7 results match your criteria: "Sir Peter MacCallum Department of Oncology University of Melbourne Parkville VIC Australia.[Affiliation]"
Objectives: Haematopoietic stem cell transplant (HCT) is a cellular therapy that, whilst curative for a child's underlying disease, carries significant risk of mortality, including because of pulmonary complications. The aims of this study were to describe the burden of pulmonary complications post-HCT in a cohort of Australian children and identify risk factors for the development of these complications.
Methods: Patients were identified from the HCT databases at two paediatric transplant centres in Australia.
It is important to identify a retained fecalith and remove that infective nidus to decrease the morbidity in patients undergoing laparoscopic appendectomy for perforated appendicitis.
View Article and Find Full Text PDFContext: Ductal adenocarcinoma (DAC) is relatively rare, but is nonetheless the second most common subtype of prostate cancer. First described in 1967, opinion is still divided regarding its biology, prognosis, and outcome.
Objectives: To systematically interrogate the literature to clarify the epidemiology, diagnosis, management, progression, and survival statistics of DAC.
Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer.
Clin Transl Immunology
September 2020
Sir Peter MacCallum Department of Oncology University of Melbourne Parkville VIC Australia.
Article Synopsis
- Loss of type I interferon (IFN) signaling in tumors is linked to faster metastatic progression, which is why researchers are exploring alternative intratumoral agents like TLR 7/8 agonist 3M-052 for treating triple-negative breast cancer (TNBC).
- This study found that 3M-052 not only reduces tumor growth but also enhances the immune response, particularly through the activation of T-cells and dendritic cells, ultimately leading to reduced metastasis to the lungs.
- The findings suggest that using TLR agonists in immunotherapy could be a promising strategy to activate the immune system in tumors and prevent future metastases in TNBC patients.
Objective: To describe the technical aspects and outcomes of robotic-assisted radical prostatectomy (RARP) following abandoned open radical prostatectomy (ORP).
Patients And Methods: A retrospective review was performed of patients who underwent RARP following abandonment of ORP between 2016 and 2020. RARP was undertaken by two highly experienced robotic surgeons.
Objectives: To determine the rate of morbidity and assess the oncological outcomes for the subinguinal orchidectomy technique.
Background: Radical inguinal orchiectomy is the definitive management for a testicular mass suspicious for malignancy. The standard approach involves the division of the spermatic cord at the internal inguinal ring.
Objectives: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achieved remarkable efficacy in patients with some haematological cancers. However, challenges remain in CAR T-cell treatment of solid tumours because of tumour-mediated immunosuppression.
Methods: We have demonstrated that CAR T-cell stimulation through T-cell receptors (TCRs) can generate durable responses against solid tumours in a variety of murine models.