Characteristics and Outcomes of mHealth Interventions in Psychosis: Systematic Mapping Review.

Background: Mobile health (mHealth) interventions have gained popularity in augmenting psychiatric care for adults with psychosis. Interest has grown in leveraging mHealth to empower individuals living with severe mental illness and extend continuity of care beyond the hospital to the community. However, reported outcomes have been mixed, likely attributed in part to the intervention and adopted outcomes, which affected between-study comparisons.

Perovskite CsCuClxBr3- x Microcrystals: Band Structure, Photochemical Stability, and Photocatalytic Properties.

Although Pb-based metal halide perovskites (MHPs) have excellent photoelectric characteristics, their toxicity remains a limiting factor for their widespread application. In the paper, a series of CsCuClxBr3-x (x = 1, 2, 3) MHP microcrystals were developed and their hydrogen evolution performance in ethanol and HX (X = Cl, Br) was also studied. Among them, CsCuCl3 microcrystals exhibit high hydrogen evolution performance in both HX and ethanol, attributed to their longest average lifetime and suitable band structure.

Foxing of Watercolor Paper and Environmental Control as Preventive Actions.

In Singapore's hot and humid climate, watercolor papers are particularly prone to a paper oxidation issue known as foxing, which refers to the discoloration forming yellowish-brown stains on paper, changing the visual outcome of the watercolor artworks. This research investigates two most popular types of watercolor paper, made from 100% cotton and cotton-wood-pulp mixture. Foxing was generally categorized into two types: biotic and abiotic foxing caused by fungi activities and the presence of metallic contaminants catalytic fungi growth.

Topological Disclination States and Charge Fractionalization in a Non-Hermitian Lattice.

We show that a non-Hermitian lattice with a disclination can host topological disclination states that are induced by on-site gain and loss. The disclination states are inherently non-Hermitian as they do not exist in the limit of zero gain or loss. They arise from charge fractionalization in the non-Hermitian lattice, which we establish using non-Hermitian Wilson loops calculated with biorthogonal products.

Observation of Intricate Chiral Optical Force in a Spin-Curl Light Field.

Harnessing chiral optical forces facilitates numerous applications in enantioselective sorting and sensing. To date, significant challenges persist in substantiating the holistic complex theorem of these forces as experimental demonstrations employ common light waves (e.g.

A Self-Reinforced "Microglia Energy Modulator" for Synergistic Amyloid-β Clearance in Alzheimer's Disease Model.

Microglial phagocytosis is a highly energy-consuming process that plays critical roles in clearing neurotoxic amyloid-β (Aβ) in Alzheimer's disease (AD). However, microglial metabolism is defective overall in AD, thereby undermining microglial phagocytic functions. Herein, we repurpose the existing antineoplastic drug lonidamine (LND) conjugated with hollow mesoporous Prussian blue (HMPB) as a "microglial energy modulator" (termed LND@HMPB-T7) for safe and synergistic Aβ clearance.

Precise Supramolecular Nanoarchitectonics for Simultaneous Enhanced Photoluminescence and Photocatalysis in a Co-assembly by a Biomimetic Isolation-Conduction Strategy.

Limited by the two mutually exclusive physicochemical processes of separation and recombination of photogenerated carriers, achieving photoluminescence and photocatalysis simultaneously is extremely challenging but essential for ever-growing complex issues and specialized scenarios. Here we proposed a biomimetic isolation-conduction strategy induced by an arene-perfluoroarene (A-P) interaction for enabling photoluminescence and photocatalytic hydrogen evolution reaction (HER) activity in the co-assembly of aromatic monomers and octafluoronapthalene (OFN). Inspired by the isolation-conduction effect of periodic isolation of myelin sheaths on the axons of vertebrate nerve fibers by node of Ranvier, we use OFN as a molecular isolator embedded in the aromatic monomers array to block the singlet-to-triplet pathway, while the enlarged intermolecular dipoles resulting from the A-P interactions facilitate the conduction of photogenerated carriers in the isolated regions.

Ion Hydration Enables Generality in Asymmetric Catalysis: Desymmetrization to P-Stereogenic Triarylphosphine Derivatives.

Asymmetric synthesis relies on seamless transmission of stereochemical information from a chiral reagent/catalyst to a prochiral substrate. The disruption by substrates' structural changes presents a hurdle in innovating generality-oriented asymmetric catalysis. Here, we report a strategy for substrate adaptability by exploiting a fundamental physicochemical phenomenon-ion hydration, in developing remote desymmetrization to access P-stereogenic triarylphosphine oxides and sulfides.

Piezoelectric Activation of Peroxymonosulfate by CoMnO for Highly Efficient Tetracycline Degradation.

Advanced oxidation processes employing peroxymonosulfate (PMS) show significant promise for wastewater treatment. However, PMS activation typically relies on energy- and chemically intensive techniques due to its relatively low reactivity. Hence, the exploration of novel and energy-efficient approaches, such as the piezoelectric effect, for PMS activation is of paramount importance.

A Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template.

Third-degree burns result in extensive damage to the skin's epidermal and dermal layers, with limited treatment options available. Currently, xenogeneic collagen-based skin grafts are used as scaffolds to integrate into the wound bed and provide a template for neodermis formation. Existing commercial products like Integra dermal templates rely on a time-consuming and variable dehydrothermal (DHT) crosslinking process.

STING-Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy.

The unprecedented success of mRNA vaccines against COVID-19 has inspired scientists to develop mRNA vaccines for cancer immunotherapy. However, using nucleoside modified mRNA as vaccine, though evading innate immune toxicity, diminishes its therapeutic efficacy for cancers. Here, we report a polyvalent stimulator of interferon genes (STING) activating polymer (termed as PD) to bolster the immunogenicity of mRNA vaccine.

HClO-Activated Near-Infrared Chemiluminescent Probes with a Malononitrile Group for In-Vivo Imaging.

Chemiluminescence (CL) imaging has emerged as a powerful approach to molecular imaging that allows exceptional sensitivity with virtually no background interference because of its unique capacity to emit photons without an external excitation source. Despite its high potential, the application of this nascent technique faces challenges because the current chemiluminescent agents have limited reactive sites, require complex synthesis, are insufficiently bright, and lack near-infrared emission. Herein, a series of HClO-activated chemiluminescent probes that exhibit robust near-infrared emission are studied.

Stabilizing Electron Transport of 2D Materials.

2D materials are promising candidates for beyond-Si electronic devices. However, their stability is a key bottleneck in their industrial applications. The instability of 2D materials is mainly attributed to their intrinsic susceptibility to O and HO-particularly to reactive oxygen species (ROS), which have strong oxidizing properties.

Heterogeneity During the Formation of Waterborne Barrier Coating Revealed by Cryogenic Transmission Electron Microscopy.

Imaging the film formation process of waterborne barrier coatings in situ with nanoscopic resolution is very challenging, which limits the understanding of the underlying mechanisms and rational design of the materials. Here this challenge is tackled using in situ cryogenic transmission electron microscopy (cryoTEM) in combination with electron tomography (cryoET), which allows 3D imaging of the process with <1 nm resolution. By monitoring the film formation process of poly(ethylene-co-methacrylic acid) (EMAA) ionomer dispersion, onion-like nano-aggregates are captured.

Reductive coupling of azonaphthalenes for the synthesis of BINAMs a diboron-enabled [5,5]-sigmatropic rearrangement.

The [5,5]-sigmatropic rearrangement is a less-studied reaction and may be strategically utilized to devise unique synthetic processes. Herein, we document a diboron-enabled [5,5]-sigmatropic rearrangement for practical synthesis of BINAM derivatives. Mechanistically, a concerted activation of azonaphthalenes by diboron creates a unique ten-membered transition state, which subsequently triggers a [5,5]-sigmatropic rearrangement.

Linitis Plastica in a Patient With Previous Breast Cancer: Primary Gastric Cancer or Breast Cancer Metastases?

Background: Linitis plastica is a challenging diagnosis in the setting of a patient with previous breast cancer.

Case Presentation: We present a case of a 74-year-old Chinese Female with a history of breast cancer who presented with epigastric pain, nausea, early satiety, and weight loss of 5 kg in 3 months. Endoscopic diagnosis of linitis plastica was made, but subsequent management plans were dependent on accurate histological assessment in view of her oncological history.

Impact of tree growth form on temporal and spatial patterns of particulate matter with various particle sizes in urban street canyons.

Context: Trees play a vital role in reducing street-level particulate matter (PM) pollution in metropolitan areas. However, the optimal tree growth type for maximizing the retention of various sizes of PM remains uncertain.

Objectives: This study assessed the PM reduction capabilities of evergreen and deciduous broadleaf street trees, focusing on how leaf phenology influences the dispersion of pollutants across particle sizes.

Hsa_circRNA_100791 Modulates Trim13 Through Sponging miR-487b-5p to Facilitate Inflammation in Allergic Rhinitis.

Background: Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNA molecules in eukaryotes, involved in many essential biological processes. However, their role in allergic rhinitis (AR) has not been extensively studied.

Methods: The expression levels of hsa_circRNA_100791 were measured using qRT-PCR in peripheral blood mononuclear cells (PBMCs) and nasal mucosa from AR patients.

Rapid Gluten Allergen Detection Using an Integrated Photoimaging Assay and Ionic Liquid Extraction Sensor.

In recent years, food allergies and food sensitivities have remained critical public health problems that affect approximately 15% of the global population. Wheat is a major food source worldwide, but it is also a common food allergen. Celiac disease is chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals; it can be treated only through strict gluten avoidance.

In Silico Modeling and Characterization of Epstein-Barr Virus Latent Membrane Protein 1 Protein.

Latent membrane protein 1 (LMP1) plays a crucial role in Epstein-Barr virus (EBV)'s ability to establish latency and is involved in developing and progressing EBV-associated cancers. Additionally, EBV-infected cells affect the immune responses, making it challenging for the immune system to eliminate them. Due to the aforementioned reasons, it is crucial to understand the structural features of LMP1, which are essential for the development of novel cancer therapies that target its signaling pathways.

A virtual reality cognitive screening tool based on the six cognitive domains.

Introduction: Early detection of cognitive impairment enables interventions to slow cognitive decline. Existing neuropsychological paper-and-pencil tests may not adequately assess cognition in real-life environments. A fully-immersive and automated virtual reality (VR) system-Cognitive Assessment using VIrtual REality (CAVIRE)-was developed to assess all six cognitive domains.

Metal-based smart nanosystems in cancer immunotherapy.

Metals are an emerging topic in cancer immunotherapy that have shown great potential in modulating cancer immunity cycle and promoting antitumor immunity by activating the intrinsic immunostimulatory mechanisms which have been identified in recent years. The main challenge of metal-assisted immunotherapy lies in the fact that the free metals as ion forms are easily cleared during circulation, and even cause systemic metal toxicity due to the off-target effects. With the rapid development of nanomedicine, metal-based smart nanosystems (MSNs) with unique controllable structure become one of the most promising delivery carriers to solve the issue, owing to their various endogenous/external stimuli-responsiveness to release free metal ions for metalloimmunotherapy.

Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing.

Infected burn wounds are characterized by persistent drug-resistant bacterial infection coupled with an inflammatory response, impeding the wound-healing process. In this study, an intelligent nanoparticle system (CCM+TTD@ZIF-8 NPs) was prepared using curcumin (CCM), an aggregation-induced emission luminogens (TTD), and ZIF-8 for infection-induced wound healing. The CCM+TTD@ZIF-8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response-guided photodynamic therapy (PDT), and anti-inflammatory.