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South Korea; KAIST Center for Neuroscie... Publications | LitMetric

376,795 results match your criteria: "South Korea; KAIST Center for Neuroscience-inspired AI[Affiliation]"

Unraveling Serial Degradation Pathways of Supported Catalysts through Reliable Electrochemical Liquid-Cell TEM Analysis.

J Am Chem Soc

December 2024

Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.

Electrochemical liquid-cell transmission electron microscopy (e-LCTEM) offers great potential for investigating the structural dynamics of nanomaterials during electrochemical reactions. However, challenges arise from the difficulty in achieving the optimal electrolyte thickness, leading to inconsistent electrochemical responses and limited spatial resolution. In this study, we present advanced e-LCTEM techniques tailored for tracking Pt/C degradation under electrochemical polarization at short intervals with high spatial resolution.

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The electrochemical nitrate reduction reaction (NORR) involves multiple hydrogenation and deoxygenation steps, which compete with the hydrogen evolution reaction (HER). Therefore, NORR driven in acidic media is challenging in spite of advantageous fast hydrogen transfers in its elementary steps. The findings presented in this article first demonstrate that the NORR is significantly activated even in acidic lithium nitrate solutions at LiNO concentrations exceeding 6 m on a Pt electrode (the highly effective catalyst for HER) by the formation of a "hydronium-in-salt" electrolyte (HISE), a new type of aqueous high concentration salt electrolyte.

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Background: Studies investigating constitutional alignment across various grades of osteoarthritis (OA) are limited. This study explored the distribution of Coronal Plane Alignment of the Knee (CPAK) types and associated radiographic parameters with increasing OA severity.

Methods: In this retrospective cross-sectional study, 17,365 knees were analyzed using deep learning software for radiographic measurements.

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Background: Mammographic breast density has been suggested to play a role as a mediator between the risk factors for breast cancer (BC) and BC risk. We investigated the extent to which never breastfeeding is a risk factor for BC and how this risk is further mediated by increased mammographic breast density.

Methods: This retrospective cohort study included 4 136 723 women aged ≥40 years who underwent mammographic screening between 2009 and 2010 and were followed up until 31 December 2020.

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Based on the analysis of the structures of robots and electronics developed so far, it should be noted that a majority of them need a reservoir for electrical energy storage. Unfortunately, most off-the-shelf devices commercially available nowadays are based on rigid parts that heavily limit the possibilities of incorporating such products into soft robots and wearable electronics. To address these issues, a new type of flexible structure for electrical energy storage, which consists of small battery cells connected by liquid metal paths, was proposed.

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Optimal Sensor Placement for Motion Tracking of Soft Wearables Using Bayesian Sampling.

Soft Robot

December 2024

Department of Mechanical Engineering, Institute of Advanced Machines and Design, Institute of Engineering Research, Seoul National University, Seoul, Republic of Korea.

Soft sensors integrated or attached to robots or human bodies enable rapid and accurate estimation of the physical states of the target systems, including position, orientation, and force. While the use of a number of sensors enhances precision and reliability in estimation, it may constrain the movement of the target system or make the entire system complex and bulky. This article proposes a rapid, efficient framework for determining where to place the sensors on the system given the limited number of available sensors.

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Background: The integration of connected medical devices (MDs) into health care brings benefits but also introduces new, often challenging-to-assess risks related to cybersecurity, which have the potential to harm patients. Current regulations in the European Union and the United States mandate the consideration of these risks in the benefit-risk analysis (BRA) required for MD approval. This important step in the approval process weighs all the defined benefits of a device with its anticipated risks to ensure that the product provides a positive argument for use.

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Purpose: This study investigated the occurrence of subsequent malignancies (SM) in adult patients with severe aplastic anemia (SAA) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) to address the lack of large-scale, long-term data on this complication.

Methods: A retrospective cohort analysis of 376 adult patients with SAA who underwent allo-HSCT between 2002 and 2021 at a single center was conducted. The incidence, risk factors, and survival impact of SM were also examined.

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Human pluripotent stem cells (hPSCs) have at least three distinct states: naïve pluripotency that represents the cellular states of the pre-implantation epiblast cells, primed pluripotency that represents the cellular states of the post-implantation epiblast cells, and formative pluripotency that represents a developmental continuum between naïve and primed pluripotency. Various cell surface markers have been used to define and analyze primed and naïve hPSCs within heterogeneous populations. However, not much is known about common cell surface markers for the different pluripotent states of hPSCs.

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Strategies for integrating ChatGPT and generative AI into clinical studies.

Blood Res

December 2024

Department of Surgery, Division of HBP Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-Gu, Seoul, 03080, Republic of Korea.

Large language models, specifically ChatGPT, are revolutionizing clinical research by improving content creation and providing specific useful features. These technologies can transform clinical research, including data collection, analysis, interpretation, and results sharing. However, integrating these technologies into the academic writing workflow poses significant challenges.

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Among the numerous residential appliances, window or split air conditioners are the most prevalent. The hydrochlorofluorocarbon and hydrofluorocarbon refrigerants used in those systems are causing a serious threat to the environment. In this study, R290-hydrofluoroolefin (HFO) mixtures are proposed as replacements for high-GWP substances (R410A and R22) in window air conditioning (WAC) units.

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A Gram-stain-negative, aerobic, non-spore-forming, non-motile, coccus-shaped, and red-pigmented bacterial strain designated as CJ14 was isolated from lettuce cultivation soil in Yong-In, South Korea. Strain CJ14 grew optimally on Luria-Bertani agar at 37 ℃ and pH 7.0 in the absence of NaCl.

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Objectives: We assessed the reliability and validity of the Korean version of the Pain-related Beliefs and Attitudes about Sleep (PBAS) scale among patients with chronic pain. Furthermore, we investigated whether pan-related dysfunctional beliefs about sleep mediate the relationship between sleep severity and pain.

Methods: Overall, 100 participants with chronic pain were recruited using an anonymous online survey.

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Excessive reactive oxygen species (ROS) generated by ultraviolet (UV) irradiation significantly contribute to photoaging by increasing the level of matrix metalloproteinases (MMPs), accelerating collagen degradation. Commercial dermal fillers offer temporary wrinkle reduction via volume enhancement. In this study, we propose tilapia-derived collagen hydrogels embedded with ceria nanoparticles (Ce@Col gels) as long-lasting dermal fillers for UVB-induced photoaging.

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Purpose: This study aimed to quantitatively analyze temporomandibular joint (TMJ) space volume changes before and after bilateral sagittal split ramus osteotomy (BSSRO) with intended manual condyle positioning in patients with severe facial asymmetry.

Methods: A retrospective study was conducted, including 20 patients with facial asymmetry (menton deviation >8 mm) who underwent BSSRO with intended manual condyle positioning at a single institution. Cone beam computed tomography (CBCT) images were obtained preoperatively (T0), 2 days postoperatively (T1), and 6 months postoperatively (T2).

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Effect of PEGylation on the Adsorption and Binding Strength of Plasma Proteins to Nanoparticle Surfaces.

Mol Pharm

December 2024

Department of Chemical Engineering, Dankook University, Yongin-si 16890, South Korea.

The adsorption of plasma proteins (human serum albumin, immunoglobulin γ-1, apolipoproteins A-I and E-III) onto polystyrene surfaces grafted with polyethylene glycol (PEG) at different grafting densities is simulated using an all-atom PEG model validated by comparing the conformations of isolated PEG chains with previous simulation and theoretical values. At high PEG density, the grafted PEG chains extend like brushes, while at low density, they significantly adsorb to the surface due to electrostatic attraction between polystyrene amines and PEG oxygens, forming a PEG layer much thinner than its Flory radius. Free energy calculations show that PEGylation can either increase or decrease the binding strength between proteins and surfaces, to an extent dependent on PEG density and specific proteins involved, in agreement with experiments.

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Growth of the metal-organic framework ZIF-67 on cellulosic substrates for triboelectric nanogenerators.

Nanoscale

December 2024

Nanomaterials and Systems Laboratory, Major of Mechatronics Engineering, Faculty of Applied Energy Systems, Jeju National University, Jeju-si, Republic of Korea.

Metal-organic frameworks (MOFs) are porous crystalline materials with a metal ion coordinated to a ligand molecule. Recently, MOFs are being explored extensively for energy harvesting triboelectrification. However, the majority of MOFs are brittle and hard to grow, thus leading to poor device stability and flexibility.

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Life course social mobility and cognitive function among middle-aged and older adults in India: Exploring heterogeneity by gender.

Soc Sci Med

December 2024

Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Republic of Korea; Division of Health Policy and Management, College of Health Science, Korea University, Seoul, Republic of Korea. Electronic address:

This study investigates the link between life course social mobility and cognitive function among middle-aged and older adults in India, specifically emphasizing whether upward and downward mobility exerts symmetric associations and potential gender heterogeneity within these associations. Leveraging data from the Longitudinal Aging Study in India 2017-2018, encompassing 64,710 individuals aged 45 years or above, we classified social mobility as 'consistently high,' 'upward mobility,' 'downward mobility,' and 'consistently low,' based on socioeconomic position during childhood and late adulthood. Multivariable regression and gender-interaction analyses were employed to assess associations.

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Risk of extrahepatic malignancies in patients with autoimmune hepatitis: a nationwide cohort study.

Am J Gastroenterol

December 2024

Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Introduction: Nationwide, population-based data on the risk of extrahepatic malignancy in patients with autoimmune hepatitis (AIH) in Asian countries are scarce. This study aimed to examine the risk of developing extrahepatic malignancies in a nationwide cohort of patients with AIH.

Methods: Using claims data from the Korean National Health Insurance Service database, patients diagnosed with AIH between 2007 and 2019 (n=7,382) were matched in a 1:8 ratio with an age- and sex-matched control population (n=58,320).

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Ionic Diode-Based Drug Delivery System.

Adv Mater

December 2024

Department of Material Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

Drug delivery systems hold promise for delivering cytotoxic drugs by controlling the timing and location of the drug release. However, conventional delivery mechanisms often fall short of achieving spatiotemporally controlled yet sustained release, which is crucial for ensuring drug efficacy and minimizing impact on surrounding tissues. Here, an ionic diode-based drug delivery system is reported that is controlled by an electric potential and capable of releasing drugs at scales ranging from nanogram to microgram.

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Escitalopram is commonly prescribed for depressive and anxiety disorders in elderly patients, who often show variable drug responses and face higher risks of side effects due to age-related changes in organ function. The CYP2C19 polymorphism may further affect escitalopram pharmacokinetics in elderly patients, complicating dose optimization for this group. Previous pharmacogenetic studies examining the impact of CYP2C19 phenotype on escitalopram treatment outcomes have primarily focused on younger adults, leaving a gap in understanding its effects on the elderly.

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An unprecedented amount of SARS-CoV-2 data has been accumulated compared with previous infectious diseases, enabling insights into its evolutionary process and more thorough analyses. This study investigates SARS-CoV-2 features as it evolved to evaluate its infectivity. We examined viral sequences and identified the polarity of amino acids in the receptor binding motif (RBM) region.

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Hierarchical binder-free NiCoO@CuS composite electrodes have been successfully fabricated on a nickel foam surface using a facile hydrothermal method and directly used as a battery-type electrode material for supercapacitor applications. The surface morphological studies reveal that the composite electrode exhibited porous NiCoO nanograss-like structures with CuS nanostructures. The surface area of the composite is significantly enhanced (91.

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This study aimed to determine optimal washing and drying methods for maintaining the functionality of silver-coated conductive knitted fabrics, commonly used in wearable smart products. By investigating changes in the physical, chemical, and electrical properties of these fabrics under various care conditions, we sought to provide recommendations for their proper maintenance. Results showed that mechanical friction during washing, combined with the chemical effect of detergent and the effects of machine drying, led to peeling and oxidation of the silver layer, resulting in changes to the fabric's appearance, color and increased surface resistance.

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Photoelectrochemical water splitting is a promising technology for converting solar energy into chemical energy. For this system to be practically viable, the materials and processes employed for photoelectrode fabrication should be cost-effective and scalable. Herein, we report the large-scale fabrication of nickel oxide-coated n-type silicon (n-Si) photoanodes chemical bath deposition for efficient photoelectrochemical water oxidation.

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