Microfluidic synthesis of high-valence programmable atom-like nanoparticles for reliable sensing.

Synthesis of programmable atom-like nanoparticles (PANs) with high valences and high yields remains a grand challenge. Here, a novel synthetic strategy of microfluidic galvanic displacement (μ-GD) coupled with microfluidic DNA nanoassembly is advanced for synthesis of single-stranded DNA encoder (SSE)-encoded PANs for reliable surface-enhanced Raman scattering (SERS) sensing. Notably, PANs with high valences (, -valence, = 12) are synthesized with high yields (, >80%) owing to the effective control of interfacial reactions sequentially occurring in the microfluidic system.