6,121 results match your criteria: "Solitary Pulmonary Nodule"

Comparison of different localization needles and postures in localization of pulmonary nodules.

J Cardiothorac Surg

December 2024

Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, Nanjing North Street, Shenyang, 110002, Liaoning, P.R. China.

Background: With advancements in imaging testing and surgical procedures, an increasing number of nodules with smaller diameters and deeper locations have been deemed suitable for surgical intervention. The preoperative localization of these nodules has become essential. In this retrospective single-center study, we aimed to compare the effectiveness and patient comfort associated with the use of a four-hook needle versus a hook-wire needle for preoperative localization.

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Background: Diffusion-weighted imaging (DWI) can be used for quantitative tumor assessment. DWI with different models may show different aspects of tissue characteristics.

Objective: To investigate the diagnostic performance of parameters derived from monoexponential, biexponential, stretched exponential magnetic resonance diffusion weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in differentiating benign from malignant solitary pulmonary lesions (SPLs).

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The Winner and still champion: Nodule volume doubling times.

Eur J Cancer

December 2024

Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

There have been enormous advances in the approach to assessing malignancy status of indeterminate pulmonary nodules including risk models, image based biomarkers and numerous types of biologic and molecular markers. All of these have the advantage of guiding further workup once the nodule is identified. The traditional method, especially for smaller nodules relies primarily on assessing whether a nodule changes in size over time and is a feature in virtually every management protocol for both screen detected as well as incidentally detected nodules.

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CT Radiomic Nomogram Using Optimal Volume of Interest for Preoperatively Predicting Invasive Mucinous Adenocarcinomas in Patients with Incidental Pulmonary Nodules: A Multicenter, Large-Scale Study.

Technol Cancer Res Treat

December 2024

Department of Thoracic Surgery, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Affiliated Tumor Hospital of Shanxi Medical University, Taiyuan, P. R. China.

Introduction: This study evaluated the efficacy of radiomic analysis with optimal volumes of interest (VOIs) on computed tomography images to preoperatively differentiate invasive mucinous adenocarcinoma (IMA) from non-mucinous adenocarcinoma (non-IMA) in patients with incidental pulmonary nodules (IPNs).

Methods: This multicenter, large-scale retrospective study included 1383 patients with IPNs, 110 (8%) of whom were pathologically diagnosed with IMA postoperatively. Radiomic features were extracted from multi-scale VOI subgroups (VOI, VOI, VOI , and VOI ).

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Laser-guided percutaneous microwave ablation for lung nodules: a promising approach with reduced operation time.

BMC Surg

December 2024

Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, China.

Background: Pulmonary nodule ablation is an effective method for treating pulmonary nodules. This study is based on the traditional CT-guided percutaneous microwave ablation (MWA) of pulmonary nodules. By comparing laser guidance technology with freehand method, this study aims to explore the safety and efficacy and patients' pain scores of these two approaches.

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Background: Non-neoplastic ground-glass nodules (GGNs) generally decrease in size or density during follow-up; however, some exhibit the opposite effect (and show progressive changes), which can lead to unnecessary resection. This study sought to determine the progressive changes in non-neoplastic GGNs using follow-up computed tomography (CT).

Methods: This cross-sectional study included 70 patients diagnosed with pathologically confirmed non-neoplastic GGNs from January 2017 to March 2023.

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Pulmonary sclerosing pneumocytoma is a rare benign neoplasm typically seen in middle-aged women. The exact preoperative diagnosis is quite challenging considering its nonspecific clinical and radiologic features along with complex histology. Moreover, obtaining an exact histopathological diagnosis can be difficult especially with the small biopsy specimens.

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Background: Differences between virtual bronchoscopic navigation (VBN) systems and their impacts on the diagnostic yield of transbronchial biopsy (TBB) of peripheral pulmonary nodules (PPNs) remain unclear.

Objectives: To compare the Synapse 3D system (Version 4.4, Fujifilm, Japan) and DirectPath system (Version 2.

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Construction of a risk prediction model for isolated pulmonary nodules 5-15 mm in diameter.

Transl Lung Cancer Res

November 2024

Department of Pulmonary and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army of China, Fuzhou, China.

Background: Based on current technology, the accuracy of detecting malignancy in solitary pulmonary nodules (SPNs) is limited. This study aimed to establish a malignant risk prediction model for SPNs 5-15 mm in diameter.

Methods: We collected clinical characteristics and imaging features from 317 patients with SPNs 5-15 mm in diameter from the 900th Hospital of the Joint Logistic Support Force as a training cohort and 100 patients with SPNs 5-15 mm in diameter as a validation cohort.

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Background: This study explores the value of interlobar fissure semilunar sign(IFSS) based on multifactor joint analysis in predicting the invasiveness of ground glass nodules(GGNs) with interlobar fissure attachment in the lungs.

Methods: This was a retrospective analysis of clinical data and CT images of 203 GGNs attached to the interlobar fissures confirmed by surgery and pathology. According to pathological results, those GGNs were divided into three groups: glandular precursor lesion (atypical adenomatous hyperplasia/adenocarcinoma in situ), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC).

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Article Synopsis
  • The study evaluates how F-FDG-PET/CT imaging combined with clinicopathological factors can help differentiate between primary lung cancer (PLC) and breast cancer metastasis (BCM) in patients with solitary pulmonary nodules (SPNs) following breast cancer treatment.* -
  • It involved 120 breast cancer patients, comparing clinicopathological characteristics and imaging features to identify significant differences, particularly in tumor markers and metabolic activities related to SPNs.* -
  • Key findings suggest that certain imaging features and serum markers, like SUV and specific signs on CT scans, are predictive factors that can aid in accurately diagnosing SPNs in this patient population.*
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Article Synopsis
  • A study in China (Sept-Oct 2022) assessed the knowledge, attitude, and practice (KAP) of 1209 adults regarding pulmonary nodules, revealing poor knowledge but moderate attitude and practice levels.
  • The KAP scores indicated that participants averaged 5.95/12 in knowledge, 29.05/40 in attitude, and 23.72/45 in practice, showing a clear need for improvement.
  • The findings suggest that enhancing knowledge through health education could positively influence attitudes and behaviors regarding pulmonary nodules among Chinese adults.
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Article Synopsis
  • The study assesses the effectiveness of an AI algorithm for detecting pulmonary nodules using ultra-low-dose CT scans in emergency departments, highlighting its role in improving diagnosis.
  • A total of 870 patients were included, with the AI identifying 104 true positives but also generating 1,758 false positives, indicating a high trade-off between missed nodules and unnecessary alerts.
  • The conclusion emphasizes that while AI significantly increases the detection of potentially harmful nodules (5.8 times more), it also raises the rate of false positives (42.9 times more), which can lead to additional unneeded follow-ups.
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Plasma nicotine and its metabolite as biomarkers of tobacco exposure and their relevance to pulmonary nodule.

Biomark Med

December 2024

Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan Districts, Hefei, Anhui, 230032, China.

Article Synopsis
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Clinical characteristics of pulmonary cryptococcosis patients with different immune statuses: A 10-year multicenter retrospective study in China.

Respir Med

December 2024

Department of Pulmonary and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, PR China. Electronic address:

Background And Objective: We aimed to evaluate clinical characteristics and therapeutic efficacy of pulmonary cryptococcosis (PC) in patients with different immune status in a large multicenter population to support appropriate clinical management of this public health threat.

Methods: We retrospectively investigated the medical records of 510 patients with PC from January 2014 to June 2023 in 10 representative regional tertiary teaching hospitals in Hubei province of China, and clinical data of these patients were then stratified by different immune statuses.

Results: Immunocompetent (IC) patients accounted for 68.

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Highly Sensitive and Specific Panels of Plasma Exosomal microRNAs for Identification of Malignant Pulmonary Nodules.

Clin Respir J

November 2024

Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, China.

Article Synopsis
  • The study focuses on the use of plasma exosomal microRNAs as potential biomarkers for identifying malignant solitary pulmonary nodules (SPNs), which are often detected via CT scans.
  • Researchers identified exosomal miRNAs from patients with confirmed SPNs and selected candidate miRNAs for further testing, ultimately determining diagnostic values through quantitative PCR and AUROC analysis.
  • Results showed that the combination of microRNAs produced high sensitivity and specificity rates for malignant SPNs, particularly a combination of miR-1-3p and miR-99a-5p, which achieved 100% for both metrics in detection.
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Accurate segmentation of lung lesions in CT-scan images is essential to diagnose lung cancer. The challenges in lung nodule diagnosis arise due to their small size and diverse nature. We designed a transformer-based model EDTNet (Encoder Decoder Transformer Network) for PNS (Pulmonary Nodule Segmentation).

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Background: Pain is a relatively common complication after hook-wire puncture localization. However, the problem of pain occurrence following this localization procedure has not been sufficiently examined. In this prospective study, we aimed to investigate the incidence and risk factors associated with acute pain after preoperative CT-guided hook-wire puncture localization of pulmonary nodules.

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Participant management in a lung cancer screening (LCS) depends on the assigned Lung Imaging Reporting and Data System (Lung-RADS) category, which is based on reliable detection and measurement of pulmonary nodules. The aim of this study was to compare the agreement of two AI-based software tools for detection, quantification and categorization of pulmonary nodules in an LCS program in Northern Germany (HANSE-trial). 946 low-dose baseline CT-examinations were analyzed by two AI software tools regarding lung nodule detection, quantification and categorization and compared to the final radiologist read.

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Background: A screening tool was devised to aid the diagnosis and treatment of ground-glass nodules (GGNs).

Methods: The current ambispective cohort study included retrospective collation of 20 variables synthesizing a patient's clinical characteristics, serum tumor markers, and CT results, which allowed division into noninvasive (benign, atypical adenomatous hyperplasia, and adenocarcinoma in situ) and invasive (minimally invasive and invasive adenocarcinomas) tumors to build a prediction nomogram and GGN screening scale. The model was verified internally.

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Article Synopsis
  • The study focuses on differentiating benign and malignant pulmonary nodules, which are common lung lesions, using a deep learning classification algorithm.
  • A total of 120 patients with detected pulmonary nodules were analyzed, comparing the deep learning model's effectiveness to that of radiologists based on pathological results.
  • The results showed that while the deep learning model performed slightly better in terms of accuracy, sensitivity, and specificity, there was no significant difference between its diagnostic outcomes and those of human radiologists.
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