8 results match your criteria: "Skin Care Research Institute[Affiliation]"
Pediatr Allergy Immunol
November 2023
Department of Clinical Epidemiology & Clinical Trial Unit, Children's Hospital of Fudan University & National Children Medical Center, Shanghai, China.
Background: Trajectories of stratum corneum (SC) lipid subclasses and their associations with infant atopic dermatitis (AD) are unclear. This study aimed to quantify the trajectories of 15 SC subclasses and carbon chain lengths and their associations with AD within 12 months.
Methods: In total, 213 newborns were enrolled at birth with nonlesional skin samples collected from the inner forearm at birth, 42 days, 3, 6, and 12 months, respectively.
Background: Skin barrier functions develop after birth and may be related to skin disorders in infants. We aimed to assess associations between dynamic trends of four skin barrier functional parameters in early life with infant atopic dermatitis (AD).
Methods: Based on the prospective cohort MKNFOAD (NCT02889081), we examined transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin pH, and sebum content at five anatomical sites (cheek, forehead, forearm, abdomen, and lower leg) in 418 term infants at birth, 42 days, and 6 months.
Photochem Photobiol
September 2020
Nutraceuticals Division, Otsu Skin Care Research Institute, Otsuka Pharmaceutical Co., Ltd., Otsu, Japan.
Infrared-A (IRA), which can penetrate deeply into the human skin, is a major component of solar radiation and is recognized to promote photoaging of human dermis. To our knowledge, however, the cellular and molecular consequences of human epidermis exposure to IRA have not been clarified. Thus, we investigated whether IRA inhibits the proliferation of normal human epidermal keratinocytes (NHEKs).
View Article and Find Full Text PDFAnn Dermatol
December 2019
Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Background: Vernix caseosa (VC), which is known as a unique human substance, is a biofilm that covers the skin of most human newborns. VC has many biological functions including anti-infective, skin cleansing and skin barrier repair.
Objective: In the study, we purpose to investigate the novel effect of lipids extracted from VC on the regulation of filaggrin (FLG) expression and anti-inflammation in normal human epidermal keratinocyte (NHEK) cells.
Atopic dermatitis (AD) is a chronic inflammatory skin disease that can cause skin barrier function damage. Although co-incubation with docosahexaenoic acid (DHA) exerts a positive effect on deficient skin models, no studies have investigated the effects of topical treatment with DHA in an inflammatory reconstructed human epidermis (RHE) model. The effects of DHA on monolayer normal human epidermal keratinocyte (NHEK) cells were evaluated using cell counting kit-8 (CCK-8), real-time quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay (ELISA).
View Article and Find Full Text PDFInt J Mol Med
August 2016
Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
Desi-type chickpeas, which have long been used as a natural treatment for diabetes, have been reported to lower visceral adiposity, dyslipidemia and insulin resistance induced by a chronic high-fat diet in rats. In this study, in order to examine the effects of chickpeas of this type in an in vitro system, we used the 3T3-L1 mouse cell line, a subclone of Swiss 3T3 cells, which can differentiate into cells with an adipocyte-like phenotype, and we used ethanol extracts of chickpeas (ECP) instead of chickpeas. Treatment of the 3T3-L1 cells with ECP led to a decrease in the lipid content in the cells.
View Article and Find Full Text PDFMol Cell Endocrinol
September 2015
Bioinformatics & Molecular Design Research Center, Yonsei Engineering Research Park, Yonsei University, Seodaemun-gu, Seoul 120-749, Republic of Korea; Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address:
Dehydroabietic acid (DAA) is a naturally occurring diterpene resin acid of confers, such as pinus species (P. densiflora, P. sylvestris) and grand fir (Abies grandis), and it induces various biological actions including antimicrobial, antiulcer, and cardiovascular activities.
View Article and Find Full Text PDFBr J Dermatol
September 2008
Skin Care Research Institute, Johnson & Johnson Consumer France SAS, 92787 Issy-Les-Moulineaux, France.
Background: Various physical, chemical and biological insults, including exposure to ultraviolet (UV) radiation, cause erythema and change in pigmentation in human skin. These reactions provide an important measure of the cutaneous response to the insult.
Objectives: To present a new implementation of a method for objective in vivo measurement of erythema and pigmentation.