545 results match your criteria: "Skin Lightening and Depigmenting Agents"
Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota.
Molecules
November 2024
Givaudan Active Beauty, R&D, 31400 Toulouse, France.
(1) Background: Ultraviolet radiation takes part in photoaging and pigmentation disorders on skin. Epigallocatechin gallate (EGCG) is a well-known brightening and photoprotective compound but it faces limitations in terms of stability and solubility. (2) Methods: A more stable and water-soluble glucoside called EGCG-G1 was obtained by enzymatic glucosylation of EGCG.
View Article and Find Full Text PDFPickering emulsions embedded in Bletilla striata polysaccharide based nanogel for enhancing skin-whitening effect of essential oils.
Int J Pharm
December 2024
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China; State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang 330096, China. Electronic address:
To improve the retention time and skin-whitening efficacy of Atractylodes macrocephale essential oil (AMO), a novel Pickering emulsion based nanogel loaded with AMO (AMO-PEG) was successfully developed. This formulation employed nano-pearl powder (NPP) as the particle stabilizer for the Pickering emulsion and Bletilla striata polysaccharide (BSP) as the gel matrix. The pH, rheological properties, hardness, and elasticity of AMO-PEG were affected by the ratio of AMO-Pickering emulsion (AMO-PE) to BSP gel matrix.
View Article and Find Full Text PDFFunctional Properties and Components of Koenigia alpina Extract.
Skin Res Technol
October 2024
Department of Biohealth Engineering, College of Science and Convergence Technology, Seoul Women's University, Nowon-gu, Seoul, Republic of Korea.
Article Synopsis
- Koenigia alpina is a perennial herb studied for its potential use in cosmeceuticals, though its properties haven't been thoroughly examined until now.
- Researchers induced inflammation in cells and tested K. alpina extracts for their ability to scavenge free radicals, inhibit enzymes related to aging, and promote wound healing.
- Results showed that K. alpina extracts had strong antioxidant and anti-inflammatory properties, suggesting they could be effective in antiaging skincare products.
Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects.
Colloids Surf B Biointerfaces
January 2025
ShangYa (GuangZhou) Biogene Technology Co., Ltd, China. Electronic address:
Article Synopsis
- Collagen-based skincare products have limitations in effectiveness because collagen cannot easily penetrate the skin's deeper layers, the dermis.
- The study explored the use of supramolecular collagen nanoparticles, including lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5, which showed good stability and improved transdermal absorption by nearly 70%.
- Results over 28 days indicated significant skincare benefits, such as increased moisture, improved elasticity and firmness, reduced wrinkles, and a decrease in facial pigmentation, suggesting these nanoparticles are promising for enhancing cosmetic formulations.
In Vitro In Silico Screening Strategy and Mechanism of Novel Tyrosinase Inhibitory Peptides from Nacre of .
Mar Drugs
September 2024
Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Province Engineering Laboratory for Marine Biological Products, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Article Synopsis
- Traditional Chinese medicines have used pearl and nacre powders for skin whitening effects for thousands of years, and this research focuses on creating effective enzymatic hydrolysates from nacre powder using specific enzymes and high temperatures.* -
- A novel peptide, Tyr-Pro-Asn-Pro-Tyr (YPNPY), was identified as a potent tyrosinase inhibitor with an IC value of 0.545 ± 0.028 mM, demonstrating its ability to bind to the enzyme and reduce melanin production in B16F10 cells.* -
- The findings suggest that YPNPY could be beneficial in developing skin whitening products due to its dual action as a tyrosinase inhibitor and antioxidant, potentially being used in whitening foods
Nano-vesicular systems for melanocytes targeting and melasma treatment: In-vitro characterization, ex-vivo skin retention, and preliminary clinical appraisal.
Int J Pharm
November 2024
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Article Synopsis
- * Three types of nano-vesicular systems—liposomes, penetration enhancer vesicles (PEVs), and invasomes—were developed, showing effective sizes, stability, and prolonged release of alpha arbutin for up to 24 hours.
- * A clinical study indicated that using the alpha arbutin-loaded liposomes and PEVs resulted in significantly better outcomes for melasma patients compared to traditional treatments, highlighting their potential as superior delivery systems for skin care.
Understanding the motivations behind deliberate lightening of skin among burkinabe women through a socio-anthropological analysis.
Soc Sci Med
November 2024
University Daniel Ouezzin Coulibaly (Burkina Faso), Burkina Faso. Electronic address:
Deliberate lightening of skin among African women is a complex phenomenon that intersects with cultural identity, health, beauty, and societal influence. The scientific literature has scarcely explored a comprehensive approach by interviewing users of skin lightening products. This article aims to analyze, through a comprehensive approach, the motivations underlying the deliberate lightening of skin among Burkinabe women.
View Article and Find Full Text PDFExploration of Compounds with 2-Phenylbenzo[]oxazole Scaffold as Potential Skin-Lightening Agents through Inhibition of Melanin Biosynthesis and Tyrosinase Activity.
Molecules
September 2024
Department of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Article Synopsis
- * Resorcinol-containing compounds showed significantly better mushroom tyrosinase inhibition compared to kojic acid, with one compound achieving a remarkable IC value of 0.51 μM.
- * These compounds not only inhibited tyrosinase activity and melanin production effectively in cell tests but also demonstrated strong depigmentation in zebrafish larvae without causing toxicity, indicating their safety for use on skin.
Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation.
J Cosmet Dermatol
December 2024
Foshan Conney Allan Biotechnology Co. Ltd, Foshan, China.
Article Synopsis
- Solar lentigo is a common skin condition that can be effectively treated using a combination of traditional Chinese medicines and their active compounds.
- The study employed advanced techniques like liquid chromatography-mass spectrometry and network pharmacology to identify key compounds and assess their effects on pigmentation in both mice and humans.
- Results showed that the treatment significantly reduced UVB-induced pigmentation and improved skin health, confirming the potential of TCMM as a comprehensive treatment strategy.
Antioxidant and Skin-Whitening Efficacy of a Novel Decapeptide (DP, KGYSSYICDK) Derived from Fish By-Products.
Mar Drugs
August 2024
Department of Medical Laboratory Science, College of Health Science, Dankook University, Cheonan-si 31116, Chungcheongnam-do, Republic of Korea.
Article Synopsis
- The skin is susceptible to damage from UV rays and oxidative stress, which can result in aging and pigmentation issues; this study explores the potential of a decapeptide (DP) from marine fish by-products as a skin-whitening agent.
- DP showed strong antioxidant activity, outperforming Vitamin C in various tests, and demonstrated protective effects on HaCaT cells against hydrogen peroxide damage while also inhibiting melanin production in melanoma cells.
- The research indicates that DP interacts strongly with tyrosinase, an enzyme involved in melanin production, suggesting it has promising properties for skin whitening and warrants further studies to optimize its effectiveness.
Advancing Health Equity: Efforts to Expand Education on Skin Lightening Products.
Public Health Rep
July 2024
Office of Minority Health and Health Equity, Office of the Commissioner, US Food and Drug Administration, Silver Spring, MD, USA.
Efficacy, safety, tolerability and treatment durability of microneedling plus topical tranexamic acid in combination with topical modified Kligman lightening formula for melasma: A four-arm assessor and analyst blinded randomized controlled clinical trial.
J Cosmet Dermatol
November 2024
Department of Dermatology, Rasool Akram Medical Complex Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Background: The challenging management of melasma highlights the inadequacies of conventional therapies and their high risk of recurrence. Integrating microneedling for device-assisted drug delivery with tranexamic acid (TA), recognized for its melanin synthesis inhibition, presents a novel approach that warrants further investigation to fully assess its potential in enhancing melasma treatment efficacy.
Methods: Fifty moderate to severe melasma patients participated in this randomized outcome-assessor-blinded controlled trial.
Article Synopsis
- A patient with a decade-long history of blue-black skin lesions attributed to skin-lightening creams was diagnosed with exogenous ochronosis (EO), despite an inconclusive biopsy.
- EO is characterized by hyperpigmentation from hydroquinone products, commonly affecting Black populations due to widespread use.
- Accurate recognition of EO's clinical features by dermatologists is essential for early diagnosis and can prevent progression to more severe skin symptoms.
A Patient With Proteinuria, Myalgias, and Decreased Pigmentation of Facial Skin.
JAMA
July 2024
Department of Nephrology, The First People's Hospital of Yongkang, Affiliated to Hangzhou Medical College, Yongkang, China.
Rapid discovery of natural skin-lightening ingredients based on an integrated screening strategy based on molecular docking and zebrafish model.
J Cosmet Dermatol
November 2024
School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Science, Jinan, China.
Background: Natural herbs have been widely considered a reservoir for skin-lightening ingredients, but discovery of the effective ingredients from herbs remains a large challenge.
Aim: This research aimed to rapidly identify compounds with skin-lightening activity in Chinese herbs.
Methods: The structure information of herbal compounds was collected and selected from the open-source data.
Nanosystems with potential application as carriers for skin depigmenting actives.
Nanotechnology
July 2024
Federal University of Rio de Janeiro, Institute of Macromolecules, Center of Technology, Ilha do Fundão, Rio de Janeiro, Brazil.
Article Synopsis
- - Hyperpigmentation is a skin disorder caused by too much melanin, leading to various conditions like melasma and post-inflammatory hyperpigmentation.
- - Topical depigmenting agents are a less invasive treatment for hyperpigmentation than chemical peels or lasers, but they can cause side effects like redness and irritation; encapsulating these agents in nanosystems may help reduce these side effects.
- - This literature review assesses the advancements in nanosystems over the past 15 years, exploring how they can enhance the delivery of depigmenting agents in skincare products to better treat skin hyperchromias and improve patients' quality of life.
An Update on New and Existing Treatments for the Management of Melasma.
Am J Clin Dermatol
September 2024
Department of Dermatology, The Royal Children's Hospital, Melbourne, VIC, Australia.
Article Synopsis
- Melasma is a long-lasting skin condition that causes dark patches on the skin, affecting both the patient’s mental health and the doctor's treatment efforts.
- There are many treatment options being researched and combined due to the various causes of melasma, including new approaches like visible light protection and non-hydroquinone agents.
- Staying informed about the latest treatments for melasma is crucial yet difficult to ensure effective and comfortable solutions for patients.*
Worldwide internet trends in the public interest related to skin whitening and bleaching creams.
J Cosmet Laser Ther
August 2024
Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Article Synopsis
- Skin whitening, a common practice in Africa and Asia, involves using harmful substances like hydroquinone and mercury, which have been banned in several countries due to their side effects.
- A study utilized Google Trends over a 10-year period to analyze the popularity of skin whitening searches, revealing that interest increased globally, particularly in Sudan, Vietnam, and Sri Lanka.
- Despite the risks, searches for skin whitening creams, especially hydroquinone, are on the rise, highlighting the need for education on the dangers of these products, particularly in affected regions.
Establishment of an in vitro cell coculture model for investigating the whitening mechanism of Paeonia lactiflora Pall seeds oil.
J Cosmet Dermatol
September 2024
Huzhou Jiaheng Industrial Co., Ltd, Huzhou, China.
Article Synopsis
- A new coculture model of B16F10-HaCaT cells was developed to improve the reliability of in vitro tests for cosmetic active ingredients by mimicking human skin structure.
- The study focused on understanding how Paeonia lactiflora Pall seeds oil can inhibit melanin production and transfer, which is important for developing effective cosmetic whitening agents.
- Results showed that the oil did not affect cell growth but significantly reduced tyrosinase activity and melanin content, suggesting its potential as a whitening additive.
An update on the safety of hydroquinone.
Arch Dermatol Res
June 2024
Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
Article Synopsis
- Hydroquinone has been traditionally used to treat skin conditions like melasma, hyperpigmentation, and photoaging due to its effectiveness as a lightening agent.
- Recent concerns about its safety have led to a ban on over-the-counter products containing hydroquinone in the U.S.
- This paper presents an updated review of studies on the safety of hydroquinone from the last 15 years, considering new findings since earlier reviews.
Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells.
Ann Dermatol
June 2024
Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China.
Article Synopsis
- Oral tranexamic acid (TXA) is more effective than topical TXA for reducing hyperpigmentation in melasma patients, as shown in studies involving UVB-irradiated mouse models and cultured skin cells.
- The research demonstrated that TXA decreases melanin production by suppressing endothelin-1 (ET-1) levels in endothelial cells, which in turn reduces melanocyte growth.
- Overall, the findings suggest that systemic (oral) TXA treatment provides better skin lightening effects by targeting specific molecular mechanisms compared to topical application.
Components analysis of San-Bai decoction, and its pharmacodynamics and mechanism on preventing and treating melasma.
J Ethnopharmacol
October 2024
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Grand Health Research Institute of Hefei Comprehensive National Science Center, Anhui University of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modern Pharmaceutical Preparation, Anhui Provincial Department of Education, China; Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei, 230012, China; Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei, 230012, China. Electronic address:
Article Synopsis
- San-Bai Decoction (SBD) is a traditional remedy from the Ming Dynasty known for its skin-whitening abilities and health benefits, but its exact workings and active ingredients are still unclear.!* -
- This study aims to identify the active components of SBD and understand how it helps reduce melasma, using techniques like mass spectrometry and metabolic analysis on rats.!* -
- Researchers evaluated SBD's effectiveness against melasma by examining its impact on inflammation and oxidative stress, focusing on its influence on the PI3K/AKT signaling pathway.!*
Quantification of Arbutin and its degradation products, hydroquinone and p-Benzoquinone, in hyperpigmentation topical formulation: Effect of extraction procedure and interference assessment.
J Pharm Biomed Anal
August 2024
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
Article Synopsis
- Hydroquinone (HQ) is restricted in over-the-counter skincare, making Arbutin (AR) a popular alternative for treating hyperpigmentation, despite its potential to decompose into toxic byproducts when exposed to certain conditions.
- This study focuses on how different extraction procedures affect the conversion of AR to HQ and p-Benzoquinone (BZ), while assessing the kinetics of AR hydrolysis and the interference of AR and BZ in the identification of HQ using established USP methods.
- The research highlighted that AR's hydrolysis follows a zero-order kinetic profile, revealing its consistent degradation rate regardless of concentration, and confirmed that AR can interfere with UV-VIS spectrophotometry used for HQ measurement, which could lead to inaccurate
The whitening efficacy of a compound formula examined using an ultraviolet-induced skin melanization model.
J Cosmet Dermatol
August 2024
Center of Cosmetic Evaluation, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- In Eastern culture, women with darker skin face beauty standards that favor a fair complexion, leading to distress and a demand for whitening cosmetics.
- A study was conducted to evaluate the safety and efficacy of a compound formula called TEST, which includes ingredients like astaxanthin and nicotinamide, for skin whitening.
- Results showed that TEST was safe, improved skin tone significantly, and reduced the melanin index after treatment, suggesting it can be used in skin-whitening products.