3 results match your criteria: "Sir James Spence Institute for Child Health[Affiliation]"

Discordance for X-linked hypophosphataemic rickets in identical twin girls.

Horm Res

June 2009

Institute of Human Genetics, Centre for Life, Newcastle University, Sir James Spence Institute for Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Background: We report monozygotic twin girls with a family history consistent with X-linked hypophosphataemic rickets (XLH). One twin had a skeletal and biochemical phenotype consistent with XLH, whilst the second twin appeared normal. Complete non-penetrance in XLH has not been previously reported and our aim was to explore potential reasons for this.

View Article and Find Full Text PDF

Retraction of muscle afferents from the rat ventral horn during development.

Neuroreport

February 1999

Department of Child Health, Sir James Spence Institute for Child Health, Newcastle University, Newcastle upon Tyne, UK.

The postnatal reorganization of rat proprioreceptive muscle afferent spinal terminal fields was explored by labelling transganglionically afferents from extensor digitorum communis with cholera toxin B sub-unit at different ages. Immunocytochemistry revealed labelled afferents in all segments examined (C4-T2) as well as retrogradely labelled motoneurones (C5-T1). Dorsal horn innervation appeared similar at all ages, but there were striking changes in the ventral horn.

View Article and Find Full Text PDF