Universal Bipolar Host Materials for Blue, Green, and Red Phosphorescent OLEDs with Excellent Efficiencies and Small-Efficiency Roll-Off.

Host materials are indispensable for the fabrication of organic light-emitting diodes (OLEDs) with phosphorescent emitters, but high-quality host materials that can efficiently and simultaneously function in blue, green, and red phosphorescent OLEDs (PHOLEDs) are much rare. In this work, four bipolar materials are developed using carbazole and 9,9-dimethyl-9,10-dihydroacridine as hole-transporting groups, pyridine as electron-transporting groups, and biphenyl and -methylbiphenyl as π-spacers. The crystal and electronic structures indicate that these materials have highly twisted conformations, which endow them with aggregation-induced emission features, intramolecular charge transfer processes, wide energy band gaps, and high triplet energies.

Self-Supported Hierarchical IrO@NiO Nanoflake Arrays as an Efficient and Durable Catalyst for Electrochemical Oxygen Evolution.

Although traditional IrO nanoparticles loaded on a carbon support (IrO@C) have been taken as a benchmark catalyst for the oxygen evolution reaction (OER), their catalytic efficiency, operation stability, and IrO utilization are far from satisfactory due to the inferior powdery structure and inevitable corrosion of both IrO and C under the oxidizing potentials. Here, a rational design of a self-supported hierarchical nanocomposite, composed of IrO@NiO nanoparticle-built porous nanoflake arrays vertically growing on nickel foam, is proposed, which is demonstrated as a versatile strategy to achieve improved OER activity, remarkable long-term stability, and significantly reduced loading of IrO (0.62 atom %).

Efficient visible light modulation based on electrically tunable all dielectric metasurfaces embedded in thin-layer nematic liquid crystals.

All-dielectric metasurfaces have attracted attention for highly efficient visible light manipulation. So far, however, they are mostly passive devices, while those allowing dynamic control remain a challenge. A highly efficient tuning mechanism is immersing the metasurface in a birefringent liquid crystal (LC), whose refractive index can be electrically controlled.

Chemoembolization with CalliSpheres drug-eluting beads loaded with irinotecan in the treatment of unresectable colorectal cancer liver metastases: preliminary results in 16 cases.

Background: To analyze the perioperative safety and effectiveness of chemoembolization with CalliSpheres drug-eluting beads (DEBs) loaded with irinotecan (DEBIRI) in the treatment of unresectable colorectal cancer liver metastases (CRCLM).

Methods: The clinical data of 16 colorectal cancer patients with postoperative liver metastases who were treated with chemoembolization using DEBIRI in our center from March 2017 to December 2018 were retrospectively analyzed. The treatment responses 3 and 6 months after the chemoembolization was evaluated with the modified Response Evaluation Criteria in Solid Tumors (mRECIST).

MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1.

Background: While microRNAs (miRNAs) are known to play a critical role in the progression of colorectal cancer, the role of miR-107 remains unknown. We evaluated its role and explored the underlying mechanism.

Materials & Methods: MTT, wound-healing, transwell migration and transwell invasion assays were performed to evaluate the role of miR-107 in SW629 cell proliferation, migration and invasion.

Epitaxial growth of a 100-square-centimetre single-crystal hexagonal boron nitride monolayer on copper.

The development of two-dimensional (2D) materials has opened up possibilities for their application in electronics, optoelectronics and photovoltaics, because they can provide devices with smaller size, higher speed and additional functionalities compared with conventional silicon-based devices. The ability to grow large, high-quality single crystals for 2D components-that is, conductors, semiconductors and insulators-is essential for the industrial application of 2D devices. Atom-layered hexagonal boron nitride (hBN), with its excellent stability, flat surface and large bandgap, has been reported to be the best 2D insulator.

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.

Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin complex 1 (mTORC1) and downregulation of Sirt1. We generated mice with DMP1-Cre-directed Tsc1 gene deletion ( Tsc1 CKO) to constitutively activate mTORC1 in osteocytes.

Light-sheet microscopy in the near-infrared II window.

Non-invasive deep-tissue three-dimensional optical imaging of live mammals with high spatiotemporal resolution is challenging owing to light scattering. We developed near-infrared II (1,000-1,700 nm) light-sheet microscopy with excitation and emission of up to approximately 1,320 nm and 1,700 nm, respectively, for optical sectioning at a penetration depth of approximately 750 μm through live tissues without invasive surgery and at a depth of approximately 2 mm in glycerol-cleared brain tissues. Near-infrared II light-sheet microscopy in normal and oblique configurations enabled in vivo imaging of live mice through intact tissue, revealing abnormal blood flow and T-cell motion in tumor microcirculation and mapping out programmed-death ligand 1 and programmed cell death protein 1 in tumors with cellular resolution.

A comprehensive clinical diagnostic score system for prediction of coronary artery spasm in patients with acute chest pain.

Background: Currently, there is no validated multivariate model to predict probability of coronary artery spasm (CAS) in patients with acute chest pain.

Methods: A total of 976 consecutive patients with acute chest pain were enrolled. Patients were divided into two groups based on the presence of significant CAS.

[Rh(L-alaninate)(1,5-Cyclooctadiene)] Catalyzed Helix-Sense-Selective Polymerizations of Achiral Phenylacetylenes.

The [Rh(L-alaninate)(cod)] (cod = 1,5-Cyclooctadiene) complex was synthesized and characterized. Asymmetric polymerizations of achiral phenylacetylene with two hydroxyl groups and a dodecyl group () were performed by using the rhodium complex as the catalyst to provide polymers with a higher molecular weight (>10⁵) than the polymers obtained using the [Rh(cod)Cl]₂ initiator systems. The resulting polymers showed circular dichroism (CD) signals at approximately 310 and 470 nm, indicating that they have a preferential one-handed helical structure.

Universal Imaging of Full Strain Tensor in 2D Crystals with Third-Harmonic Generation.

Quantitatively mapping and monitoring the strain distribution in 2D materials is essential for their physical understanding and function engineering. Optical characterization methods are always appealing due to unique noninvasion and high-throughput advantages. However, all currently available optical spectroscopic techniques have application limitation, e.

Sympathectomy versus conventional treatment for refractory coronary artery spasm.

Background: There is no clear consensus on the potential efficacy and indications for sympathectomy to prevent recurrence of vasospasm in patients with refractory coronary artery spasm (CAS).

Objective: To compare the clinical outcomes of sympathectomy with those of conventional treatment in patients with refractory CAS.

Patients And Methods: Patients with refractory CAS were randomly assigned to sympathectomy group (n = 37) or conventional treatment group (n = 42).

Photo-writing self-erasable phosphorescent images using poly(N-vinyl-2-pyrrolidone) as a photochemically deoxygenating matrix.

A passive photo-writing approach for optical data recording is described. Poly(N-vinyl-2-pyrrolidone) has been demonstrated as a photochemically deoxygenating polymeric matrix in which phosphorescent images from a molecular phosphor could be written by photo-activation and be competitively erased by diffusional oxygen quenching.

Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells.

Nuclear factor-kappa B (NF-κB) activation is critical for innate immune responses. However, cellular-intrinsic regulation of NF-κB activity during inflammatory diseases remains incompletely understood. Ubiquitin-like protein 4A (UBL4A, GdX) is a small adaptor protein involved in protein folding, biogenesis and transcription.

Spinon confinement and a sharp longitudinal mode in YbPtPb in magnetic fields.

The fundamental excitations in an antiferromagnetic chain of spins-1/2 are spinons, de-confined fractional quasiparticles that when combined in pairs, form a triplet excitation continuum. In an Ising-like spin chain the continuum is gapped and the ground state is Néel ordered. Here, we report high resolution neutron scattering experiments, which reveal how a magnetic field closes this gap and drives the spin chains in YbPtPb to a critical, disordered Luttinger-liquid state.

Synthesis, optimization and applications of ZnO/polymer nanocomposites.

Polymer composites have established an excellent position among the technologically essential materials because of their wide range of applications. An enormous research interest has been devoted to zinc oxide (ZnO) based polymer nanocomposites, due to their exceptional electrical, optical, thermal, mechanical, catalytic, and biomedical properties. This article provides a review of various polymer composites consisting of ZnO nanoparticles (NPs) as reinforcements, exhibiting excellent properties for applications such as the dielectric, sensing, piezoelectric, electromagnetic shielding, thermal conductivity and energy storage.

Efficient lung cancer-targeted drug delivery a nanoparticle/MSC system.

Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug.

Correction: Theoretical insights into intermolecular interactions during d organometallic self-aggregation.

Correction for 'Theoretical insights into intermolecular interactions during d8 organometallic self-aggregation' by Mo Xie et al., Dalton Trans., 2019, 48, 1275-1283.

Author Correction: Elastic pseudospin transport for integratable topological phononic circuits.

The original version of this Article contained errors in the second sentence in the legend of Fig. 1, which incorrectly read 'These two elastic insulators are identical in lattice constant a (3a), plate thickness (0.4a), and radius of perforated holes r (0.

Low-modulus biomedical Ti-30Nb-5Ta-3Zr additively manufactured by Selective Laser Melting and its biocompatibility.

Low Young's modulus titanium alloys, such as Ti-30Nb-5Ta-3Zr (TNTZ) of this study, were promising biocompatible implant materials. In this work, TNTZ samples with relative density of 96.8%-99.

One-pot facile simultaneous synthesis of conductive Ag-polyaniline composites using Keggin and Preyssler-type phosphotungstates.

Two heteropolytungstate structures, Keggin (HPWO) and Preyssler (H[NaPWO]), were used to synthesize conductive silver nanoparticle-polyaniline-heteropolytungstate (AgNPs-PAni-HPW) nanocomposites. During the oxidative polymerization of aniline, heteropolyblue was generated and served as the reducing agent to stabilize and distribute AgNPs within "PAni-Keggin" and "PAni-Preyssler" matrixes as well as on their surfaces. The prepared nanocomposites and AgNPs were characterized using UV-visible (UV-Vis) and Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), pore size distribution BET, scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

Origin of Ferroelectricity in Epitaxial Si-Doped HfO Films.

HfO-based unconventional ferroelectric materials were recently discovered and have attracted a great deal of attention in both academia and industry. The growth of epitaxial Si-doped HfO films has opened up a route to understand the mechanism of ferroelectricity. Here, we used pulsed laser deposition to grow epitaxial Si-doped HfO films in different orientations of N-type SrTiO substrates.

Exploring Future Food Provision Scenarios for China.

Developing sustainable food systems is essential, especially for emerging economies, where food systems are changing rapidly and affect the environment and natural resources. We explored possible future pathways for a sustainable food system in China, using multiple environmental indicators linked to eight of the Sustainable Development Goals (SDGs). Forecasts for 2030 in a business as usual scenario (BAU) indicate increases in animal food consumption as well as increased shortages of the land available and the water needed to produce the required food in China.

Theoretical insights into intermolecular interactions during d organometallic self-aggregation.

Metallophilicity was once considered as the major driver of aggregation in metal-organic complexes. However, the contributions of other intermolecular interactions cannot be neglected. We performed a theoretical study on the intermolecular interactions involved in the aggregation of a series of planar organoplatinum(ii) complexes with different substituents.