Exploring the Therapeutic Potential: Ta'līq al-'Alaq (Leech Therapy) for Qarha Khabītha (Non-Healing Ulcer): A Case Study.

Non-healing ulcers are chronic lesions, often found on the lower extremities, persisting for over three months despite adequate care. They are associated with systemic diseases or local disorders and significantly impact the quality of life, often resisting conventional treatments, which can be costly and pose side effects. Ta'liq al-Alaq (leech therapy), a regimen in Ilaj-Bit-Tadbeer of Unani medicine, offers an alternative based on the principle of Istifrāgh (expulsion of morbid humours).

Brain spatial reconciliation through multisensory integration in the impact of pandemic fatigue on workplace.

The COVID-19 pandemic has highlighted the prevalence of fatigue, reduced interpersonal interaction, and heightened stress in work environments. The intersection of neuroscience and architecture underscores how intricate spatial perceptions are shaped by multisensory stimuli, profoundly influencing workers' wellbeing. In this study, EEG and VR technologies, specifically the , were employed to gather data on perception and cognition.

Wound healing potential of mouth gel containing isopimarane diterpene from rhizomes for treatment of oral stomatitis.

Background: Oral ulcers have an impact on 25% of the global population including patients who are suffering from chemotherapy and radiotherapy treatments. L. has been traditionally used for treatment of mouth sores and tongue blisters.

Effect of Smell and Taste of Milk on Feeding Parameters in Preterm Neonates: An Updated Meta-Analysis.

Smell and taste sensations have been linked to positive outcomes in the feeding of premature infants, though the impact on the time required to transition to oral feeding remains unclear. This study aimed to evaluate the beneficial effects of smell and taste interventions on clinical outcomes in preterm infants. We conducted a search in PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials from inception through September 2024 for randomized controlled trials (RCTs) examining the effects of smell and taste on clinical outcomes in preterm infants with a gestational age of less than 34 weeks.

Chronic rhinosinusitis with nasal polyps (CRSwNP) symptom verbal response scales: content validity testing for use in adults with CRSwNP.

Background: PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options. This study assessed content validity and meaningful change in five verbal response scales (VRSs) used to assess chronic rhinosinusitis with nasal polyp (CRSwNP) symptom severity.

Methodology: This qualitative, semi-structured interview study recruited adults from the US, Germany, and China with confirmed moderate-to-severe CRSwNP.

Smells like … no evidence that odors influence the attentional blink.

The attentional blink (AB) paradigm is frequently used to investigate temporal attention. Essentially, rapid serial visual streams of several distractors and two targets are presented. The accuracy in detecting the second target stimulus (T2) decreases in the time window between 100 and 500 ms following accurate detection of the first target stimulus (T1).

[Investigation on tastes, properties, and traditional efficacy of Mongolian medicines of genus Artemisia based on pharmacophylogeny].

The genus Artemisia is one of the most abundant groups of medicinal plants in the Asteraceae family. Based on the theoretical basis of the pharmacophylogeny, the phylogenetic analysis, association analysis and other methods were used to systematically sort out the genetic relationships, properties, tastes, chemical constituents, and traditional efficacy of Mongolian medicines of genus Artemisia(MMA). The correlation and regularity were discussed.

Brief Outpatient Rehabilitation Program for Post-COVID-19 Condition: A Randomized Clinical Trial.

Importance: Post-COVID-19 condition (PCC) is emerging as a common and debilitating condition with few treatment options.

Objective: To assess the effectiveness of a brief outpatient rehabilitation program based on a cognitive and behavioral approach for patients with PCC.

Design, Setting, And Participants: Patients with mild to moderate PCC were randomized 1:1 to an established transdiagnostic rehabilitation program or care as usual at a single referral center recruiting from the region of the South-Eastern Norway Regional Health Authority.

Novel Scent Enrichment Enhances Socio-Sexual and Olfactory Behaviors in Zoo-Housed Gentle Lemurs.

The Alaotran gentle lemur (Hapalemur Alaotrensis) is one of the most endangered primates in the world and shows a low success rate in captive breeding programmes. We tested a novel scent enrichment, made up of a synthesized mixture likely conveying information about female fertility, on four unsuccessful breeding pairs (n = 8 subjects) living at the Jersey, Birmingham, London (United Kingdom) and Mulhouse (France) zoos. We evaluated the effects of the scent enrichment on behavior (515 h of observation) and fecal endocrinology (cortisol and testosterone measurements) (n = 180 samples) comparing pre- enrichment, enrichment and post- enrichment phases.

Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China.

Objective: We aim to investigate whether Coronavirus disease 2019 (COVID-19) worsens chronic hepatitis B virus(HBV)infection and explore the incidence of long COVID symptoms in patients with chronic hepatitis B virus infection.

Methods: Patients with chronic HBV infection and COVID-19 patients attending the hepatitis clinic or fever clinic were included in the study. Clinical manifestations of COVID-19 and information about long COVID were collected for all patients.

2024 Update of the RECOVER-Adult Long COVID Research Index.

Importance: Classification of persons with long COVID (LC) or post-COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate newly available data as the field rapidly evolves.

Objective: To update the 2023 research index for adults with LC using additional participant data from the Researching COVID to Enhance Recovery (RECOVER-Adult) study and an expanded symptom list based on input from patient communities.

Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.

Olfactory sensitivity to odorant molecules is a complex biological function influenced by both endogenous factors, such as genetic background and physiological state, and exogenous factors, such as environmental conditions. In animals, this vital ability is mediated by olfactory sensory neurons (OSNs), which are distributed across several specialized olfactory subsystems depending on the species. Using the phosphorylation of the ribosomal protein S6 (rpS6) in OSNs following sensory stimulation, we developed an ex vivo assay allowing the simultaneous conditioning and odorant stimulation of different mouse olfactory subsystems, including the main olfactory epithelium, the vomeronasal organ, and the Grueneberg ganglion.

Coffee Silverskin as a Potential Ingredient for Functional Foods: Recent Advances and a Case Study with Chocolate Cake.

Coffee silverskin (CS) is a by-product of the coffee roasting process that is known for its potential as a fiber source with antioxidant properties. Therefore, this study aimed to provide an overview of the latest research on CS as a potential ingredient for functional foods and to evaluate the effect of adding different amounts of CS on the functional and sensory attributes of chocolate cakes. The addition of CS increased the total dietary fiber content, antioxidant capacity and the contents of extractable and non-extractable phenolics in the cakes.

The Changes in Color and Image Parameters and Sensory Attributes of Freeze-Dried Clones and a Cultivar of Red-Fleshed Apples.

The target of breeding red-fleshed apples is to increase their potential health benefits related to red flesh coloration and consumer acceptance. The objective of this study was to determine the usefulness of four clones (90, 120, 156, and 158) of red-fleshed apples for freeze-drying compared to the cultivar 'Trinity'. Red-fleshed apples were dried in the form of slices using a laboratory freeze-dryer.

Changes in taste and odor sensitivities during repeated bicycle ergometer exercises.

Background: Effective nutritional support is essential for maintaining good performance during exercise. Taste and olfaction are key senses for food intake, and understanding how their sensitivities change during exercise is important for effective nutritional support. However, the effects of exercise on taste and odor sensitivities remain unclear.

Ambient air pollution undermines chemosensory sensitivity - a global perspective.

This study offers insights into the complex relationship between chemical species constituting air pollution and chemosensory function. We examined the relationship between chemical species known to contribute to air pollution and assault human health and chemosensory sensitivity. Chemosensory sensitivity data was retrieved from a large-scale study involving 711 urban-dwelling participants inhabiting 10 different regions of the globe.

Unsupervised discovery of family specific vocal usage in the Mongolian gerbil.

In nature, animal vocalizations can provide crucial information about identity, including kinship and hierarchy. However, lab-based vocal behavior is typically studied during brief interactions between animals with no prior social relationship, and under environmental conditions with limited ethological relevance. Here, we address this gap by establishing long-term acoustic recordings from Mongolian gerbil families, a core social group that uses an array of sonic and ultrasonic vocalizations.

Genome-wide Machine Learning Analysis of Anosmia and Ageusia with COVID-19.

The COVID-19 pandemic has caused substantial worldwide disruptions in health, economy, and society, manifesting symptoms such as loss of smell (anosmia) and loss of taste (ageusia), that can result in prolonged sensory impairment. Establishing the host genetic etiology of anosmia and ageusia in COVID-19 will aid in the overall understanding of the sensorineural aspect of the disease and contribute to possible treatments or cures. By using human genome sequencing data from the University of Iowa (UI) COVID-19 cohort (N=187) and the National Institute of Health All of Us (AoU) Research Program COVID-19 cohort (N=947), we investigated the genetics of anosmia and/or ageusia by employing feature selection techniques to construct a novel variant and gene prioritization pipeline, utilizing machine learning methods for the classification of patients.

Factors influencing the course of post-COVID-19-related symptoms: A bidirectional cohort study among employees in health and welfare services in Germany.

Objective: The aim of this study was to determine the prevalence and trajectory of persistent symptoms following COVID-19 and to investigate factors influencing these among employees in the health and welfare services in Germany.

Methods: This exploratory, mixed retro- and prospective cohort study using paper-and-pencil questionnaires was conducted among insured persons of the German Social Accident Insurance Institution for the health and welfare services with a SARS-CoV-2 infection in 2020. The baseline survey in February 2021 was succeeded by two follow-up surveys after 8 and 13 months.

Six-week engagement in after-school activities involving chemosensory education does not affect olfactory abilities and personal significance of olfaction in 9-11-year-olds: Preliminary evidence.

Chemosensory learning is a lifelong process of acquiring perceptual expertise and semantic knowledge about chemical stimuli within the everyday environment. In the research context, it is usually simulated using olfactory training, which typically involves repeated exposure to a set of odors over a period of time. Following olfactory training, enhanced olfactory performance has been observed in adults, and similar evidence is beginning to emerge in children.

[Developing a psychiatrist's flair: Lessons learned from two clinical cases of olfactory reference syndrome].

Olfaction is often neglected in psychiatric semiology, despite its clinical relevance and impact on social functioning. The olfactory reference syndrome (ORS), characterized by a false belief that a person emits a foul odor, causes severe distress and disrupts social functioning. This article aims to highlight the importance of olfaction in psychiatric semiology, with a focus on ORS.

Pharmacognostic Characterization of Primula macrophylla by Light Microscopy, Scanning Electron Microscopy and Analytical Techniques.

Traditional medicinal systems have extensively used Primula macrophylla (Primulaceae) to treat a variety conditions, including bronchitis, asthma, joint pain, fever and so forth. This study determines various pharmacognostic and phytochemical standards helpful to ensure the purity, safety, and efficacy of medicinal plant P. macrophylla.

What causes the urban river to look darker? An underestimated source of sulfide production in methanogenic metabolism.

The blackening and increased smelling of waterbodies steadily affect urban aquatic ecology. Sulfide is recognized as the key substance responsible for the darkening of urban rivers. However, the pathway of sulfide production and the underling microbial mechanisms in urban rivers are not fully understood.