Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression.

Long non-coding RNAs (lncRNAs) are key regulators of cellular processes that underpin cancer development and progression. DRAIC is a migration inhibitor that has been linked with lung adenocarcinoma progression; however, its mechanisms remain to be studied. Several bioinformatics tools were used to explore the role of DRAIC in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).

Smart Physiotherapy: Advancing Arm-Based Exercise Classification with PoseNet and Ensemble Models.

Telephysiotherapy has emerged as a vital solution for delivering remote healthcare, particularly in response to global challenges such as the COVID-19 pandemic. This study seeks to enhance telephysiotherapy by developing a system capable of accurately classifying physiotherapeutic exercises using PoseNet, a state-of-the-art pose estimation model. A dataset was collected from 49 participants (35 males, 14 females) performing seven distinct exercises, with twelve anatomical landmarks then extracted using the Google MediaPipe library.

Determining unmet need: clinical relevance of suspected neurodivergence in first-episode psychosis.

Aims And Method: We explored the prevalence of autism and attention-deficit hyperactivity disorder in first-episode psychosis. Through service evaluation involving 509 individuals, detailed analyses were conducted on neurodevelopmental traits and patterns of service utilisation.

Results: Prevalence of neurodivergence in first-episode psychosis was 37.

When (and why) absolute decision attribute values influence human preferences.

Relative rank models of risky decision-making suggest that human preferences are informed by sampled (and not absolute) values and their relative ranks. According to this proposal, an attribute's absolute value (e.g.

Loss of Control Eating in Adults With Impulsive and/or Inattentive Tendencies.

Objective: Previous research has tended to consider impulsive, inattentive, and loss of control eating (LOC) tendencies as symptoms of greater pathologies in treatment-seeking samples. However, inattentive and impulsive tendencies and LOC often co-occur. Although LOC is an important diagnostic component of disordered eating (ED), it has recently been argued to be a dysregulated eating behavior in its own right.

Workforce research priorities for resilience to future health shocks-and the workforce crisis.

More and better research is needed now to develop an evidence base that informs policy to maximise workforce effectiveness and wellbeing to respond to both the next health shock and the ongoing shock of the workforce crisis, write

WingAnalogy: a computer vision-based tool for automated insect wing asymmetry and morphometry analysis.

WingAnalogy is a computer tool for automated insect wing morphology and asymmetry analysis. It facilitates project management, enabling users to import pairs of wing images obtained from individual insects, such as left and right, fore- and hindwings. WingAnalogy employs image processing and computer vision to segment wing structures and extract cell boundaries, and junctions.

Patient-specific pulmonary venous flow characterization and its impact on left atrial appendage thrombosis in atrial fibrillation patients.

Background: Cardioembolic strokes are commonly occurred in non-valvular atrial fibrillation (AF) patients, with over 90% of cases originating from clot in left atrial appendage (LAA), which is believed to be greatly related with hemodynamic characters. Numerical simulation is widely accepted in the hemodynamic analysis, and patient-specific boundaries are required for realistic numerical simulations.

Method: This paper firstly proposed a method that maps personalized pulmonary venous flow (PVF) by utilizing the volume changes of the left atrium (LA) over the cardiac cycle.

Weak and interfered self-control fails to block problematic mobile phone use: The role of craving and desire thinking.

Problematic mobile phone use (PMPU) has become a worldwide phenomenon with negative impacts on adolescents' daily lives. While self-control has been shown to be related to PMPU, little is known about the underlying mechanisms of this association. Based on the Interaction of Person-Affect-Cognition-Execution model and the strength model of self-control, the current study aims to examine the association between self-control and PMPU, to identify the indirect role of craving, and to determine whether and how the two components of desire thinking exert differential moderating effects.

Why are healthcare professionals leaving NHS roles? A secondary analysis of routinely collected data.

Background: Much policy attention focuses on increasing the supply of workers in the English NHS but there has been less attention paid to the rise in leavers. This paper seeks to explore how existing data sets can illuminate the decision-making of leavers and inform actions that could mitigate this.

Method: Secondary analysis of routinely collected data from 79 workforce projects in the UK (n = 46 339 participants) over a 4-year (2019-2023) period was undertaken.

The effect of products containing high concentration corrosive substances on the recovery of fingermarks from non-porous surfaces.

Fingermark recovery plays a crucial role in investigating corrosive substance attacks, which are becoming increasingly common. Building upon previous research, this study aimed to identify effective visualization processes for recovering fingermarks from diverse substrates exposed to wide range of commercially available corrosive materials. The study investigated glass, PVC and HDPE substrates with fingermarks deposited 1 day and 2 weeks before exposure to the corrosive substance, and used commercially available substances at concentrations higher than any previous study.

Easy to gain but hard to lose: the evolution of the knee sesamoid bones in Primates-a systematic review and phylogenetic meta-analysis.

Sesamoids are variably present skeletal elements found in tendons and ligaments near joints. Variability in sesamoid size, location and presence/absence is hypothesized to enable skeletal innovation, yet sesamoids are often ignored. Three knee sesamoids-the cyamella, medial fabella and lateral fabella-are present in primates, but we know little about how they evolved, if they are skeletal innovations, or why they are largely missing from Hominoidea.

The Roles of Rule Type and Word Term in the Deductive Reasoning of Adults with and without Dyslexia.

Despite its importance to everyday functioning, reasoning is underexplored in developmental dyslexia. The current study investigated verbal deductive reasoning on the Wason selection task, not previously used in dyslexia research despite its well-established pedigree. Reasoning rule was manipulated, with the conditional rules varying in the logical values presented.

Paediatric oncology physiotherapy in Africa: International Society of Paediatric Oncology (SIOP) Global Mapping Programme.

Childhood cancer treatment in Africa has a dramatically increasing patient population resulting in greater rehabilitation needs. The International Society of Paediatric Oncology (SIOP) mapped childhood cancer services in Africa including access to physiotherapy. Irrespective of income classification, just over two-thirds of countries in Africa reported having access to physiotherapy services in paediatric oncology sites.

Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging.

Introduction: We propose a novel approach for the non-invasive quantification of dynamic PET imaging data, focusing on the arterial input function (AIF) without the need for invasive arterial cannulation.

Methods: Our method utilizes a combination of three-dimensional depth-wise separable convolutional layers and a physically informed deep neural network to incorporatea priori knowledge about the AIF's functional form and shape, enabling precise predictions of the concentrations of [C]PBR28 in whole blood and the free tracer in metabolite-corrected plasma.

Results: We found a robust linear correlation between our model's predicted AIF curves and those obtained through traditional, invasive measurements.

Diffusion of innovation, pre-registration/licence student nurses' use of social media: A reflexive thematic analysis.

Aim: To identify and report the use of social media among pre-registration (pre-licence) student nurses.

Methods: A social survey was conducted in 2019 to explore student nurses' views of social media usage. Diffusion of innovation theory and social identity theory were used as the theoretical framework.