Two new species of Bryaxis Kugelann, 1794 (Coleoptera, Staphylinidae, Pselaphinae) from Montenegro.

Two new species of the genus Bryaxis Kugelann, 1794, Bryaxis duboki sp. nov. and Bryaxis biogradensis sp.

TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial.

Background: Patients with severe aortic stenosis present frequently (∼50%) with concomitant obstructive coronary artery disease. Current guidelines recommend combined surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG) as the preferred treatment. Transcatheter aortic valve implantation (TAVI) and fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) represent a valid treatment alternative.

Co(II), Cu(II), and Zn(II) thio-bis(benzimidazole) complexes induce apoptosis via mitochondrial pathway.

The copper(II), cobalt(II), and zinc(II) complexes with 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) and 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole (tebb), [Cu(tbb)Cl] (1), [Co(tbb)Cl] (2), [Zn(tbb)Cl] (3), [Cu(tebb)Cl(HO)]Cl (4), [Co(tebb)Cl]·nCHOH (5) and [Zn(tebb)Cl(HO)]Cl (6), have been prepared and evaluated for antiproliferative activity. The structure of (4) was proved by X-ray diffraction crystallography. The coordination compounds were tested for their cytotoxic activities in cancer cell lines in vitro.

Population comparison of facial soft tissue thickness.

The thickness of the face's soft tissue has been widely measured through different populations around the world. In this study, we gathered and compared multiple measurements including our study group. We set the variables and included studies in which only females with normal values of BMI, age from 18 to 30years old were studied, and we included research with more than 10 study participants.

International Society on Thrombosis and Haemostasis Clinical Practice Guideline for Treatment of Congenital Haemophilia-A Critical Appraisal.

Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing available evidence should consider this critical fact.

The role of financial inclusion and technological innovation in stimulating environmental sustainability in the European countries: A new perspective based on load capacity factor.

Given the alarming level of climate change, policymakers across the globe are seeking strategies to mitigate environmental pollution to achieve sustainable development. In this context, renewable energy and technological advancements have emerged as an effective way to lower pollution and attain sustainable development. This study evaluates the effect of financial inclusion, technological innovation, and renewable energy on the load capacity factor (LCF) in European countries from 2004 to 2018.

Gut microbiota and metabolic responses to a 12-week caloric restriction combined with strength and HIIT training in patients with obesity: a randomized trial.

Background: Nowadays, obesity has become a major health issue. In addition to negatively affecting body composition and metabolic health, recent evidence shows unfavorable shifts in gut microbiota in individuals with obesity. However, the effects of weight loss on gut microbes and metabolites remain controversial.

Establishment of recurrent exposures reference levels for repeated computed tomography examinations in adult patients on a nationwide level in Slovakia.

Introduction: The study aims were: (1) to assess the incidence in 1 year, the cumulative incidences and the period prevalence in 3/5 years of the condition of patients accruing cumulative effective dose (CED) ≥ 100 mSv in health care centres providing CT examinations in Slovakia; and (2) to quantify their variability among different centres, to test the feasibility of establishing recurrent exposure reference levels (RERL) on a nationwide level.

Materials And Methods: The data were tracked during five consecutive years using the CT dose index and dose-length-product along with the patient's ID. ED was calculated using conversion factors.

Prediction of potential occurrence of historical objects with defensive function in Slovakia using machine learning approach.

In this article, we aim at the prediction of possible locations of already defunct historical objects with a defensive function (HODFs) in Slovakia, which have not been found and documented so far, using three machine learning methods. Specifically, we used the support vector machine, k-nearest neighbors, and random forest algorithms, which were trained based on the following five factors influencing the possible occurrence of HODFs: elevation, distance from a river, distance from a settlement, lithological rock type, and type of representative geoecosystems. Training and testing datasets were based on a database of already documented 605 HODFs, which were divided into 70% of training samples and 30% of testing samples.

Epilepsy surgery in children with operculoinsular epilepsy: Results of a large unicentric cohort.

Objective: Epilepsy surgery in the operculoinsular cortex is challenging due to the difficult delineation of the epileptogenic zone and the high risk of postoperative deficits.

Methods: Pre- and postsurgical data from 30 pediatric patients who underwent operculoinsular cortex surgery at the Motol Epilepsy Center Prague from 2010 to 2022 were analyzed.

Results: Focal cortical dysplasia (FCD; n = 15, 50%) was the predominant cause of epilepsy, followed by epilepsy-associated tumors (n = 5, 17%) and tuberous sclerosis complex (n = 2, 7%).

Pain chronification risk assessment: advanced phenotyping and scoring for prediction and treatments tailored to individualized patient profile.

Unlabelled: Acute pain is a physiologic, protective life-important warning neurological signal indicating multi-level tissue modulations caused by a broad spectrum of health adverse events such as stress overload, mechanical trauma, ischemia-reperfusion, sterile and infection-triggered inflammation, single- and multi-organ damage, acute and chronic wounds, tissue remodeling and degeneration, amongst others. On the other hand, pain chronification results in a pathologic transformation from the protective pain signaling into persistent debilitative medical condition with severe consequences including but not restricted to phenotype-specific behavioral patterns, reduced quality of life, and cognitive and mood disorders. Who is predisposed to an increased vs.

Dataset on soil nematode abundance and composition from invaded and non-invaded grassland and forest ecosystems in Europe.

The dataset presents comprehensive information on soil nematode genera distribution in ecosystems across Slovakia, Poland, Lithuania, and Russia. Data were collected from invaded plots by invasive plants and non-invaded plots from grasslands, deciduous forests, and coniferous forest ecosystems in diverse geographical regions. Invasive plant species included in this dataset are and The soil properties such as pH, moisture content, carbon, and nitrogen levels were recorded, providing comprehensive information on soil conditions.

Inhibition of furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities.

Chimeric antigen receptor (CAR)-T-cell therapy has revolutionized cellular immunotherapy, demonstrating remarkable efficacy in hematological cancers. However, its application in solid tumors faces significant challenges, including limited T-cell infiltration and tumor-induced immunosuppression. Given the prominent role of macrophages in the tumor microenvironment, their phenotypic plasticity and inherent antitumor properties, such as phagocytosis, offer a promising avenue for therapeutic intervention.

Determination of melatonin by potentiometric stripping analysis using sensor based on boron-doped diamond electrodes.

A three-electrode screen-printed sensor with heavily doped microcrystalline boron-doped diamond electrodes grown by chemical vapor deposition on alumina substrates was used to determine the concentration of melatonin by constant current potentiometric stripping analysis. This paper provides a detailed examination of the irreversible oxidation behavior of melatonin by cyclic voltammetry at a boron-doped diamond electrode. The relationship between the current response and the square root of the scan rate confirmed a diffusion-controlled oxidation process.

Clinical Outcome Assessments for Spasticity: Review, Critique, and Recommendations.

Background: Spasticity is a common feature in patients with disruptions in corticospinal pathways. However, the term is used ambiguously. Here, spasticity is defined as enhanced velocity-dependent stretch reflexes and placed within the context of deforming spastic paresis encompassing other forms of muscle overactivity.

Prostate cancer in Slovakia: last decade overview.

Background: Prostate cancer is a significant health issue worldwide, with varying incidence and mortality rates across different regions. This study focuses on Slovakia, a country with an increasing trend in number of prostate cancer cases. The manuscript aims to provide a comprehensive overview of the burden of prostate cancer in Slovakia, encompassing epidemiological trends, economic impact, diagnostic approaches, and treatment modalities.