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Amino acid inhibition of sodium-dependent synaptosomal proline uptake.

Neurosci Lett

March 1977

Brain-Behavior Research Center (Langley Porter Neuropsychiatric Institute, University of California), Sonoma State Hospital, Eldridge, Calif. 95431, U.S.A.

The inhibitory effects of several amino acids on the synaptosomal uptake of l-proline were studied. Phenylalanine, valine, isoleucine and histidine were most inhibitory (I(50) approximately 100 muM) while leucine, serine and tyrosine had lesser inhibitory effects. The inhibition by phenylalanine and valine was of the competitive type.

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