221,655 results match your criteria: "South Australia; and The South Australian Health and Medical Research Institute[Affiliation]"
Head Neck
January 2025
University of New South Wales, Sydney, New South Wales, Australia.
Objectives: Reconstruction of total pharyngolaryngectomy defects may restore pharyngeal function and enable tracheoesophageal speech after resection of locoregionally advanced malignancy. Little remains known about variations in the practices and preferences of surgeons across differing global regions.
Methods: A survey was sent to reconstructive head and neck surgeons across three continents with responses analyzed to evaluate trends.
Aust N Z J Psychiatry
January 2025
Queensland Alliance for Environmental Health Sciences, The University of Queensland, Brisbane, QLD, Australia.
J Adv Nurs
January 2025
SPHERE, NHMRC Centre of Research Excellence, Department of General Practice, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Aim: To assess the acceptability and perceived feasibility of integrating a co-designed nurse-led model of contraception and medication abortion care within rural and regional general practices.
Design: Qualitative exploratory design utilising Sidani and Braden's indicators of acceptability and feasibility.
Methods: We conducted semi-structured interviews with 12 practice nurses, 8 general practitioners and 3 practice managers who currently or previously worked in rural, regional or remote general practice.
J Adv Nurs
January 2025
President Office, Tung Wah College, Hong Kong SAR, People's Republic of China.
Aims: To synthesise evidence on decision regret about treatment amongst women with early breast cancer, including (1) the type of treatment related to decision regret, (2) the level of decision regret, and (3) factors associated with decision regret.
Design: Integrative review.
Methods: Studies published between January 2000 and December 2023 were searched from five online databases to provide up-to-date evidence.
Chron Respir Dis
January 2025
The Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Individuals with Preserved Ratio Impaired Spirometry (PRISm), defined as FEV/FVC ≥0.7 and FEV1 <80% predicted, are at higher risk of developing COPD. However, data for Australian adults are limited.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
School of Nursing & Midwifery, University of Newcastle, University Drive, Callaghan, New South Wales, Australia.
Aim: To systematically explore research on nurses' clinical decision-making and factors influencing pressure injury prevention in hospitalised patients.
Design: Scoping review.
Data Sources: Medline full text, Cumulative Index to Nursing and Allied Health Literature Plus with full text, and Scopus.
Introduction: Job satisfaction and intention to leave have been consistently linked to the working environment. However, there are few studies of interventions for improving the environment or staff outcomes.
Aim: To determine the impact of implementing a framework for safe nurse staffing on the environment and staff outcomes.
ANZ J Surg
January 2025
Orthopaedic Surgery, University of Adelaide, Adelaide, South Australia, Australia.
Nucleic Acids Res
January 2025
Bioinformatics Division, WEHI, Parkville, VIC 3052, Australia.
edgeR is an R/Bioconductor software package for differential analyses of sequencing data in the form of read counts for genes or genomic features. Over the past 15 years, edgeR has been a popular choice for statistical analysis of data from sequencing technologies such as RNA-seq or ChIP-seq. edgeR pioneered the use of the negative binomial distribution to model read count data with replicates and the use of generalized linear models to analyze complex experimental designs.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
January 2025
Department of Cancer Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Background: Despite promising preclinical studies, the application of DNA methyltransferase inhibitors in treating patients with solid cancers has thus far produced only modest outcomes. The presence of intratumoral heterogeneity in response to DNA methyltransferase inhibitors could significantly influence clinical efficacy, yet our understanding of the single-cell response to these drugs in solid tumors remains very limited.
Methods: In this study, we used cancer/testis antigen genes as a model for methylation-dependent gene expression to examine the activity of DNA methyltransferase inhibitors and their potential synergistic effect with histone deacetylase inhibitors at the single-cancer cell level.
Int J Equity Health
January 2025
Department of Public Health, Auckland University of Technology, Auckland, New Zealand.
Indigenous communities worldwide continue to disproportionately bear the burden during pandemics due to ongoing health inequities and systemic exclusion from pandemic decision-making processes. As the global community prepares for the next pandemic, it is critical to prioritise Indigenous leadership and governance within public health responses. This commentary highlights successful models of Indigenous-led pandemic responses during COVID-19 in Canada and Australia.
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
John Richards Centre for Rural Ageing Research, La Trobe Rural Health School, College of Science, Health and Engineering, La Trobe University, Edwards Road, Flora Hill, VIC 3550, Victoria, Australia.
Background: Evidence is limited on the factors influencing successful stroke rehabilitation in regional contexts. Additionally, the relationship between rehabilitation costs following acute stroke, based on Australian National Subacute and Non-Acute Patient (AN-SNAP) casemix classification, and rehabilitation success remains unclear.
Objective: This retrospective cohort study investigated the factors contributing to improved functional outcomes following stroke rehabilitation in an Australian regional hospital, also evaluating the respective average daily and total payments.
BMC Genomics
January 2025
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Background: Few studies have explored the association between DNA methylation and physical activity. The aim of this study was to evaluate the association of objectively measured hours of sedentary behavior (SB) and moderate physical activity (MPA) with DNA methylation. We further aimed to explore the association between SB or MPA related CpG sites and cardiometabolic traits, gene expression, and genetic variation.
View Article and Find Full Text PDFNPJ Antimicrob Resist
May 2024
Ausvet Europe, Lyon, France.
Antimicrobial stewardship (AMS) is a commonly advocated approach to address antimicrobial resistance. However, AMS is often defined in different ways depending on where it is applied, such that a range of definitions is now in use. These definitions may be functional and well-structured for a given context but are often ill-adapted for collaborative work, creating difficulties for intersectoral communication on AMS and complicating the design, implementation, and evaluation of AMS interventions from a One Health perspective.
View Article and Find Full Text PDFSci Data
January 2025
Centre for Ecosystem Science, School of Biological, Earth, and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Antarctica, Earth's least understood and most remote continent, is threatened by human disturbances and climate-related changes, underscoring the imperative for biodiversity inventories to inform conservation. Antarctic ecosystems support unique species and genetic diversity, deliver essential ecosystem services and contribute to planetary stability. We present Antarctica's first comprehensive ecosystem classification and map of ice-free lands, which host most of the continent's biodiversity.
View Article and Find Full Text PDFNPJ Antimicrob Resist
November 2024
Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Nature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFNature
January 2025
CancerResearch@UCC, University College Cork, Cork, Ireland.
The assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment. Here we present an outlook on research assessment for career progression with specific focus on promotion to full professorship, based on 314 policies from 190 academic institutions and 218 policies from 58 government agencies, covering 32 countries in the Global North and 89 countries in the Global South.
View Article and Find Full Text PDFSci Rep
January 2025
School of BioSciences, Centre of Excellence for Biosecurity Risk Analysis, University of Melbourne, Melbourne, 3010, Australia.
Climate change has direct impacts on current and future agricultural productivity. Statistical meta-analysis models can be used to generate expectations of crop yield responses to climatic factors by pooling data from controlled experiments. However, methodological challenges in performing these meta-analyses, together with combined uncertainty from various sources, make it difficult to validate model results.
View Article and Find Full Text PDFBehav Res Methods
January 2025
School of Psychology, University of New South Wales, Sydney, Australia.
With recent technical advances, many cognitive and sensory tasks have been adapted for smartphone testing. This study aimed to assess the criterion validity of a subset of self-administered, open-source app-based cognitive and sensory tasks by comparing test performance to lab-based alternatives. An in-person baseline was completed by 43 participants (aged 21 to 82) from the larger Labs without Walls project (Brady et al.
View Article and Find Full Text PDFMol Psychiatry
January 2025
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with their connections (edges) indicating the likelihood of one feature preceding the other. In SMD, node centrality could reveal insights into important prodromal features and potential intervention targets.
View Article and Find Full Text PDFIntroduction: Early pregnancy care involves the screening and identification of women with risk factors for adverse pregnancy outcomes, including stillbirth or preterm birth, to tailor pregnancy care and interventions accordingly. Most stillbirths and approximately two-thirds of preterm births, however, occur in the absence of evident risk factors. The majority of stillbirths occur in the preterm period, yet there are few interventions targeting this period, and progress to reduce stillbirth rates remains slow.
View Article and Find Full Text PDFeNeuro
January 2025
Research School of Psychology, Australian National University, 0200, Australia.
Inner speech refers to the silent production of language in one's mind. As a purely mental action without obvious physical manifestations, inner speech has been notoriously difficult to quantify. Inner speech is thought to be closely related to overt speech.
View Article and Find Full Text PDFThorac Cancer
January 2025
Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Background: Multiple studies have demonstrated the intracranial efficacy of immune checkpoint inhibitors (ICI) +/- chemotherapy. The efficacy of chemoimmunotherapy compared to ICI alone in patients with metastatic NSCLC and brain metastases (BM) remains unknown.
Methods: A systematic review and network meta-analysis were performed to evaluate ICI efficacy and the influence of additional chemotherapy on survival outcomes in treatment-naïve metastatic NSCLC with BM.
Brain
January 2025
Department of Neurology, University of South Carolina, Columbia, SC 29203, USA.
Despite decades of advancements in diagnostic MRI, 30-50% of temporal lobe epilepsy (TLE) patients remain categorized as "non-lesional" (i.e., MRI negative or MRI-) based on visual assessment by human experts.
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