63 results match your criteria: "Somogyi Phenomenon"
Study of phenanthrenes from their unique mass spectrometric behavior through quantum chemical calculations to liquid chromatographic quantitation.
Talanta
January 2025
Institute of Pharmaceutical Analysis, Faculty of Pharmacy, University of Szeged, Somogyi utca 4, H-6720, Szeged, Hungary; Department of Forensic Medicine, Albert Szent-Györgyi Health Centre, Kossuth Lajos sgt. 40, H-6724, Szeged, Hungary. Electronic address:
Phenanthrenes and their derivatives have biological relevance owing to their antimicrobial, antioxidant, and cytotoxic effects on cancer cells. They can be efficiently analyzed through ultrahigh-performance liquid chromatography coupled to tandem high-resolution mass spectrometry (UHPLC-MS/HRMS). Herein, we first studied the unique fragmentation behavior of phenanthrenes based on direct infusion MS/HRMS analysis.
View Article and Find Full Text PDFAn international comparison of gender differences in mental health among higher-education students during the first wave of the COVID-19 pandemic: a multilevel design.
Arch Public Health
December 2023
Interface Demography, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, 1050, Belgium.
Article Synopsis
- - Mental health issues are significant among college students, showing different patterns between genders; females tend to experience more depression, while males often face alcohol abuse issues.
- - A study using data from 26 countries during the COVID-19 pandemic found that female students reported higher levels of depression, while male students had increased alcohol consumption.
- - The research indicates that government restrictions during the pandemic contributed to more depressive feelings in female students, underscoring the importance of considering gender differences in mental health studies.
Palladium(II) and Platinum(II) Bis(Stibinidene) Complexes with Intramolecular Hydrogen-Bond Enforced Geometries.
Chempluschem
May 2024
Department of General and Inorganic Chemistry, FCHT, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.
Article Synopsis
- The study investigated the coordination capabilities of two specific stibinidene compounds with palladium(II) and platinum(II), leading to the creation of seven new complexes.
- These complexes were characterized using various analytical techniques, revealing differences in the orientation of aromatic rings and introducing complexities in their structures due to bulkiness and possible hydrogen bonding interactions.
- Theoretical analysis, including TD-DFT calculations, was performed to explain the UV-vis spectra of the complexes and highlight how their properties vary based on the ligands and metal charges.
PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content.
Cardiovasc Diabetol
March 2023
Translational Medicine Institute, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Article Synopsis
- Recent studies indicate that the TyG index and HOMA-IR may have different levels of predictive value for coronary artery calcification, despite both being indicators of insulin resistance.
- The research analyzed 39 women with specific PNPLA3 rs738409 genotypes to investigate how liver fat content influences these insulin resistance indices using various metabolic assessments.
- Findings revealed that the GG genotype, associated with a higher risk of non-alcoholic fatty liver disease, significantly disrupted the correlation between the TyG index and HOMA-IR, while both indices remained strongly correlated with hepatic triglyceride content.
Confirmation of the Absence of Somogyi Effect in Patients with Type 2 Diabetes by Retrospective Continuous Glucose Monitoring Systems.
Int J Endocrinol
October 2022
Department of Endocrinology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Article Synopsis
New strategies of diagnostic and therapeutic approach to emergencies in the evolution of patients with diabetes mellitus (Review).
Exp Ther Med
February 2022
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Article Synopsis
- Diabetes mellitus is a widely prevalent disease that significantly strains healthcare systems due to its complex acute and chronic complications, leading to higher hospitalization rates and costs.
- Patients with diabetes often face severe acute complications, such as hypoglycemia, diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic state, necessitating frequent emergency department visits.
- Effective treatment of these complications in the emergency department requires immediate assessment of vital functions and careful monitoring of blood sugar and electrolytes, alongside targeted therapeutic interventions.
Suspecting unwitnessed hypoglycaemia.
Pract Neurol
April 2021
Department of Neurology and Stroke Medicine, St George's Hospital Atkinson Morley Regional Neuroscience Centre, London, Greater London, UK.
Article Synopsis
- Hypoglycaemic coma can show symptoms similar to a stroke, leading to acute neurological dysfunction.
- The condition may appear to be normal blood sugar levels due to the body's compensatory mechanisms, like the Somogyi phenomenon.
- Clinicians should look for specific changes on MR brain scans in patients with a history of recurrent hypoglycaemia, as quick identification and treatment can improve outcomes and reverse radiological issues.
Photomorphogenesis in the Picocyanobacterium Includes Increased Phycobilisome Abundance Under Blue Light, Phycobilisome Decoupling Under Near Far-Red Light, and Wavelength-Specific Photoprotective Strategies.
Front Plant Sci
March 2021
Balaton Limnological Institute, Centre for Ecological Research, Tihany, Hungary.
Article Synopsis
- Photomorphogenesis is the way photosynthetic organisms adapt to different lighting conditions by changing their growth and metabolic processes, focusing on how a common cyanobacterium adjusts to various light colors.
- The study showed that these cyanobacteria can effectively alter pigment composition, antenna size, and photosystem ratios to enhance photosynthesis, but they struggle with blue and near far-red light compared to red or orange light.
- Interestingly, under specific conditions, weak light can induce partial decoupling of the light-harvesting antenna, a process usually triggered by strong light, suggesting that these organisms can optimize performance even in less-than-ideal light situations.
[Pre-programmed genes].
Orv Hetil
August 2017
Orvosi Biológiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Somogyi u. 4., 6720.
Cells feel good and carry on perfect functions when they contain the right types of proteins in the right concentration, at the right time and sites. There are mechanisms that ensure the right level of gene expression in the different cell types: the formation of protein molecules based on the DNA-encoded genetic information. Gene expression can also be regulated through the compactness of chromatin, i.
View Article and Find Full Text PDFRebound hyperglycaemia in diabetic cats.
J Feline Med Surg
August 2016
School of Veterinary Science, The University of Queensland, Queensland, Australia
Article Synopsis
Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.
PLoS One
December 2014
Department of Anatomy, Histology and Embryology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.
Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting protecting role during traumatic injuries or inflammatory processes of the central nervous system. Although increasing evidence is available on its presence and protecting function in various peripheral tissues, little is known about the role of PACAP in formation of skeletal components. To this end, we aimed to map elements of PACAP signalling in developing cartilage under physiological conditions and during oxidative stress.
View Article and Find Full Text PDFMechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures.
Cell Signal
March 2014
Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98, H-4032 Debrecen, Hungary. Electronic address:
Article Synopsis
- Biomechanical stimuli are crucial for the development of articular cartilage in early fetuses and affect adult cartilage cell function; this study investigates how these mechanical forces influence chondroprogenitor cells in vitro.
- Chondroprogenitor cells from chicken embryos were subjected to mechanical loading using a bioreactor, which significantly improved cartilage matrix production and the expression of key cartilage components like collagen type II and aggrecan.
- The study highlights that these effects are mediated through enhanced activity of the PKA pathway and the transcription factor Sox9 while showing that certain cAMP mediators and the phosphatase PP2A play roles in cartilage formation under mechanical load.
Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation.
PLoS One
July 2014
Institute of Human Genetics, University of Regensburg, Regensburg, Germany ; Department of Ophthalmology, University of Cologne, Cologne, Germany.
Article Synopsis
- Neuronal ceroid lipofuscinosis (NCL) is a neurodegenerative disorder leading to symptoms like vision loss, mental decline, and seizures, with significant brain atrophy observed in patients and animal models.
- * In a study using CLN6 (nclf) mice, researchers found severe retinal degeneration and changes in glial cells, particularly an increase in reactive Müller glia and transformed microglia that corresponded with visual impairment.
- * Dietary supplements like curcumin and DHA showed potential in reducing microglial activation and partially improving retinal function, suggesting their role in managing the disease's progression.
[Morning hyperglycemia in children and adolescents with type 1 diabetes and different modes of therapy: an evaluation of the DPV data pool].
Klin Padiatr
November 2012
Klinik für Kinder- und Jugendmedizin, St. Vincenz-Krankenhaus, Paderborn.
Article Synopsis
- Children and adolescents with type 1 diabetes often experience early morning high blood sugar levels, primarily due to the dawn phenomenon, lack of insulin, or the Somogyi phenomenon.
- An analysis of 5,839 patients revealed that 24.2% exhibited morning hyperglycemia, with a significantly lower occurrence of dawn phenomenon and insulin lack in those treated with insulin pumps compared to other insulin therapies.
- The study highlights that insulin pump treatment not only reduces morning hyperglycemia but also results in better blood glucose control during early morning hours.
The dawn phenomenon and the Somogyi effect - two phenomena of morning hyperglycaemia.
Endokrynol Pol
March 2012
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
Article Synopsis
- Morning hyperglycemia in diabetics can be due to the dawn phenomenon, the Somogyi effect, or inadequate glycemic control.
- The dawn phenomenon is linked to decreased insulin or the effects of previous insulin wearing off, while the Somogyi effect occurs with too much insulin leading to rebound high blood sugar.
- Diagnosing these issues involves checking plasma glucose levels at night or using continuous monitoring, with optimal diabetes control being the best prevention for both conditions.
Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain.
Brain Behav Immun
March 2011
Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide 5005, Australia.
Article Synopsis
- - Recent research shows that immune cells from the peripheral system play a role in causing increased pain sensitivity in neuropathic pain by moving into the central nervous system (CNS)! - In a rat model of chronic nerve injury, transferring immune cells from high pain rats to those with low pain resulted in a significant increase in pain sensitivity, but only in animals that already had pain sensitivity! - Analysis revealed that these transferred immune cells migrate to the spleen and influence other immune cells to move to the CNS, actively contributing to heightened pain responses rather than just being present without effect!
[Elevated serum dipeptidyl peptidase-4 activity in type 1 diabetes mellitus: a direct comparison].
Orv Hetil
May 2010
Semmelweis Egyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi utca 46. 1088.
Article Synopsis
- Dipeptidyl peptidase-4 (DPP-4) is crucial for carbohydrate metabolism by breaking down incretin hormones.
- The study measured DPP-4 activity in fasting and after meals in patients with type 1 and type 2 diabetes, as well as healthy controls.
- Results showed higher DPP-4 activity in type 1 diabetic patients compared to type 2 and controls, suggesting that diabetes type, not blood sugar levels, influences DPP-4 enzyme activity, potentially linked to autoimmune factors.
Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster.
Proc Natl Acad Sci U S A
March 2009
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, PO Box 521, H-6701, Szeged, Hungary.
Article Synopsis
- Drosophila blood cells (hemocytes) are crucial for immune responses, producing antimicrobial peptides, engulfing bacteria, and encapsulating larger foreign objects like parasitic eggs.
- Lamellocytes, which are large specialized cells involved in the encapsulation response, share similarities with granuloma formation in vertebrates, but their origin had been unclear.
- Recent findings indicate that a specific population of sessile blood cells, released during parasitoid wasp infections, is a key source of lamellocytes, suggesting a new hematopoietic compartment in Drosophila.
Article Synopsis
- A new method for detecting amphetamine derivatives in human serum and urine using gas chromatography-mass spectrometry has been developed, utilizing N-methyl-bis(trifluoroacetamide) (MBTFA) for rapid chemical modification.
- The study investigated how different amphetamines reacted to varying concentrations of undiluted and diluted MBTFA, finding that the analytes could be categorized into three groups based on their reaction intensity.
- The results indicated that primary amines reacted more readily to MBTFA concentration changes than secondary amines, leading to insights that could improve the efficiency of similar analytical methods.
Nocturnal hypoglycaemias in type 1 diabetic patients: what can we learn with continuous glucose monitoring?
Diabetes Metab
November 2007
Service of Endocrinology, Diabetology and Metabolism, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland.
Article Synopsis
- The study focuses on the high incidence of nocturnal hypoglycaemias (NH) among type 1 diabetic patients (T1DM) and evaluates the effectiveness of self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGMS) in detecting and managing these episodes.
- A significant 67% of participants experienced NH, with many being unnoticed, highlighting the limitations of SMBG, especially at bedtime compared to CGMS monitoring.
- Results indicated that SMBG at bedtime is nearly as effective as monitoring glucose levels at 3 AM in predicting NH, and after using CGMS for 6-9 months, the suspicion of NH significantly decreased from 60% to 14%.
Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subject.
Ther Drug Monit
August 2006
Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, Australia.
Article Synopsis
- The study investigates whether the increased oral clearance of rac-methadone during the early phase of maintenance treatment is due to changes in bioavailability or if it is stereoselective.
- Researchers developed a sophisticated assay using stereoselective high-performance liquid chromatography and mass spectrometry to quantify methadone enantiomers and a stable isotope labeled version.
- The assay demonstrated high accuracy and precision for measuring different methadone forms and was successfully applied to a patient receiving chronic oral methadone treatment.