2,731 results match your criteria: "South American Blastomycosis"
Multiple Tolerization Subtractive Immunization in the Obtention of Specific Monoclonal Antibodies Against .
Monoclon Antib Immunodiagn Immunother
December 2024
School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil.
Paracoccidioidomycosis (PCM) is a chronic endemic mycosis in Latin America, predominantly caused by (Pb18) and (Pl01). Diagnosing PCM is challenging due to species-specific antigenic differences, therefore new biomarkers for accurate and rapid detection are needed. This study explores multiple tolerization subtractive immunization (MTSI) to generate monoclonal antibodies against rare or weakly expressed epitopes of Pb18 and Pl01, potentially improving PCM diagnosis.
View Article and Find Full Text PDFParacoccidioidomycosis presenting as a cecal lesion mimicking cholangiocarcinoma: a case report of unusual intestinal manifestation.
Rev Inst Med Trop Sao Paulo
November 2024
Universidade Federal Fluminense, Faculdade de Medicina, Niterói, Rio de Janeiro, Brazil.
Paracoccidioidomycosis, the most important systemic mycosis in Latin America, is closely linked to rural activities. In Brazil, it is an endemic disease, with an estimated 4,000 to 6,000 annual cases, accounting for over 80% of the global diagnoses. We present an intriguing case of this disease with an intestinal manifestation in a 71-year-old woman.
View Article and Find Full Text PDFComparison between PCR-RFLP and sequencing techniques in the analysis of Paracoccidioides spp. biodiversity: limitations and insights into species and variant differentiation.
Mycopathologia
November 2024
Laboratório de Investigação Médica em Micologia (LIM53), Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Éneas de Carvalho Aguiar n470, Cerqueira Cézar, São Paulo, SP, 05403000, Brazil.
Background: The study of Paracoccidioides spp. faces significant challenges due to limitations inherent in the molecular biology techniques employed. Recently, new species were described whose geographical and genetic distributions were investigated.
View Article and Find Full Text PDFCase Report: Hypercalcemia and Acute Kidney Injury Associated with Disseminated Paracoccidioidomycosis.
Am J Trop Med Hyg
October 2024
Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Paracoccidioidomycosis is an acute to chronic systemic mycosis caused by the fungi Paracoccidioides. Hypercalcemia is a rare and not fully understood presentation of this infection. We present a case report of paracoccidioidomycosis associated with hypercalcemia and acute kidney injury (AKI) in an immunocompetent patient.
View Article and Find Full Text PDFApplying nanopore sequencing technology in sp.: a high-quality DNA isolation method for next-generation genomic studies.
Microb Genom
October 2024
Instituto de Medicina Regional (IMR), Universidad Nacional del Nordeste (UNNE), Av. Las Heras 727, (3500) Resistencia, Chaco, Argentina.
Paracoccidioidomycosis is a severe systemic endemic mycosis caused by spp. which mainly affects individuals in Latin America. Progress in genomics has been slow, as evidenced by the incomplete reference databases available.
View Article and Find Full Text PDFNanoformulated CHO-rPb27 vaccine enhances immunity and controls infection, mitigating lung inflammation and dysfunction during experimental Paracoccidioidomycosis in mice.
Int J Biol Macromol
November 2024
Laboratory of Pulmonary Immunology and Mechanics, Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:
Article Synopsis
- * Research is exploring the use of nanotechnology to create new antifungal therapies and vaccines, which can provide targeted delivery and reduce side effects and costs.
- * The study found that the CHO-rPb27 vaccine nanoformulation effectively controls PCM in mice, promoting strong immune responses and reducing tissue damage and lung issues compared to traditional treatment methods.
Paracoccidioidomycosis: a benign cause of avid-FDG-PET/CT bone lesions.
Braz J Infect Dis
September 2024
Universidade Federal do Rio de Janeiro (UFRJ), Departamento de Radiologia, Rio de Janeiro, RJ, Brazil; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil.
Diagnosis of Human Endemic Mycoses Caused by Thermally Dimorphic Fungi: From Classical to Molecular Methods.
J Fungi (Basel)
September 2024
Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain.
Article Synopsis
- Human endemic mycoses are serious fungal infections that can change their form in response to heat, posing risks to both healthy and immunocompromised individuals.
- Diagnosing these infections is challenging due to overlapping symptoms, limited traditional diagnostic methods, and lack of access to reliable testing in affected regions.
- The review discusses key information about these fungi, traditional diagnostic techniques, their pros and cons, and the need for improved diagnostic strategies to lessen the health impact in endemic areas.
Editorial: Global excellence in fungal pathogenesis: Central and South America.
Front Cell Infect Microbiol
September 2024
Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Paracoccidioides spp.: Escape mechanisms and their implications for the development of this mycosis.
Microb Pathog
November 2024
Department of Microbiology and Immunology at Federal University of Alfenas - UNIFAL, Alfenas, MG, CEP 37130-001, Brazil. Electronic address:
Article Synopsis
- Paracoccidioidomycosis (PCM) is a fungal infection caused by various species of the Paracoccidioides fungus, mainly affecting those engaged in rural work.
- The dominant species, Paracoccidioides brasiliensis, has historically been viewed as the primary cause, with research focusing on its interactions with the immune system, including its escape strategies.
- Understanding these interactions and the adhesion molecules used by the fungus can lead to the development of new antifungal treatments aimed at overcoming the challenges posed by the host's immune defenses.
Congestive heart failure associated with itraconazole in a patient with paracoccidioidomycosis.
Braz J Infect Dis
October 2024
Universidade Federal do Triângulo Mineiro, Departamento de Medicina Interna, Unidade de Doenças Infecciosas, Uberaba, MG, Brazil.
Article Synopsis
- * A case study describes a 50-year-old male who developed acute CHF after two months on ITZ, despite having no prior heart issues; tests revealed heart function was compromised.
- * CHF related to ITZ appears to be dose-dependent and improves after stopping the medication; the exact mechanisms behind this side effect remain unclear, but it is believed to involve negative impacts on heart muscle function.
Predicting of novel homoserine dehydrogenase inhibitors against : integrating and approaches.
Future Microbiol
October 2024
Department of Technology, Universidade Estadual de Maringá, Umuarama, PR 87501-390, Brazil.
Article Synopsis
- Researchers aimed to find inhibitors for homoserine dehydrogenase (HSD) to combat paracoccidioidomycosis, a serious infection in Brazil with high mortality rates.
- They performed virtual screenings using modeling tools like Autodock, Molegro, and Gold programs, identifying two promising compounds, HS23 and HS87, which were ranked higher than the substrate and showed no toxicity.
- Experimental assays demonstrated that both compounds exhibited effective minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values, as well as synergistic effects with Amphotericin B (AmB), indicating their potential as viable drug candidates.
Classic Presentation of Oral Paracoccidioidomycosis.
Mycopathologia
September 2024
Palmas General Hospital, Palmas, Tocantins, Brazil.
Disseminated Paracoccidioidomycosis With Severe Ophthalmologic Involvement in a Pediatric Patient: A Case Report.
Pediatr Infect Dis J
January 2025
Departamento de Infectologia Pediátrica, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Paracoccidioides lutzii Infects Galleria mellonella Employing Formamidase as a Virulence Factor.
PLoS Negl Trop Dis
September 2024
Department of Biochemistry and Molecular Biology, Institute of Biological Sciences II, Federal University of Goiás, Goiânia, Brazil.
Article Synopsis
- The formamidase (FMD) enzyme is crucial for the survival of Paracoccidioides lutzii by providing a secondary nitrogen source, especially under stressful conditions.
- Research using Galleria mellonella larvae showed that silencing the fmd gene led to reduced fungal burden, disorganized nodules, and impaired immune response.
- The study concludes that formamidase is a significant virulence factor for P. lutzii since its absence increased the larvae's survival rate, highlighting its role in immune stimulation.
A review of lobomycosis and lobomycosis-like skin disease in cetaceans worldwide, with new data from the Gulf of Guayaquil, Ecuador.
Med Mycol
September 2024
Cetacean Conservation Medicine Group, Peruvian Centre for Cetacean Research (CEPEC), Museo de Delfines, Pucusana, Lima 20, Peru.
Article Synopsis
- Lobomycosis is a chronic fungal skin disease affecting certain types of dolphins, characterized by granulomatous lesions that can become large and ulcerated, primarily caused by the fungus Paracoccidioides ceti.
- Lobomycosis-like disease (LLD) shows similar symptoms but doesn't have a confirmed molecular diagnosis, and there's a focus on its prevalence in bottlenose dolphins in Ecuador.
- Factors like habitat, age, sex, social behavior, and pollution influence the disease's spread, and the impact of these conditions may worsen the challenges faced by already vulnerable dolphin populations.
Histoplasma capsulatum urinary antigen detection in a kidney transplant recipient with acute paracoccidioidomycosis: Case study and literature review.
PLoS Negl Trop Dis
August 2024
Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Background: Paracoccidioidomycosis (PCM) and histoplasmosis are endemic fungal diseases in South America. Both can lead to lung involvement with fungal dissemination progressing to systemic and severe clinical manifestations, especially in immunosuppressed hosts. As the population of immunosuppressed individuals has been rising, a higher occurrence of fungal infections is predicted in this setting.
View Article and Find Full Text PDFDisseminated paracoccidioidomycosis in a captive western black-handed tamarin (Saguinus niger).
J Comp Pathol
October 2024
Centro de Patologia, Instituto Adolfo Lutz, Avenida Dr. Arnaldo, 351, São Paulo, SP 01246-000, Brazil; Laboratório de Patologia Comparada de Animais Selvagens, Departamento de Patologia, Faculdade de Meddicina Veterinária e Zootecnia, Universidade de São Paulo, Avenida Professor Orlando Marques de Paiva, 70, São Paulo, SP 05508-270, Brazil. Electronic address:
Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by Paracoccidioides brasiliensis in a western black-handed tamarin (Saguinus niger) under human care.
View Article and Find Full Text PDFParacoccidioidomycosis: An uncommon cause of discitis in lupus.
Rev Soc Bras Med Trop
July 2024
Universidade Estadual de Campinas, Departamento de Anestesiologia, Oncologia e Radiologia, Campinas, SP, Brasil.
An improved high-performance liquid chromatography (HPLC) method for detection of variations in the hydroxyproline content of tissue homogenates from -infected mice.
J Venom Anim Toxins Incl Trop Dis
July 2024
Department of Microbiology and Immunology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, MG, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) is a serious fungal disease characterized by excessive inflammation and granuloma formation, leading researchers to propose using hydroxyproline (HYP) levels as a marker for assessing disease severity.
- In an experiment with infected mice, histopathological analysis showed significant granuloma and collagen deposits, correlating with high HYP levels, while uninfected controls displayed minimal signs of the disease.
- The findings suggest that measuring HYP could provide an effective method for tracking disease progression and severity not only in PCM but potentially in other conditions involving fibrous tissue degradation.
MDSCs use a complex molecular network to suppress T-cell immunity in a pulmonary model of fungal infection.
Front Cell Infect Microbiol
July 2024
Institute of Science and Technology, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) is a systemic fungal disease found mainly in Latin America, and various immune suppressive mechanisms regulate the host's immune response to it, including tolerogenic dendritic cells and regulatory T-cells.
- This study investigates how receptors like Dectin-1, TLR2, and TLR4 affect the production of immunosuppressive molecules by myeloid-derived suppressor cells (MDSCs) during fungal infections in the lungs.
- Results showed that blocking Dectin-1, TLR2, and TLR4 significantly reduced levels of immunosuppressive molecules such as IL-10 and nitrotyrosine, leading to decreased suppressive activity of MDS
Extrahepatic cholestasis associated with paracoccidioidomycosis: Challenges in the differential diagnosis of biliopancreatic neoplasia.
World J Gastrointest Oncol
June 2024
Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Departamento de Cirurgia e Anatomia, Ribeirão Preto 14049-900, São Paulo, Brazil and Hospital Moriah, Serviço de Endoscopia Digestiva, São Paulo 04084-002, São Paulo, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) can cause complications like extrahepatic cholestasis (EHC), which makes diagnosing and treating patients complicated.
- This study aimed to evaluate how patients with PCM and EHC were managed in a tertiary hospital from 1982 to 2020.
- Among 1645 PCM patients, 40 had EHC, with findings showing similar improvement in both drug-only treatment and combined surgical methods, though EHC recurrence rates were affected by treatment adherence.
The dark side of T2: central nervous system lesions with low signal intensity on T2-weighted imaging.
Radiol Bras
April 2024
Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Article Synopsis
- * A retrospective analysis was conducted on brain and spine MRI examinations from 2015 to 2022, confirming diagnoses through clinical and histopathological correlation.
- * The cases reviewed included various conditions like arteriovenous malformation and metastatic diseases, demonstrating how T2-weighted imaging profiles contributed to more accurate conclusions about the patients' conditions.
Specific Depletion of Myeloid-Derived Suppressor Cells by the Chemotherapy Agent 5-Fluorouracil Enhances Protective Immune Response in Paracoccidioidomycosis.
J Infect Dis
November 2024
Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) is a fungal infection prevalent in Latin America, where certain immune cells (like MDSCs) play a role in suppressing the immune response against the disease.
- Recent findings show that the chemotherapy drug 5-Fluorouracil (5-FU) can effectively reduce MDSCs, leading to improved immune responses and better outcomes in mice infected with the fungus P. brasiliensis.
- The study concludes that using 5-FU to deplete MDSCs could serve as a promising immunotherapy strategy for enhancing immunity against PCM.
Celecoxib exhibits antifungal effect against Paracoccidioides brasiliensis both directly and indirectly by activating neutrophil responses.
Int Immunopharmacol
September 2024
Department of Microbiology and Immunology at Federal University of Alfenas - UNIFAL. Alfenas, MG - Brazil CEP - 37130-001, Brazil. Electronic address:
Article Synopsis
- Celecoxib, an anti-inflammatory drug, is being investigated for its potential direct antifungal effects against the fungus Paracoccidioides brasiliensis, which causes Paracoccidioidomycosis (PCM). !* -
- The study demonstrated that Celecoxib effectively inhibited fungal growth in vitro and in vivo without harming immune cells, suggesting it enhances neutrophil activity against the infection. !* -
- Results indicated that Celecoxib could reduce certain cytokine productions while promoting immune responses that lead to a significant reduction in viable P. brasiliensis cells, indicating its potential as a treatment option for PCM. !*