TLR/NLRP3 inflammasome signaling pathways as a main target in frailty, cachexia and sarcopenia.

Mobility disability is a common condition affecting older adults, making walking and the performance of activities of daily living difficult. Frailty, cachexia and sarcopenia are related conditions that occur with advancing age and are characterized by a decline in muscle mass, strength, and functionality that negatively impacts health. Chronic low-grade inflammation is a significant factor in the onset and progression of these conditions.

The Learning Curve in Urogynecology and Functional Urology: A Systematic Review.

Introduction And Hypothesis: When adopting new methods, surgeons may experience a period of complexity and longer operation times because of their inexperience. This period is known as the "learning curve." This study was aimed at systematically reviewing the current literature on functional urology learning curves.

The Effect of Risk Factors and Clinical Complications of Chronic Kidney Disease (CKD) on Renal Arterial Resistive Index (RRI).

Background: Chronic Kidney Disease (CKD) is a known risk factor for End-Stage Renal Disease (ESRD) and Cardiovascular Diseases (CVD). Renal Doppler Ultrasound (RDU) can detect early renal involvement in CKD using the Renal Resistive Index (RRI).

Aims: This study aimed to investigate the effects of risk factors and clinical complications associated with CKD on RRI among patients with different stages of CKD.

Urban and rural residence: their influence on food group consumption in Iran.

Background: Urbanization is expanding in Iran, leading to the emergence of three distinct socio-geographical areas: urban, rural, and suburban areas. These different areas may exhibit significant variations in dietary patterns. This study investigates the association between people's place of residence and their consumption of different food groups.

COVID-19 pandemic effects on the emergency medical services utilization: A systematic review protocol.

To the best of our knowledge, to date, there is no comprehensive review study that has explored the effects and impacts of the COVID-19 pandemic on emergency medical services (EMS) systems. Therefore, this systematic review will be conducted to investigate the effects of the COVID-19 pandemic on the delivery of pre-hospital emergency care services in EMS agencies. To achieve the study aims, electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar will be searched for related studies.

Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross-Sectional Study.

Background And Aims: Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is also an appropriate predictor for revascularization strategy in patients with complex CAD. The aim of this study is to investigate the correlation between rs1801131 and rs1801133 with the severity of coronary lesions in patients with ST‑Elevation Myocardial Infarction (STEMI) and Non‑ST‑Elevation Myocardial Infarction (NSTEMI) based on the SYNTAX score.

The effect of addressing the top 10 global causes of death on life expectancy in 2019: a global and regional analysis.

Background: The life expectancy (LE) index reflects health changes in society, highlighting trends in health quality and quantity. This study focused on analysing the impact of the top 10 causes of death on the global increase in LE in 2019.

Methods: Data on the top 10 causes of death in 2019 were obtained from the Global Burden of Disease website and a period life table was used to assess how eliminating these causes would impact LE.

The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021.

Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from 1990 to 2021. We analysed publicly accessible data from the Global Burden of Disease 2021 study to present findings on the incidence, deaths, and disability-adjusted life years (DALYs) associated with prostate cancer.

Extract Affects Acute Kidney Injury Caused by Rhabdomyolysis in Rats Through TNF/NF-κB Signaling Pathway.

Due to the anti-inflammatory and antioxidant properties of the and the pathological mechanisms of rhabdomyolysis in the kidney, this plant can be used to improve the symptoms of this disease. Then, in this study, we investigated the effects of this herb in improving kidney injury by rhabdomyolysis. Animals were divided into five groups: control, glycerol (received it for rhabdomyolysis induction), extract (received 12 mg/kg extract), and treatment groups with dexamethasone (0.

Application of Transcutaneous Electrical Acupoint Stimulation (TEAS) for Management of Postoperative Pain After Gynecological Surgeries: A Meta-Analysis.

Purpose: Transcutaneous Electrical Acupoint Stimulation (TEAS) is a noninvasive technique that involves the application of electrical stimulation to specific acupoints on the skin. This meta-analysis aimed to evaluate the clinical efficacy of TEAS in alleviating postoperative pain after gynecological surgeries.

Method: A systematic search of multiple electronic databases was carried out to identify relevant studies that investigated the use of TEAS for postoperative pain management in gynecological surgery settings.

Improving pubertal health education for adolescent girls through a gamified learning approach.

Background: Adolescence is a crucial phase in a person's life. The purpose of this study was to evaluate the efficacy of gamification in the education of teenage females on pubertal health.

Methods: This clinical trial, conducted on 90 adolescent girls in XXX, XXX, during the 2023-2024 year, used a multistage cluster sampling method to assign participants randomly to intervention and control groups.

Combined effects of reflexology massage and respiratory relaxation on pain following chest tube removal in heart surgery patients.

Background And Aim: Removing the chest tube in cardiac patients after surgery is one of the worst experiences of hospitalization in the intensive care units. Various pharmacological and non-pharmacological methods are available to control pain in these patients. This study aimed to investigate the combined effect of reflexology massage and respiratory relaxation on pain following chest tube removal in cardiac surgery patients of Shahid Beheshti Hospital in Shiraz, Iran, in 2023.

Evaluating food contact surface and its influence on restaurant health ratings.

Controlling and maintaining the cleanliness of the working environment in restaurants is crucial. The aim of this study was to determine the level of contamination on food contact surfaces in restaurants. A total of 28 restaurants were surveyed, and 500 samples were taken from food contact surfaces that appeared clean and ready for use.

Health literacy and its relationship with mental health and quality of life in freshmen students.

Introduction: Health literacy is an effective indicator of people's health level. Therefore, this study aimed to investigate health literacy and its relationship with mental health and quality of life in first-year medical sciences students.

Methods And Materials: The cross-sectional study was conducted on freshmen- students of Babol University of Medical Sciences, Iran.

Investigating the effectiveness of whole-virus, protein-based, and vector-based SARS-CoV-2 vaccines on the rates of COVID-19 infection, hospitalization, and mortality: a historical cohort study in Iran.

Background: Each of the Coronavirus disease 2019 (COVID-19) vaccines has its characteristics that can affect their effectiveness in preventing hospitalization and patient mortality. The present study aimed to determine the effectiveness of COVID-19 vaccines, including whole-virus, protein-based, and vector-based on COVID-19 infection, hospitalization, and mortality.

Methods: The current cohort study was conducted using the data of all people who received at least two doses of each type of COVID-19 vaccine from March 2020 to August 2022 in Khorasan Rzavi province.

Determinants of physical activity among female students based on the transtheoretical model.

This study investigates factors influencing physical activity based on the Transtheoretical model (TTM) among adolescents. This study was conducted on 745 individuals between the ages of 12 and 16 years and was analyzed using a generalized linear model (GLM) approach with appropriate link functions using both classical and Bayesian frameworks. The results show that in model 1, the probit link function is a more appropriate approach to determine the risk factors for physical activity.

Short-term exposure to PM pollution in Iran and related burden diseases.

The objective of this study was to estimate the health effects attributed to PM exposure in southwest of Iran. In order to estimate HA-CVD, HA-RD, LC-M, I-As in children, RAD, and WDL, the exposure-response function method was used. The annual mean of PM regularly exceeded 5.

Prevalence and Factor Influencing Intimate Partner Violence against Women during COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

Background: It seems that the prevalence of intimate partner violence increased during the COVID-19 pandemic. To investigate the prevalence of different types of IPV and its contributing factors on a global scale during the COVID-19 pandemic.

Methods: This is a systematic review and meta-analysis study.

The Impact of Ankle Mobilization Techniques on Static Stability in Individuals With Acute Inversion Ankle Sprain: A Randomized Clinical Trial.

Objective: The purpose of the study was to compare the impact of the mobilization techniques and mobilization with movement techniques on static balance in individuals with acute inversion ankle sprain.

Methods: Volunteers with acute inversion ankle sprain ( = 40) were equally and randomly assigned to 2 groups. Participants in intervention group I received the Mulligan mobilization with movement techniques, whereas participants in intervention group II underwent the Maitland mobilization techniques.

Relationship Between Clinical Decision-Making and Moral Distress in Neonatal Intensive Care Unit Nurses: A Multicenter Cross-Sectional Correlational Descriptive Study.

Background: In the neonatal intensive care unit (NICU), nurses care for premature and critically ill neonates, interact with parents, and make clinical decisions regarding the treatment of neonates in life-threatening conditions. The challenges of managing unstable conditions and resuscitation decisions can cause moral distress in nurses.

Purpose: This study aims to determine the relationship between clinical decision-making and moral distress in NICU nurses.

Pre-hospital emergency: analyzing the status of medication and equipment in pre-hospital emergency bases.

Background: Pre-hospital emergency care is a comprehensive system that responds to the medical needs of injured patients outside of health care centers. The right equipment and facilities are necessary to provide proper and satisfactory services. Due to the increase in pre-hospital emergency services and the high prevalence of emergency events, the present study was conducted to investigate the status of medication and equipment in pre-hospital emergency bases and compare it with national standards.

Exploring the relationship between facilitating factors and adherence to nursing ethical standards.

Background: Professional ethics is a cornerstone of the nursing profession, with its observance closely linked to the enhancement of nursing services and the satisfaction of service recipients. This study aimed to assess nurses' compliance with professional ethical codes and its relationship with factors that facilitate such compliance.

Methods: This descriptive-analytical, cross-sectional study was conducted in 2021 in a hospital located in southern Iran.