree of multidimensional returning to poverty risk for the household in China through the novel hybrid model: Based on the survey data of China Family Panel Studies (CFPS).

In China, absolute poverty has been effectively eliminated, but this does not signify the complete eradication of poverty. Instead, poverty persists in the forms of relative and secondary poverty. More concerningly, regions or households lifted out of poverty continue to face numerous risks of returning to poverty.

Anti-inflammatory mechanism of Houttuynia cordata polysaccharides against ulcerative colitis based on multi-omics conjoint analysis.

The Houttuynia cordata polysaccharide (HCP) was extracted from the traditional Chinese medicine, Houttuynia cordata, known for its anti-inflammatory properties. It has an acidic heteropolysaccharide with a molecular weight of approximately 13.38 kDa, consisting of 7 monosaccharides such as galactose, galacturonic acid, and glucose.

Swertiamarin ameliorates type 2 diabetes by activating ADRB3/UCP1 thermogenic signals in adipose tissue.

Background And Purpose: Swertiamarin (STM), a secoiridoid glycoside from Swertia chirayita (Roxb.) H. Karst, has been shown to decrease body weight, blood glucose, and blood lipids by inhibiting adipose tissue hypertrophy.

Circular RNA as Diagnostic and Prognostic Biomarkers in Hematological Malignancies:Systematic Review.

While various serum and tissue biomarkers have been explored for tumor diagnosis, the sensitivity and specificity have not yield optimal results. Circular RNAs (circRNAs) are more stable, conserved, and tissue-specific than linear RNA. Recent reports indicate that circRNAs could serve as potential biomarkers in the diagnosis or/and prognosis of tumors.

A novel α-mangostin derivative synergistic to antibiotics against MRSA with unique mechanisms.

Methicillin-resistant (MRSA) remains a leading cause of hospital-acquired infections, often linked to complicated treatments, increased mortality risk, and significant cost burdens. Several antibacterial agents have been developed to address MRSA resistance. In this study, potential agents to combat MRSA resistance were explored, with the antibacterial activity of synthesized α-mangostin (α-MG) derivatives being evaluated alongside investigations into their cellular mechanisms against MRSA2.

Triple-shelled Ni@MnO/C hollow spheres with enhanced performance for rechargeable zinc-ion capacitors.

Electrochemical activation techniques and the use of multi-shell structured materials are effective strategies to enhance the electrochemical performance of rechargeable aqueous zinc-ion capacitors (ZICs). In this study, we successfully synthesized spherical NiMn-MOFs a solvothermal method and used them as templates to prepare Ni/MnO@C nanospheres with different core-shell structures by adjusting the heating rate under an Ar atmosphere. The multi-shelled structure provides more active sites and alleviates structural strain associated with repeated Zn insertion/extraction processes.

Transition-metal-free photochemical reductive denitration of nitroarenes.

We have developed a simple and mild photochemical process for the reductive denitration of nitroarenes under transition-metal-free conditions. This method is compatible with a broad range of functional groups, providing a practical and efficient approach for converting nitroarenes into denitrated arenes. The utility of this protocol is demonstrated through the prompt synthesis of dibenzoxepane.