Effect of surface functionalization on DNA sequencing using MXene-based nanopores.

As one of the most promising types of label-free nanopores has great potential for DNA sequencing fast detection of different DNA bases. As one of the most promising types of label-free nanopores, two-dimensional nanopore materials have been developed over the past two decades. However, how to detect different DNA bases efficiently and accurately is still a challenging problem.

Loading of DOX into a tetrahedral DNA nanostructure: the corner does matter.

With the rapid development of nanotechnology, various DNA nanostructures have been synthesized and widely used in drug delivery. However, the underlying mechanisms of drug molecule loading into the DNA nanostructure are still elusive. In this work, we systematically investigate the interactions of a tetrahedral DNA nanostructure (TDN) with the anti-cancer drug doxorubicin (DOX) by combining molecular docking and all-atom molecular dynamics simulations.

Ion transport through a nanoporous CN membrane: the effect of electric field and layer number.

Ion transport through a two-dimensional membrane with nanopores plays an important role in many scientific and technical applications (, water desalination, ion separation and nanofiltration). Although there have been many two-dimensional membranes for these applications, the problem of how to controllably fabricate nanopores with proper shape and size still remains challenging. In the present work, the transport of ions through a CN membrane with intrinsically regular and uniformly distributed nanopores is investigated using all-atom molecular dynamic simulations.