Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis: A 48-Week, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial.

Objective: To explore the efficacy and safety of Juan Bi Pill (JBP) in treatment of active rheumatoid arthritis (RA).

Methods: From February 2017 to May 2018, 115 participants from 4 centers were randomly divided into JBP group (57 cases) and placebo group (58 cases) in a 1:1 ratio using a random number table method. Participants received a dose of JBP (4 g, twice a day, orally) combined with methotrexate (MTX, 10 mg per week) or placebo (4 g, twice a day, orally) combined with MTX for 12 weeks.

Longitudinal Associations Between Movement Behaviours and Development Among Infants Using Compositional Data Analysis.

Background: The study examined the longitudinal associations of sleep time, restrained time, back time and tummy time with development in a sample of infants using compositional data analysis.

Methods: Participants were a subsample of 93 parent-infant dyads from the Early Movers project in Edmonton, Canada. Parents completed a 3-day time-use diary at 2, 4 and 6 months of age.

Clinical study of two mandibular advancement devices in the treatment of Obstructive Sleep Apnea: a pilot randomized controlled trial.

Objective: A preliminary clinical evaluation of the efficacy, comfort, and adverse reactions of two mandibular advancement devices (MADs) in the treatment of Obstructive Sleep Apnea (OSA).

Methods: Forty patients with mild-to-severe OSA were recruited and randomly divided into two groups. They were treated with Shark-fin or Silensor MAD, respectively.

SLA-MLP: Enhancing Sleep Stage Analysis from EEG Signals Using Multilayer Perceptron Networks.

: Sleep stage analysis is considered to be the key factor for understanding and diagnosing various sleep disorders, as it provides insights into sleep quality and overall health. : Traditional methods of sleep stage classification, such as manual scoring and basic machine learning approaches, often suffer from limitations including subjective biases, limited scalability, and inadequate accuracy. Existing deep learning models have improved the accuracy of sleep stage classification but still face challenges such as overfitting, computational inefficiencies, and difficulties in handling imbalanced datasets.

Efficacy of Perineural Dexmedetomidine in Ultrasound-guided Interscalene Block on Rebound Pain after Shoulder Arthroscopy.

Objectives: This prospective, randomized, double-blind trial was performed to investigate the effect on rebound pain incidence of mixing dexmedetomidine (DEX) with local anesthetics in a combined injection interscalene block (ISB) during shoulder arthroscopy.

Methods: 47 patients were enrolled in this study. Patients were randomly assigned to 2 groups: Group DEX and Group Control received ultrasound-guided ISB using 12 mL of 0.

Health-related quality of life in 62 patients with diffuse low-grade glioma during a non-therapeutic and progression-free phase: a cross-sectional study.

Purpose: Few studies have evaluated the health-related quality of life (HRQoL) of patients with diffuse low-grade glioma (LGG) during a clinical and radiological monitoring period. We report a cross sectional cohort study of HRQoL in patients with LGG and compare the results with normative population data. We then explore factors associated with HRQoL.

Predicting Sleep Quality in Family Caregivers of Dementia Patients From Diverse Populations Using Wearable Sensor Data.

This study aimed to use wearable technology to predict the sleep quality of family caregivers of people with dementia among underrepresented groups. Caregivers of people with dementia often experience high levels of stress and poor sleep, and those from underrepresented communities face additional burdens, such as language barriers and cultural adaptation challenges. Participants, consisting of 29 dementia caregivers from underrepresented populations, wore smartwatches that tracked various physiological and behavioral markers, including stress level, heart rate, steps taken, sleep duration and stages, and overall daily wellness.

Nonmotor Manifestations of Idiopathic Parkinson's Disease and Its Correlation with the Severity and Duration of the Disease: A Cross-sectional Study.

Overview: Parkinson's disease (PD) is a neurodegenerative disorder that is common in individuals over the age of 50 years, affecting about 1% of the population. Nonmotor symptoms (NMS) are a common occurrence in PD, but they are often ignored by motor symptoms. Studies have shown that NMS in PD show a significant impact on quality of life.

Treatment effect and safety of seltorexant as monotherapy for patients with major depressive disorder: a randomized, placebo-controlled clinical trial.

The antidepressant efficacy and safety of seltorexant monotherapy in major depressive disorder (MDD) was investigated in a placebo-controlled, placebo lead-in, randomized, double-blind, phase 1b study. Participants were randomized to receive seltorexant (20 mg or 40 mg) or placebo. The treatment effect was assessed by changes in the Hamilton Rating Scale for Depression-17 item (HDRS) from treatment-period baseline to week 5 in lead-in placebo non-responders ("enriched" intent-to-treat analysis set).

Association between Obstructive Sleep Apnea and Age-related Macular Degeneration Development and Progression.

Objective: Evaluate the risk of age-related macular degeneration (AMD) development and progression in individuals with diagnosed obstructive sleep apnea (OSA).

Design: Retrospective cohort study.

Subjects: 60,652 and 1,173,723 individuals with OSA or not, respectively, were included in the study before propensity score matching (PSM).

Enhancing automatic sleep stage classification with cerebellar EEG and machine learning techniques.

Sleep disorders have become a significant health concern in modern society. To investigate and diagnose sleep disorders, sleep analysis has emerged as the primary research method. Conventional polysomnography primarily relies on cerebral electroencephalography (EEG) and electromyography (EMG) for sleep stage scoring, but manual scoring is time-consuming and subjective.

Factors influencing pregnant women's intention toward bed-sharing with infant in China: a cross-sectional study.

Bed-sharing can have a negative impact on infant sleep safety. In order to reduce the occurrence of bed-sharing with infants, it's necessary to shift the research lens from newborn parents to the antenatal stage before infant birth. Our study aimed to assess the attitudes, subjective norms, perceived behavioral control, and intentions of pregnant women about bed-sharing based on the theory of planned behavior (TPB).

Effect of perioperative dexmedetomidine on sleep quality in adult patients after noncardiac surgery: A systematic review and meta-analysis of randomized trials.

Background: Dexmedetomidine may improve sleep quality after surgery, but conflicting results also exist. Herein, we explored the effects of perioperative dexmedetomidine on postoperative sleep quality in adult patients.

Methods: In this systematic review and meta-analysis, randomized controlled trials investigating the effects of perioperative dexmedetomidine on sleep quality after noncardiac surgery were retrieved from Cochrane Library, PubMed, and EMBASE from inception to January 12, 2023, and updated on March 15, 2024.

Research on Sleep Staging Based on Support Vector Machine and Extreme Gradient Boosting Algorithm.

Purpose: To develop a sleep-staging algorithm based on support vector machine (SVM) and extreme gradient boosting model (XB Boost) and evaluate its performance.

Methods: In this study, data features were extracted based on physiological significance, feature dimension reduction was performed through appropriate methods, and XG Boost classifier and SVM were used for classification. One hundred and twenty training sets and 80 test sets were randomly composed of the first 200 groups of data from the SHH1 database.

Sleep Quality Improves Post Total Knee Arthroplasty: Addressing Early Disturbance and Risk Factors.

Objectives: Sleep is an important determinant of quality of life. Sleep disturbance is concomitant with end-stage knee osteoarthritis for which Total Knee Arthroplasty (TKA) is the most commonly done procedure. However, literature on this topic is lacking in terms of the impact of sleep quality on patient satisfaction after arthroplasty, especially the adverse associations of surgery on sleep quality.

Integration in Mixed Methods Research With an Exemplar Explanatory Sequential Study.

Background: Integration-a hallmark of mixed methods research (MMR)-is crucial throughout the entire research process. Despite its importance, integration remains an elusive concept often inadequately addressed by researchers, with many publications focusing solely on the final stages of data analysis and interpretation.

Objectives: The authors aim to synthesize methodologic discussions of the mixed method research integration process and provide an illustration of integration across all phases of an exemplar explanatory sequential study.

Cortical Functional Connectivity Changes in the Body-First and Brain-First Subtypes of Parkinson's Disease.

Background: Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body-first subtype, where synucleinopathy originates from the peripheral autonomic nervous system. Conversely, in the brain-first subtype, pathology would arise in the brain.