Solid-State Photoswitching of Hydrazones Based on Excited-State Intramolecular Proton Transfer.

The development of new photochromic systems is motivated by the possibility of controlling the properties and functions of materials with high spatial and temporal resolution in a reversible manner. While there are several classes of photoswitches operating in solution, the design of systems efficiently operating in the solid state remains highly challenging, mainly due to limitations related to confinement effects. Triaryl-hydrazones represent a relatively new subclass of bistable hydrazone photoswitches exhibiting efficient / photochromism in solution.

Potyvirus-Based Vectors for Heterologous Gene Expression in Plants.

Over the past two decades, plant viral vectors have emerged as a powerful tool for the production of recombinant proteins in plants. Among the different plant viruses engineered to carry foreign genes of interest in their genomes, potyviruses have gained attention due to their polyprotein expression strategy and broad host range. To date, at least eleven different species belonging to the genus have been used for heterologous gene expression in both their natural and experimental hosts.

Testing and Validation of the Vehicle Front Camera Verification Method Using External Stimulation.

The perception of the vehicle's environment is crucial for automated vehicles. Therefore, environmental sensors' reliability and correct functioning are becoming increasingly important. Current vehicle inspections and self-diagnostics must be adapted to ensure the correct functioning of environmental sensors throughout the vehicle's lifetime.

Signal Detection by Sensors and Determination of Friction Coefficient During Brake Lining Movement.

This article presents a laboratory device by which the course of two signals can be detected using two types of sensors-strain gauges and the DEWESoft DS-NET measuring apparatus. The values of the coefficient of friction of the brake lining when moving against the rotating shell of the brake drum were determined from the physical quantities sensed by tensometric sensors and transformed into electrical quantities. The friction coefficient of the brake lining on the circumference of the rotating brake disc shell can be calculated from the known values measured by the sensors, the design dimensions of the brake, and the revolutions of the rotating parts system.

Post-Processing Kalman Filter Application for Improving Cooperative Awareness Messages' Position Data Accuracy.

Cooperative intelligent transportation systems continuously send self-referenced data about their current status in the Cooperative Awareness Message (CAM). Each CAM contains the current position of the vehicle based on GPS accuracy, which can have inaccuracies in the meter range. However, a high accuracy of the position data is crucial for many applications, such as electronic toll collection or the reconstruction of traffic accidents.

Acoustic Wave Sensor Detection of an Ovarian Cancer Biomarker with Antifouling Surface Chemistry.

Ovarian cancer (OC) must be detected in its early stages when the mortality rate is the lowest to provide patients with the best chance of survival. Lysophosphatidic acid (LPA) is a critical OC biomarker since its levels are elevated across all stages and increase with disease progression. This paper presents an LPA assay based on a thickness shear mode acoustic sensor with dissipation monitoring that involves a new thiol molecule 3-(2-mercaptoethanoxy)propanoic acid (HS-MEG-COOH).

Small Gap Dynamics in High Mountain Central European Spruce Forests-The Role of Standing Dead Trees in Gap Formation.

Gap dynamics are driving many important processes in the development of temperate forest ecosystems. What remains largely unknown is how often the regeneration processes initialized by endogenous mortality of dominant and co-dominant canopy trees take place. We conducted a study in the high mountain forests of the Central Western Carpathians, naturally dominated by the Norway spruce.

Effects of Ketamine vs. Midazolam in Adolescent Treatment Resistant Depression.

Adolescent treatment resistant depression (TRD) is increasing in recent years. While ketamine showed rapid antidepressant effects in adult TRD studies, research on its effectiveness in adolescents is limited. This study examines the effects of intravenous ketamine vs.

Assessment of Surface Integrity in Precision Electrical Discharge Machining of HSS EN HS6-5-2C.

The integrity of the machined surface in precision wire electrical discharge machining (WEDM) of electrically conductive materials is one of the most important quality indicators. The integrity parameters of the machined surface are primarily monitored in terms of micro and macro geometry parameters. This paper presents the results obtained as a part of experimental research aimed at evaluating surface crack density (SCD) when machining EN HS6-5-2C using WEDM technology.

Sensory Quality, Volatile Compounds, and Physical Properties of Sheep's Milk Cheese with Herbs ( L.).

The aim of this study was to investigate the effect of the addition of wild garlic leaves on the sensory quality, volatiles, color, and texture of sheep milk soft rennet-curd cheese. The sensory evaluation of color, appearance, texture, odor, and taste was performed using a 5-point scale. The intensity of selected taste and odor discriminants was also assessed.

Wnt Signaling Inhibitors as Therapeutic Approach in Ischemic Heart Disease.

Wnt (wingless-type MMTV integration site family) signaling is an evolutionary conserved system highly active during embryogenesis, but in adult hearts has low activities under normal conditions. It is essential for a variety of physiological processes including stem cell regeneration, proliferation, migration, cell polarity, and morphogenesis, thereby ensuring homeostasis and regeneration of cardiac tissue. Its dysregulation and excessive activation during pathological conditions leads to morphological and functional changes in the heart resulting in impaired myocardial regeneration under pathological conditions such as myocardial infarction, heart failure, and coronary artery disease.

Durability of Wood-Cement Composites with Modified Composition by Limestone and Stabilised Spruce Chips.

Limestone (LS) and stabilised secondary spruce chips (SCs) utilisation in wood-cement composites is still an unexplored area. Therefore, the main objective of the research presented here is the assessment of the long-term behaviour of cement-bonded particleboards (CBPs) modified by LS and SCs. Cement (CE) was replaced by 10% of LS, and spruce chips by 7% of SCs.

Experimental Validation of Hydrogen Affinity as a Design Criterion for Alloys.

This study introduces an innovative approach to alloy design by experimentally validating the semi-empirical concept of Griessen and Driessen, which predicts the hydrogen affinity of solid solutions. The work focuses on designing and synthesizing four equiatomic high-entropy alloys (HEAs) with compositions tailored to exhibit highly endothermic enthalpies of solution and formation, resulting in resistance to hydrogen absorption. Unlike conventional studies that prioritize hydrogen storage capacity, this research uniquely targets alloys optimized for minimal hydrogen interaction, addressing critical needs in hydrogen storage and transportation technologies prone to hydrogen embrittlement.

A Novel Objective Method for Steel Degradation Rate Evaluation.

This article introduces a novel approach for assessing microstructure, particularly its degradation after extended operation. The authors focus on creep processes in power plant components, highlighting the importance of diagnostics in this field. This article emphasizes the value of combining traditional microstructure observation techniques with image analysis.

Sulforaphane and Benzyl Isothiocyanate Suppress Cell Proliferation and Trigger Cell Cycle Arrest, Autophagy, and Apoptosis in Human AML Cell Line.

Isothiocyanates (ITCs) are naturally occurring sulfur-containing compounds with diverse biological effects. This study investigated the effects of sulforaphane (SFN, an aliphatic ITC) and benzyl isothiocyanate (BITC, an aromatic ITC) on human acute myeloid leukemia SKM-1 cells, focusing on cell proliferation, cell death, and drug resistance. Both drug-sensitive SKM-1 cells and their drug-resistant SKM/VCR variant, which overexpresses the drug transporter P-glycoprotein, were used.

IL-6 Does Not Influence the Expression of and Other Mg-Homeostatic Factors.

Together with chronic inflammation, disturbed magnesium homeostasis is a factor accompanying chronic disease which thus contributes to a reduced quality of human life. In this study, our objective was to examine the possible IL-6-mediated chronic inflammation-dependent regulation of nine magnesiotropic genes encoding for constituents of magnesium homeostasis of the cell. We used three cell lines (HepG2, U-266, and PANC-1), all characterized by high expression of the gene and the presence of a membrane form of IL-6R capable of responding to human IL-6.

Synovial Fluid Markers and Extracellular Vesicles in Rheumatoid Arthritis.

In recent years, numerous potential prognostic biomarkers for rheumatoid arthritis (RA) have been investigated. Despite these advancements, clinical practice primarily relies on autoantibody tests-for rheumatoid factor (RF) and anti-citrullinated protein antibody (anti-CCP)-alongside inflammatory markers, such as the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Expanding the repertoire of diagnostic and therapeutic biomarkers is critical for improving clinical outcomes in RA.

The Effectiveness of Tonsillectomy in the Diagnostic Workup of Squamous Cell Carcinoma Unknown Primary in the Head and Neck Based on p16 Immunohistochemistry.

: Despite the distinct entity of both p16-positive and p16-negative squamous cell carcinoma unknown primary in the head and neck (HNSCCUP), the diagnostic workup did not differ. The aim of the study was to determine the effectiveness of palatine tonsillectomy in the identification of primary tumours in two groups of p16-positive and p16-negative HNSCCUP. : Patients with HNSCCUP managed in two tertiary care referral centres from 1 January 2014 to 31 December 2020 were analysed retrospectively.

Distal Triceps Tendon Rupture-First Retrospective Study in Central Europe.

This retrospective study is the only one in the last 10 years from central Europe and provides a current picture of prevalence, new diagnostic modalities, new methods of surgical treatment, and also offers new insights into post-operative care. Triceps tendon rupture is the least reported among all the tendon injuries in the literature. In general, effective treatments for tendon injuries are lacking because the understanding of tendon biology lags behind that of the other components of the musculoskeletal system.

Abstracts of the 16th European Congress of Paediatric and Adolescent Gynaecology .

PAG aims to foster a collaborative environment that bridges knowledge from various disciplines to ensure the highest quality of care for children and adolescents with gynaecological issues. The European Association of PAG and HellenicPAG, like all National PAG Societies, support research and education to advance new insights, improve health outcomes, enhance quality of life, and protect future fertility. Additionally, PAG promotes international cooperation by proposing guidelines for good clinical practice in terms of prevention, diagnosis, procedures, and treatment.

Morphology of the Human Pineal Gland Studied by Freeze-Fracturing in Scanning Electron Microscopy.

The human pineal gland is the largest producer of the hormone melatonin. Pineal acervuli (brain sand), calcified concretions in the pineal gland, have long been studied because of their association with ageing, melatonin production, and neurological disorders. The solid inorganic matter of the hydroxyapatite crystals often renders sample sectioning impossible, to the extent that the sections lose value.

Assessment of Facial Asymmetry in Slovak Patients with Positional Deformity.

Positional deformity (PD), also known as deformational plagiocephaly or non-synostosis, is a primary cause of abnormal head shape and asymmetry in infants. The most common type, occipital plagiocephaly, leads to flattening of one side of the back of the head or the entire head (positional brachycephaly). PD results from external forces on the growing skull, often due to childbirth and improper positioning during sleep.

The Toxic Legacy of Nickel Production and Its Impact on Environmental Health: A Case Study.

Nickel is a chemical element that occurs naturally in soil, water, air, plants, and therefore also in food and other living organisms. However, anthropogenic activities related to the production and processing of nickel can cause its increased concentration in the environment, which is a risk to wildlife and thus to human health. Nickel and its compounds are currently considered immunotoxic and carcinogenic agents that cause a number of health problems.

Microbial and Sensory Quality Changes in Broiler Chicken Breast Meat During Refrigerated Storage.

The aim of the study was to assess the bacterial flora of broiler chicken breast meat using the MALDI method, as well as its sensory evaluation while stored refrigerated at a stable temperature (0.5 °C+/-0.5 °C).

Problem of Existence of Joint Distribution on Quantum Logic.

This paper deals with the topics of modeling joint distributions on a generalized probability space. An algebraic structure known as quantum logic is taken as the basic model. There is a brief summary of some earlier published findings concerning a function -map, which is a mathematical tool suitable for constructing virtual joint probabilities of even non-compatible propositions.