Synergistic Enhancing of Biological Activity and Natural Light Self-Degradation of Organic-Inorganic Hybrid Nano-organometallic Pesticide-Fused Phenylpyrazole Amine Derivatives with Hollow Box TiO by One-pot Microwave Synthesis.

Nano-TiO as an antimicrobial inorganic material, can stimulate cells to produce reactive oxygen species and exhibit effective biochemical properties; however, phenylpyrazole derivatives, as organic pesticides, are widely used in agriculture and food. To find novel pesticides with environmental friendliness, combined with three-dimensional quantitative structure-activity relationship (3D-QSAR) prediction analysis, three types of alkaloidal phenylpyrazole amine derivatives (PA) were synthesized by a one-pot microwave method. Based on the dye sensitization strategy, four nano-organometallic pesticides (PT) were prepared by organic-inorganic hybridization.

Multiple optical path length reflections enhancement based on balloon-type photoacoustic cell for trace gas sensing.

A novel balloon-type photoacoustic cell (BTPAC) is proposed to facilitate the detection limitations of acetylene (CH) gas achieving ppb level. Here, an ellipsoidal photoacoustic cavity is employed as the platform for gas-light interaction. By strategically directing the excitation source towards the focal point of the ellipsoidal cavity, ensuring its trajectory traverses the focal point upon each reflection from the interior walls.

Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter-3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex.

Cannabinoid receptor 1 (CB1) regulates synaptic transmission through presynaptic receptors in nerve terminals, and its physiological roles are of clinical relevance. The cellular sources and synaptic targets of CB1-expressing terminals in the human cerebral cortex are undefined. We demonstrate a variable laminar pattern of CB1-immunoreactive axons and electron microscopically show that CB1-positive GABAergic terminals make type-2 synapses innervating dendritic shafts (69%), dendritic spines (20%) and somata (11%) in neocortical layers 2-3.

An Autonomous Positioning Method for Drones in GNSS Denial Scenarios Driven by Real-Scene 3D Models.

Drones are extensively utilized in both military and social development processes. Eliminating the reliance of drone positioning systems on GNSS and enhancing the accuracy of the positioning systems is of significant research value. This paper presents a novel approach that employs a real-scene 3D model and image point cloud reconstruction technology for the autonomous positioning of drones and attains high positioning accuracy.

Hantaan virus glycoprotein Gc induces NEDD4-dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation.

Hantaan virus (HTNV) infection causes severe hemorrhagic fever with renal syndrome (HFRS) in humans and the infectious process can be regulated by autophagy. The phosphatase and tensin homolog (PTEN) protein has antiviral effects and plays a critical role in the autophagy pathway. However, the relationship between PTEN and HTNV infection is not clear and whether PTEN-regulated autophagy involves in HTNV replication is unknown.

Oligosaccharide-assisted resolution of holothurian fucosylated chondroitin sulfate for fine structure and P-selectin inhibition.

Fucosylated chondroitin sulfate (FCS) from Holothuria mexicana (FCS) was selected for investigation because of its intriguing branch features. Selective β-eliminative depolymerization and the bottom-up assembly were performed to unravel that FCS consisted of a {D-GlcA-β1,3-D-GalNAc} backbone and branches of alternating Fuc (55 %) and D-GalNAc-α1,2-L-Fuc (45 %), the highest proportion of disaccharide branch reported to date. In branches, sulfation could occur at every free -OH site except O-3 of GalNAc, being the most complex and various structure features of natural FCS.

Comparative Transcriptome Analysis Highlights the Role of in the Honeydew Production of Virulent Brown Planthoppers ( Stål) to Resistant Rice Variety.

Brown planthoppers (BPHs, Stål) are a major threat to rice cultivation in Asia, necessitating the development of pest-resistant varieties for effective management. However, the adaptability of BPHs has resulted in the development of virulent populations, such as biotype Y BPHs, which exhibit significant virulence against the rice variety YHY15 that harbors the resistance gene . The various response mechanisms of BPH populations to resistant rice varieties are critical yet underexplored.

Tumor Metabolic Reprogramming and Ferroptosis: The Impact of Glucose, Protein, and Lipid Metabolism.

Ferroptosis, a novel form of cell death discovered in recent years, is typically accompanied by significant iron accumulation and lipid peroxidation during the process. This article systematically elucidates how tumor metabolic reprogramming affects the ferroptosis process in tumor cells. The paper outlines the basic concepts and physiological significance of tumor metabolic reprogramming and ferroptosis, and delves into the specific regulatory mechanisms of glucose metabolism, protein metabolism, and lipid metabolism on ferroptosis.

Stochastic Gradient Descent for Kernel-Based Maximum Correntropy Criterion.

Maximum correntropy criterion (MCC) has been an important method in machine learning and signal processing communities since it was successfully applied in various non-Gaussian noise scenarios. In comparison with the classical least squares method (LS), which takes only the second-order moment of models into consideration and belongs to the convex optimization problem, MCC captures the high-order information of models that play crucial roles in robust learning, which is usually accompanied by solving the non-convexity optimization problems. As we know, the theoretical research on convex optimizations has made significant achievements, while theoretical understandings of non-convex optimization are still far from mature.

Catalytic asymmetric C-N cross-coupling towards boron-stereogenic 3-amino-BODIPYs.

3-Amino boron dipyrromethenes (BODIPYs) are a versatile class of fluorophores widely utilized in live cell imaging, photodynamic therapy, and fluorescent materials science. Despite the growing demand for optically active BODIPYs, the synthesis of chiral 3-amino-BODIPYs, particularly the catalytic asymmetric version, remains a challenge. Herein, we report the synthesis of boron-stereogenic 3-amino-BODIPYs via a palladium-catalyzed desymmetric C-N cross-coupling of prochiral 3,5-dihalogen-BODIPYs.

Magnetic fields improve the gel properties of myofibrillar proteins in low-salt myofibrillar protein emulsion systems.

The effect of magnetic field on the properties of emulsified gels containing myofibrillar protein (MP-emulsified gels) with different salt concentration (0, 0.2, 0.4, 0.

Does the coupling of digital and green technology innovation matter for carbon emissions?

The global situation of carbon reduction is very severe, and the coupling of digital and green technology innovation is one of the most significant approaches to promoting regional low-carbon transformation. A coupling evaluation model is employed to assess the coupling index between digital technology innovation and green technology innovation in China's 30 provinces from 2011 to 2021. The STIRPAT model is used to examine the impact of the increasing coupling index on carbon emissions, as well as its spatial effects, and heterogeneity.

Photoelectrochemical aptasensing and fluorescence imaging co-joint detecting MCF-7 cells in whole blood via an inertial separation microfluidic chip.

The mortality rate of tumor is still very high till now. Circulating tumor cells (CTCs) are the major culprit of high cancer mortality. To improve survival rate of cancer patients, real-time monitoring and quantitative detection of CTCs are of indescribable value.

Design, synthesis, and characterization of an Ag-Bi-S-based multifunctional nanotheranostic platform.

This paper reports an Ag-Bi-S-based nanotheranostic platform with an ingeniously designed heterostructure, an appropriate size, and good imaging and therapy performances. By comparing the fluorescence property and Bi element content, the optimal heterostructure was demonstrated to be AgS/BiS core/shell. The hydrophilic AgS/BiS-PEG nanocrystals with hydrodynamic diameter of 37.

Genetic variation in Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis.

Heat interferes with multiple meiotic processes, leading to genome instability and sterility in flowering plants, including many crops. Despite its importance for food security, the mechanisms underlying heat tolerance of meiosis are poorly understood. In this study, we analyzed different meiotic processes in the Arabidopsis (Arabidopsis thaliana) accessions Col and Ler, their F1 hybrids, and the F2 offspring under heat stress (37 °C).

Discovery of xanthone-based nitric oxide donors targeting biofilm clearance.

Bacteria biofilm infection seriously challenges clinical drug therapy. Nitric oxide (NO) was reported to disperse biofilm, eliminate bacteria resistance and kill bacteria. In this study, on the basis of membrane targeting of α-mangostin (α-MG) and the dispersion effect of NO on bacteria biofilms, we designed and synthesized 30 NO donors that α-MG was conjugated with a nitrobenzene or a nitrate and other four representative reference derivatives.

Pulmonary toxicity assessment of tumor necrosis factor α inhibitors in the treatment of IBD: a real world study based on US food and drug administration adverse events reporting system (FAERS).

Background: Tumor necrosis factor α (TNF-α) inhibitors are widely used in the treatment of inflammatory bowel disease (IBD), but there is still a lack of systematic risk assessment for pulmonary toxicity.

Methods: We calculated the pulmonary-related risk signals for four TNF-α inhibitors using the disproportionality analysis and also compared them with the pulmonary-related signals of seven other therapies.

Results: There were 8736 reports of pulmonary-related adverse events (AEs) to TNF-α inhibitors as the 'primary suspect (PS)' therapies.

Characterization and structural analysis of a leucine aminopeptidase using site-directed mutagenesis.

Amp0279 (EC 3.4.11.

Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4.

Background: Artemisia argyi is a well-known medicinal plant. A. argyi has been widely used in clinical for about 3000 years, owing to its extensive pharmacological activity.

Five brasilane-type sesquiterpenoids with neuroprotective activities from Xylaria nigripes.

Five brasilane-type sesquiterpenoids, including four previously undescribed compounds named xylaribrasilaids A-D, along with a known analogue, were isolated from the ethyl acetate extracts of solid fermentation from Xylaria nigripes. X. nigripes, a traditional Chinese medicinal fungus utilized for treating various ailments such as insomnia, trauma, and depression, has garnered attention due to its pharmacological potential.

Correction: Photochemical upcycling of polymers visible light-driven C-H bond activation.

Correction for 'Photochemical upcycling of polymers visible light-driven C-H bond activation' by Yi Wei , , 2025, https://doi.org/10.1039/D4CC05866F.

Late-Stage Functionalization of Guanine-Based Nucleosides, Nucleotides, and Oligonucleotide: Synthesis and Derivatization of Tricyclic Nucleoside Analogues.

We report here the synthesis of tricyclic nucleoside analogues via acid-catalyzed cyclization of guanine with 1,1,3,3-tetramethoxypropane. The method enables the use of hydroxyl-unprotected antiviral drugs (acyclovir, ganciclovir, and penciclovir), guanosines, oligonucleotide, and triazole-linked nucleoside dimers as substrates. Nucleoside trimer and tetramer were synthesized by derivatization reactions.

A quinoline colorimetric ionic liquid probe by electrostatic enhancement for visual detection of Fe in food.

Excessive or insufficient iron(Ⅲ) will pose burdens of human body, and its content is the key to control the function of iron-fortified food. In this regard, a functionalized quinoline ionic probe, benefiting from the electrostatic attraction, was designed for the colorimetric detection of Fe in food. This probe formed a 2: 1 complex with Fe, altering the UV-vis spectra and solution color.