5 results match your criteria: "Slovakia and Institute of Neuroimmunology[Affiliation]"
Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217.
Alzheimers Res Ther
November 2024
Axon Neuroscience R&D Services SE, Dvorakovo Nabr. 10, 81102, Bratislava, Slovakia.
Article Synopsis
- Tau pathology is closely linked to cognitive decline in Alzheimer's disease (AD), prompting the development of tau-targeting immunotherapies like AADvac1, aimed at halting disease progression.
- The ADAMANT clinical trial evaluated AADvac1 in a subgroup of mild AD participants with elevated plasma p-tau217 levels over 24 months, focusing on safety and several cognitive and biological outcome measures.
- Results showed AADvac1 was safe and well-tolerated, significantly reduced levels of plasma neurofilament light and glial fibrillary acidic protein, and had a favorable—though not statistically significant—impact on cognitive scores and brain tissue preservation in certain regions, particularly in older participants.
New approaches and omics tools for mining of vaccine candidates against vector-borne diseases.
Mol Biosyst
August 2016
ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. and Laboratory of Biomedical Microbiology and Immunology, Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Kosice, Slovakia and Institute of Neuroimmunology, Slovakia Academy of Sciences, Bratislava, Slovakia.
Article Synopsis
- Vector-borne diseases (VBDs) pose significant risks to human and animal health and impact livestock production, prompting a shift towards developing vaccines for sustainable control.
- Recent advancements in genomics and related technologies have led to innovative "third generation" vaccines that utilize methods like reverse vaccinology and systems biology, which speed up vaccine development and improve candidate discovery.
- The review focuses on these new generation vaccines for VBDs, particularly anti-tick vaccines aimed at reducing both vector populations and the pathogens they carry, while addressing the challenges faced during the vaccine development process.
Library-based display technologies: where do we stand?
Mol Biosyst
July 2016
ERA Chair FP7, Internal diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. and Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Kosice, Slovakia and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Over the past two decades, library-based display technologies have been staggeringly optimized since their appearance in order to mimic the process of natural molecular evolution. Display technologies are essential for the isolation of specific high-affinity binding molecules (proteins, polypeptides, nucleic acids and others) for diagnostic and therapeutic applications in cancer, infectious diseases, autoimmune, neurodegenerative, inflammatory pathologies etc. Applications extend to other fields such as antibody and enzyme engineering, cell-free protein synthesis and the discovery of protein-protein interactions.
View Article and Find Full Text PDFHigh-throughput proteomics and the fight against pathogens.
Mol Biosyst
July 2016
ERA Chair VetMedZg Project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. and Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Kosice, Slovakia and Institute of Neuroimmunology, Slovakia Academy of Sciences, Bratislava, Slovakia.
Pathogens pose a major threat to human and animal welfare. Understanding the interspecies host-pathogen protein-protein interactions could lead to the development of novel strategies to combat infectious diseases through the rapid development of new therapeutics. The first step in understanding the host-pathogen crosstalk is to identify interacting proteins in order to define crucial hot-spots in the host-pathogen interactome, such as the proposed pharmaceutical targets by means of high-throughput proteomic methodologies.
View Article and Find Full Text PDFOmics approaches to probe markers of disease resistance in animal sciences.
Mol Biosyst
June 2016
ERA Chair FP7, Internal Diseases, Faculty of Veterinary Medicine, Heizelova 55, 10000 Zagreb, Croatia. and Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, Slovakia and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Omics technologies have been developed in recent decades and used in different thematics. More advancements were done in human and plant thematics. Omics is the conjugation of different techniques, studying all biological molecules (DNA, RNA, proteins, metabolites, etc.
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