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Identification of an α-(16)-Mannosyltransferase Contributing To Biosynthesis of the Fungal-Type Galactomannan α-Core-Mannan Structure in Aspergillus fumigatus.
mSphere
December 2022
Department of Biotechnology and Life Sciences, Sojo Universitygrid.412662.5, Kumamoto, Japan.
Article Synopsis
- Fungal-type galactomannan from Aspergillus fumigatus consists of specific linkages of mannan and galactofuran, with recent findings highlighting the involvement of CmsA and CmsB in its α-core-mannan biosynthesis, yet the relevant α-(1→6)-mannosyltransferase remained unidentified.
- Through analyzing gene disruption strains, researchers uncovered that the absence of this mannosyltransferase leads to impaired mycelial growth and reduced spore production, indicating its crucial role in fungal development.
- The study identified AnpA as the likely α-(1→6)-mannosyltransferase, showing distinct activity and substrate recognition compared to similar