HClO-Activated Near-Infrared Chemiluminescent Probes with a Malononitrile Group for In-Vivo Imaging.

Chemiluminescence (CL) imaging has emerged as a powerful approach to molecular imaging that allows exceptional sensitivity with virtually no background interference because of its unique capacity to emit photons without an external excitation source. Despite its high potential, the application of this nascent technique faces challenges because the current chemiluminescent agents have limited reactive sites, require complex synthesis, are insufficiently bright, and lack near-infrared emission. Herein, a series of HClO-activated chemiluminescent probes that exhibit robust near-infrared emission are studied.

Stabilizing Electron Transport of 2D Materials.

2D materials are promising candidates for beyond-Si electronic devices. However, their stability is a key bottleneck in their industrial applications. The instability of 2D materials is mainly attributed to their intrinsic susceptibility to O and HO-particularly to reactive oxygen species (ROS), which have strong oxidizing properties.

Heterogeneity During the Formation of Waterborne Barrier Coating Revealed by Cryogenic Transmission Electron Microscopy.

Imaging the film formation process of waterborne barrier coatings in situ with nanoscopic resolution is very challenging, which limits the understanding of the underlying mechanisms and rational design of the materials. Here this challenge is tackled using in situ cryogenic transmission electron microscopy (cryoTEM) in combination with electron tomography (cryoET), which allows 3D imaging of the process with <1 nm resolution. By monitoring the film formation process of poly(ethylene-co-methacrylic acid) (EMAA) ionomer dispersion, onion-like nano-aggregates are captured.

Reductive coupling of azonaphthalenes for the synthesis of BINAMs a diboron-enabled [5,5]-sigmatropic rearrangement.

The [5,5]-sigmatropic rearrangement is a less-studied reaction and may be strategically utilized to devise unique synthetic processes. Herein, we document a diboron-enabled [5,5]-sigmatropic rearrangement for practical synthesis of BINAM derivatives. Mechanistically, a concerted activation of azonaphthalenes by diboron creates a unique ten-membered transition state, which subsequently triggers a [5,5]-sigmatropic rearrangement.

Linitis Plastica in a Patient With Previous Breast Cancer: Primary Gastric Cancer or Breast Cancer Metastases?

Background: Linitis plastica is a challenging diagnosis in the setting of a patient with previous breast cancer.

Case Presentation: We present a case of a 74-year-old Chinese Female with a history of breast cancer who presented with epigastric pain, nausea, early satiety, and weight loss of 5 kg in 3 months. Endoscopic diagnosis of linitis plastica was made, but subsequent management plans were dependent on accurate histological assessment in view of her oncological history.

Impact of tree growth form on temporal and spatial patterns of particulate matter with various particle sizes in urban street canyons.

Context: Trees play a vital role in reducing street-level particulate matter (PM) pollution in metropolitan areas. However, the optimal tree growth type for maximizing the retention of various sizes of PM remains uncertain.

Objectives: This study assessed the PM reduction capabilities of evergreen and deciduous broadleaf street trees, focusing on how leaf phenology influences the dispersion of pollutants across particle sizes.

Hsa_circRNA_100791 Modulates Trim13 Through Sponging miR-487b-5p to Facilitate Inflammation in Allergic Rhinitis.

Background: Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNA molecules in eukaryotes, involved in many essential biological processes. However, their role in allergic rhinitis (AR) has not been extensively studied.

Methods: The expression levels of hsa_circRNA_100791 were measured using qRT-PCR in peripheral blood mononuclear cells (PBMCs) and nasal mucosa from AR patients.

Rapid Gluten Allergen Detection Using an Integrated Photoimaging Assay and Ionic Liquid Extraction Sensor.

In recent years, food allergies and food sensitivities have remained critical public health problems that affect approximately 15% of the global population. Wheat is a major food source worldwide, but it is also a common food allergen. Celiac disease is chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals; it can be treated only through strict gluten avoidance.

In Silico Modeling and Characterization of Epstein-Barr Virus Latent Membrane Protein 1 Protein.

Latent membrane protein 1 (LMP1) plays a crucial role in Epstein-Barr virus (EBV)'s ability to establish latency and is involved in developing and progressing EBV-associated cancers. Additionally, EBV-infected cells affect the immune responses, making it challenging for the immune system to eliminate them. Due to the aforementioned reasons, it is crucial to understand the structural features of LMP1, which are essential for the development of novel cancer therapies that target its signaling pathways.

A virtual reality cognitive screening tool based on the six cognitive domains.

Introduction: Early detection of cognitive impairment enables interventions to slow cognitive decline. Existing neuropsychological paper-and-pencil tests may not adequately assess cognition in real-life environments. A fully-immersive and automated virtual reality (VR) system-Cognitive Assessment using VIrtual REality (CAVIRE)-was developed to assess all six cognitive domains.

Metal-based smart nanosystems in cancer immunotherapy.

Metals are an emerging topic in cancer immunotherapy that have shown great potential in modulating cancer immunity cycle and promoting antitumor immunity by activating the intrinsic immunostimulatory mechanisms which have been identified in recent years. The main challenge of metal-assisted immunotherapy lies in the fact that the free metals as ion forms are easily cleared during circulation, and even cause systemic metal toxicity due to the off-target effects. With the rapid development of nanomedicine, metal-based smart nanosystems (MSNs) with unique controllable structure become one of the most promising delivery carriers to solve the issue, owing to their various endogenous/external stimuli-responsiveness to release free metal ions for metalloimmunotherapy.

Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing.

Infected burn wounds are characterized by persistent drug-resistant bacterial infection coupled with an inflammatory response, impeding the wound-healing process. In this study, an intelligent nanoparticle system (CCM+TTD@ZIF-8 NPs) was prepared using curcumin (CCM), an aggregation-induced emission luminogens (TTD), and ZIF-8 for infection-induced wound healing. The CCM+TTD@ZIF-8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response-guided photodynamic therapy (PDT), and anti-inflammatory.

Motor competence of children in Singapore using Movement ABC-2 test.

Introduction: The Movement Assessment Battery for Children, 2nd Edition (MABC-2) test is a valuable tool for identifying motor delays in children globally. However, there has been a lack of data for children in Singapore.

Methods: This study compared 175 children in Singapore (SG) aged 3-6 years to MABC-2 data based on the United Kingdom (UK) population, using statistical tests to analyze age, country, and gender effects on motor competence.

A Unique Role of the Oncoplastic Breast Surgeon's Approach to an Inframammary Proliferating Trichilemmal Cyst: A Case Report.

Trichilemmal cysts, also known as pilar cysts, are commonly found on hair-bearing surfaces, such as the scalp or hairline. These are cysts that form from hair follicles and are benign. We describe an unusual case of a middle-aged lady presenting with a longstanding left-sided inframammary mass that had started growing more in the last year prior to the presentation.

Diabetic retinopathy: A review on its pathophysiology and novel treatment modalities.

Diabetes mellitus (DM) is a chronic metabolic non-communicable disease with the ability to cause serious microvascular and macrovascular complications throughout the body, including in the eye. Diabetic retinopathy (DR), present in one-third of patients with diabetes, is a vision-threatening complication caused by uncontrolled diabetes, which greatly affects the retinal blood vessels and the light-sensitive inner retina, eventually leading to blindness. Several epidemiological studies elucidate that DR can vary by age of onset, duration, types of diabetes, and ethnicity.

Examining Women's support for birth encouragement policies in China: an extension of the influence of presumed media influence model.

This study employs the influence of the presumed media influence (IPMI) model to explore how media messages and interpersonal communication indirectly affect Chinese women's support for birth encouragement policies. Surveying 616 Chinese women of reproductive age, this study finds that exposure to media messages regarding childbirth benefits and interpersonal communication are positively correlated with the presumed influence of such media messages on others. Presumed media influence on others is further positively associated with perceived personal norms and social norms regarding support for birth encouragement policies.

Assessing the influence of latency variability on EEG classifiers - a case study of face repetition priming.

Unlabelled: Data-driven strategies have been widely used to distinguish experimental effects on single-trial EEG signals. However, how latency variability, such as within-condition jitter or latency shifts between conditions, affects the performance of EEG classifiers has not been well investigated. Without explicitly considering and disentangling such attributes of single trials, neural network-based classifiers have limitations in measuring their contributions.

Navigating COVID-19 Surges: A Case Study of a Hospital-at-Home Implementation.

This study documents the experience of implementing an adaptation of the Hospital-at-Home (HaH) model to alleviate the constraints in available hospital beds and manpower amid a surge in infection rates in Singapore during the Omicron and XBB COVID waves, addressing challenges and proposing insights for scalable implementation. HaH substitutes inpatient hospitalizations by leveraging existing community healthcare services and remote healthcare technologies. This HaH adaptation was designed to be activated in during surges and deactivated when bed and manpower demands stabilize, making it less intensive on hospital resources.

Exploring the Feasibility of a Caregiver Burden-Mastery Hybrid Assessment Tool With Decision Matrix in a Memory Clinic: A Multimethod Study.

Introduction: Family members caring for a person living with dementia (PWD) can experience caregiver burden, leading to psychological distress if unmanaged. It's essential for healthcare professionals, especially nurses to identify caregivers at risk of stress and depression, triggering prompt management during their contact with caregivers of PWD. The study team developed an evidence-based caregiver burden-mastery hybrid assessment and intervention decision matrix (CHAT-MI) for caregivers of PWD and examined its feasibility of use.

Investigating the pathogenicity of the recessive p.A251T variant in monogenic diabetes using iPSC-derived beta-like cells.

Monogenic diabetes, formerly called Maturity-Onset Diabetes of the Young (MODY), involves single-gene mutations, typically with dominant inheritance, and has been associated with variants in 14 genes. Among these, mutations are the most common, and their diagnosis allows the use of alternative therapies, including sulfonylureas. In an earlier study, we described a variant displaying recessive transmission, p.

COMPARING DETECTIONS OF AEDES AEGYPTI FEMALES USING THREE TYPES OF AUTOCIDAL GRAVID TRAPS.

We compared the number of Aedes aegypti females per trap and the number of detections of this mosquito species per week during 8 wk in 3 types of autocidal gravid traps, the Centers for Disease Control and Prevention (CDC) Autocidal Gravid Ovitrap (AGO), Biogents Gravid Aedes Trap (GAT), and Singapore Gravitrap (SGT), in central Puerto Rico. These traps use the same principles for attracting gravid Ae. aegypti females as traditional ovitraps, such as dark colors, standing water, and decomposing plant materials.

Trifluoroacetic Acid as a Molecular Probe for the Dense Phase in Liquid-Liquid Phase-Separating Peptide Systems.

Although trifluoroacetic acid (TFA) is not typically considered a Hofmeister reagent, it has been demonstrated to modulate biocoacervation. We show that TFA can be employed to probe specific interactions in coacervating bioinspired peptide phenylalanine (Phe) F-labeled at a single site, altering its liquid-liquid phase separation (LLPS) behavior. Solid-state nuclear magnetic resonance (NMR) spectroscopy revealed two dynamically distinct binding modes of TFA with Phe, resulting in a structured, dipolar-ordered complex and a more dynamic complex, highlighting the proximity between TFA and Phe.

The Effects of Universal Educational Interventions in Improving Mental Health Literacy, Depression, and Anxiety Among Adolescents: A Systematic Review and Meta-Analysis.

Adolescents are susceptible to developing depression and anxiety, and educational interventions could improve their mental well-being. This systematic review aimed to evaluate the effectiveness of universal educational prevention interventions in improving mental health literacy, depression, and anxiety among adolescents. Eight electronic databases were searched until June 2024: Cochrane Library, PubMed, EMBASE, CINAHL, PsycINFO, Scopus, Web of Science, ProQuest Dissertations, and Theses Global.