Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats.

In April 2024, ten cats died in a rural South Dakota (SD) residence, showing respiratory and neurological symptoms. Necropsy and laboratory testing of two cats confirmed H5N1 clade 2.3.

Revision of Vitruvius (Hemiptera: Heteroptera: Pentatomidae) with the description of a new species from Cambodia and Thailand.

The monotypic Oriental genus Vitruvius Distant, 1901 (Hemiptera: Heteroptera: Pentatomidae: Pentatominae), having an intricate and confusing taxonomic history, is revised. A new species, Vitruvius dobby Roca-Cusachs, Rider & Kment new species, is described from Cambodia and Thailand. Notes on the hypothesized classification of the genus based on both biology and morphology are presented, but its systematic placement is left unresolved.

Desert Bugs (Hemiptera: Heteroptera: Thaumastellidae): New records and review of the distribution and habitat of this relict group.

The known distribution and habitat information of the three described species of the genus Thaumastella Horváth, 1896 (Hemiptera: Heteroptera: Pentatomomorpha: Pentatomoidea: Thaumastellidae) are reviewed. In addition a fourth, undescribed species is reported from South Africa (Western Cape). Thaumastella aradoides Horváth, 1896, is recorded for the first time from Egypt, Oman, Saudi Arabia, United Arab Emirates, and the states of Khartoum and Sennar in Sudan.

Progeny array analysis to estimate outcrossing rates, inbreeding coefficients, and inbreeding depression among native, naturalized, and invasive populations of (Phrymaceae).

The mating system of non-native plant populations plays a role in determining the colonizing success following introduction into locations outside of the native distribution. For plant species capable of mixed-mating, both selfing and outcrossing can be advantageous and promote the establishment, persistence, and spread of newly arrived populations. To investigate how mating systems may contribute to the invasion process we estimated mating system parameters in perennial populations of the model plant species, from its native range (West coast USA), non-native populations that are established but have not become invasive (East coast USA, >50 years), and populations in invasive regions (UK >200 years).

University student perspectives on antimicrobial peptide use in farm animals.

Growing awareness of antimicrobial resistance (AMR) in livestock production has led to calls for the development of alternatives such as antimicrobial peptides (AMPs) that are also able to combat infectious diseases in farm animals. A critical step in the development of AMPs is to understand people's perspectives towards this technology to avoid misalignment with societal expectations. The aim of this study was to investigate university student perspectives of AMP applications in farm animals as alternatives to antibiotic use.

Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.

Objective: To investigate the association between plasma omega-3 levels and incident heart failure (HF) and to examine their relationship with total and cardiovascular (CV) mortality among patients with preexisting HF.

Patients And Methods: The UK Biobank is an ongoing prospective cohort study of individuals recruited in the United Kingdom between April 1, 2007, and December 31. 2010.

Effects of polyphenols on gut microbiota and inflammatory markers in individuals with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials.

Polyphenols are potent antioxidants with anti-microbial, anti-inflammatory, and prebiotic effects. However, no meta-analysis of human studies has confirmed these properties in individuals with overweight or obesity and elucidated the underlying mechanisms. Hence, this work aimed to investigate the impact of polyphenols on gut microbiota composition, short-chain fatty acids (SCFAs), and inflammatory markers in individuals with overweight or obesity from randomized controlled trials.

Cervical Cancer 2010-2019: An Upper Midwest Catchment of 40,000 Square Miles.

Objectives: American Indian (AI) women have a higher incidence and mortality from cervical cancer than non-Hispanic White (NHW) women in the US. This article's purpose is to detail the clinical events in the cervical cancer prevention continuum among the AI and White women with cervical cancer on the US frontier.

Materials And Methods: A cancer center with a nearly 40,000 square-mile catchment area maintained a detailed cancer registry connected to the clinic records of all cervical cancer patients between 2010-2019.

Rumen-protected methionine supplementation improves lactation performance and alleviates inflammation during a subclinical mastitis challenge in lactating dairy cows.

This study aimed to evaluate the effects of rumen-protected Met on lactation performance, inflammation, and immune response, and liver glutathione of lactating dairy cows during a subclinical mastitis challenge (SMC). Thirty-two Holstein cows (145 ± 51 DIM) were enrolled in a randomized complete block design. At -21 d relative to the SMC, cows were assigned to dietary treatments, and data were collected before and during the SMC.

Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword.

Objective: Studies regarding effects of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on risk of atrial fibrillation (AF) have reported discordant results. The aim of this review is to clarify effects of marine omega-3 intake on risk of AF.

Patients And Methods: A PubMed search was performed using terms: atrial fibrillation, omega-3, EPA, DHA, vagal tone.

Ezrin drives adaptation of monocytes to the inflamed lung microenvironment.

Ezrin, an actin-binding protein, orchestrates the organization of the cortical cytoskeleton and plasma membrane during cell migration, adhesion, and proliferation. Its role in monocytes/macrophages (MΦs) is less understood. Here, we used a monocyte/MΦ-specific ezrin knock-out mouse model to investigate the contribution of ezrin to monocyte recruitment and adaptation to the lung extracellular matrix (ECM) in response to lipopolysaccharide (LPS).

HeteroKGRep: Heterogeneous Knowledge Graph based Drug Repositioning.

The process of developing new drugs is both time-consuming and costly, often taking over a decade and billions of dollars to obtain regulatory approval. Additionally, the complexity of patent protection for novel compounds presents challenges for pharmaceutical innovation. Drug repositioning offers an alternative strategy to uncover new therapeutic uses for existing medicines.

It Can No Longer Be Optional-Medical Billing in the PharmD Curriculum.

Pharmacists across the United States are rapidly gaining the ability to bill the medical benefit, increasing their ability to optimally and sustainably contribute to patient care. Medical billing is the process by which a provider submits a claim for reimbursement to the medical insurance benefit based on services provided to a patient. As pharmacists lean into new and expanding opportunities related to medical billing, pharmacy educators must also prepare graduates who can explain the importance of and execute skills related to medical billing.

Fostering the international interoperability of clinical research networks to tackle undiagnosed and under-researched rare diseases.

Clinical research is an essential component to advance diagnosis and therapeutic development. In 2022, the International Rare Diseases Research Consortium (IRDiRC) and the European Joint Programme on Rare Diseases (EJP RD) brought together key stakeholders from across the globe to discuss common themes in clinical research networks (CRNs) for rare diseases. Various topics were raised during discussions including current state of CRNs, the need for new CRNs, multi-stakeholder perspectives on value of CRNs, and ways to collaborate on a global scale.

The impact of hemoglobin concentration on farrowing duration in sows.

Concerns have been raised about the prevalence of anemia in sows, yet our understanding of its consequences, particularly its impact on the farrowing process, remains limited. This study investigated the relationship between hemoglobin concentration () and farrowing duration in sows. A total of 101 sows ( = 16 parity 0, 15 parity 1, 24 parity 2, and 46 parity 3 sows) were monitored for blood HbC (Hemocue Hb 201 device) from the ear vein before farrowing (day 112 of gestation) and between 40 to 48 h after farrowing (day 2).