160,147 results match your criteria: "Singapore; KK Women's and Children's Hospital[Affiliation]"

Article Synopsis
  • Soft robotics is being explored for rehabilitation, offering potential benefits for individuals recovering upper limb motor function after injuries, with an emphasis on increased safety and comfort compared to traditional rigid robotics.
  • The article reviews clinical evidence from 37 studies on 13 different soft upper limb devices used in both clinical and home environments, assessing their effectiveness and user experience.
  • It aims to guide future developments in soft robotic rehabilitation by providing recommendations for design and application, highlighting the importance of understanding user needs and clinical outcomes.
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Monolayer transition metal dichalcogenides are promising materials that not only are atomically thin but also have direct bandgaps, making them highly regarded in optics and optoelectronics. However, their photoluminescence exhibits almost random polarization at room temperature. The emission is also omnidirectional and weak due to the low quantum yield.

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Context: TIO, a paraneoplastic disorder characterised by renal phosphate wasting, is cured by surgical removal of the culprit tumour. Despite correct localization, some remain refractory to intervention, resulting in substantial long-term medical complications.

Aim: We aim to identify risk factors associated with a refractory outcome.

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Transmembrane signaling receptors, such as integrins, organize as nanoclusters that provide several advantages, including increasing avidity, sensitivity (increasing the signal-to-noise ratio), and robustness (signaling threshold) of the signal in contrast to signaling by single receptors. Furthermore, compared to large micron-sized clusters, nanoclusters offer the advantage of rapid turnover for the disassembly of the signal. However, whether nanoclusters function as signaling hubs remains poorly understood.

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Objectives: Health technology assessment (HTA) guidelines are intended to support the successful implementation of HTA by enhancing consistency and transparency in concepts, methods, processes, and use, thereby enhancing the legitimacy of the decision-making process. This report lays out good practices and practical recommendations for developing or updating HTA guidelines to ensure successful implementation.

Methods: The task force was established in 2022 and comprised experts and academics from various geographical regions, each with substantial experience in developing HTA guidelines for national health policy making.

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Pain Management in Brugada Syndrome: A Case Report and Review.

A A Pract

January 2025

Division of Anaesthesiology and Perioperative Medicine, Department of Pain Medicine, Singapore General Hospital, Singapore.

Article Synopsis
  • Brugada syndrome is a rare condition that elevates the risk of serious heart arrhythmias, with limited guidance on pain management for these patients.
  • A case study of a young woman with the syndrome highlights the use of ropivacaine peripheral nerve infusion and intravenous ketamine for managing her acute-on-chronic pain in the left upper limb.
  • The approach included a multimodal analgesia strategy with neuropathic agents and opioids, aiming to improve safe pain management practices for those with Brugada syndrome.
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Article Synopsis
  • Marine plastispheres are dynamic microhabitats where microorganisms thrive on plastic debris, but their initial formation and interactions are not well understood.
  • This study used metaproteomic and metagenomic techniques to investigate the microbial diversity and biofilm development on low-density polyethylene (LDPE) over 3 and 7 days, identifying key organisms like Pseudomonas and Marinomonas.
  • Findings revealed that Pseudomonas dominated early, while Marinomonas and other genera became more prominent later, showcasing various metabolic pathways and competitive advantages that enhance our understanding of plastisphere ecology and its biotechnological potential.
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As one of the typical applications of metamaterials, the invisibility cloak has raised vast research interests. After many years' research efforts, the invisibility cloak has extended its applicability from optics and acoustics to electrostatics and thermal diffusion. One scientific challenge that has significantly restricted the practical application of the invisibility cloak is the strong background dependence, that is, all passive cloaking devices realized thus far are unable to resist variation in the background refractive index.

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Article Synopsis
  • Vedolizumab is an advanced treatment option for ulcerative colitis (UC) that can be effective but can lead to a loss of response over time, prompting the need to identify predictive factors for maintaining remission.
  • Researchers used logistic regression on participants from a study to create a VIEWS scoring system that assesses the likelihood of continuing remission after two years.
  • The study found that factors like gender, treatment history, and baseline health status were significant predictors, with the VIEWS score showing strong accuracy in predicting remission outcomes in two different patient cohorts.
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Objective: Identification of patients with head-and-neck malignancies who are especially vulnerable to malnutrition is critical for optimizing outcomes. The objectives are; to correlate Bioelectrical-impendence-analysis (BIA) parameters with Subjective-Global-Assessment (SGA) scores, and determine the association of BIA parameters with common perioperative complications in patients undergoing head-and-neck surgery.

Study Design: Patients underwent formal SGA scoring and BIA preoperatively in a multidisciplinary allied health clinic.

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A perspective on field-effect in energy and environmental catalysis.

Chem Sci

December 2024

Hunan Joint International Research Center for Carbon Dioxide Resource Utilization, State Key Laboratory of Powder Metallurgy, School of Physics, Central South University Changsha 410083 P. R. China

The development of catalytic technologies for sustainable energy conversion is a critical step toward addressing fossil fuel depletion and associated environmental challenges. High-efficiency catalysts are fundamental to advancing these technologies. Recently, field-effect facilitated catalytic processes have emerged as a promising approach in energy and environmental applications, including water splitting, CO reduction, nitrogen reduction, organic electrosynthesis, and biomass recycling.

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Consensus on the lung cancer management after third-generation EGFR-TKI resistance.

Lancet Reg Health West Pac

December 2024

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Article Synopsis
  • Lung cancer is the most common type of cancer in the Asia-Pacific region, with non-small cell lung cancer (NSCLC) making up about 85% of cases, and a significant mutation rate of 40-60% in Asian patients with lung adenocarcinoma.
  • Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) have improved treatment for NSCLC with mutations, but managing resistance to these drugs is still a major issue with no standardized guidelines.
  • A set of recommendations has been developed, integrating international guidelines and regional clinical experiences, to help healthcare providers classify resistance, conduct clinical testing, and devise treatment strategies for patients struggling with resistance to third-generation EGFR-TKIs.
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Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature.

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Article Synopsis
  • The generation of specific molecules is important in fields like biology and drug discovery, but existing models struggle with complex customization based on detailed language.
  • TextSMOG is a new method that combines language and diffusion models to allow for text-guided small molecule generation, enhancing stability and diversity.
  • Experimental results demonstrate that TextSMOG effectively uses textual descriptions to generate 3D molecular structures tailored to complex requests.
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Medical applications and prospects of polylactic acid materials.

iScience

December 2024

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.

Article Synopsis
  • Polylactic acid (PLA) is an environmentally friendly polymer that biodegrades and is made from renewable resources, making it a strong alternative to traditional plastics.
  • PLA is biocompatible and non-toxic, which improves safety in medical applications by minimizing tissue reactions and eliminating the need for additional surgeries due to its natural breakdown.
  • Recent advancements in nanotechnology and 3D printing have enhanced PLA’s structural and biological properties, expanding its use in drug delivery systems, orthopedic treatments, tissue engineering, and medical devices.
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Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.

Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).

Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions.

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Use of Complementary and Integrative Medicine Among Low-Income Persons With Mental Health Disorders.

Mayo Clin Proc Innov Qual Outcomes

February 2025

Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester.

Objective: To evaluate the use of complementary and integrative medicine (CIM) among a low-income population with mental health diagnoses and to assess differences in social determinants of health (SDOH) on the basis of CIM use.

Patients And Methods: We surveyed patients with mental health diagnoses and/or substance use disorders during outpatient evaluations between August 11, 2020, and November 18, 2021, at a community behavioral health center in Rochester, MN. We measured knowledge of current CIM, interest in future use of CIM, and SDOH.

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The stability improvements of dye-sensitized solar cell with natural template for photoanode using lignin extracted from rice husk.

Heliyon

January 2025

Advanced Functional Materials Research Group, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung, 40132, Indonesia.

In response to escalating global concerns over environmental pollution, the development of green dye-sensitized solar cells (DSSCs) has emerged as a promising technology for solar energy conversion. This study harnesses the potential of rice husk, an abundant agricultural waste in Indonesia, by extracting lignin through a simple recycling method. Lignin acts as a natural, non-toxic dopant and template for TiO₂ composites, enhancing the stability of the photoanode in DSSCs.

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Background: Healthcare systems need to address the high healthcare use of frail older adults. The Geriatric Services Hub (GSH) is a novel program in Singapore that delivers frailty screening, comprehensive geriatric assessment and coordinated care for community-dwelling older persons with bio-psycho-social needs. We aimed to evaluate the effects of the GSH on healthcare use.

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Medical misinformation (false health or medical-related information) has seen a rapid increase in volume recently, with the global surge in social media usage and further exacerbation by the COVID-19 pandemic. This may put more lives at stake, as misinformation is an often-cited reason that people make dangerous health choices, engage in harmful practices and reject beneficial health treatments. In this article, we explore the drivers and consequences, as well as suggest several strategies at the personal, educational and systemic level, for physicians to guide and communicate with patients who subscribe to medical misinformation.

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Molecular Mechanisms of Synergistic Effect of PRIMA-1 and Oxaliplatin in Colorectal Cancer With Different p53 Status.

Cancer Med

January 2025

Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China.

Article Synopsis
  • The study investigates combining PRIMA-1 with oxaliplatin (L-OHP) to enhance treatment efficacy for colorectal cancer (CRC) while addressing the drug's toxicity and resistance issues.
  • The results show that the combination therapy significantly improves cancer cell death and reduces cell migration and colony formation, regardless of p53 mutation status.
  • RNA-seq analysis reveals different cellular responses to the treatments based on p53 status, and in vivo studies confirm that the combination therapy enhances effectiveness and reduces toxicity compared to PRIMA-1 alone.
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Article Synopsis
  • Antidepressants, particularly Tricyclics (TCAs) and some new treatments, may increase the risk of cataracts, while others like Tetracyclics (TeCAs) and Monoamine Oxidase Inhibitors (MAOIs) appear to lower that risk.
  • Several types of antidepressants, including SSRIs and SNRIs, have been linked to an increased risk of glaucoma, with risk ratios (RORs) showing significant associations.
  • However, the study is limited by potential duplicate reports in the FDA database, and causality can't be definitively established. Overall, most antidepressants investigated were linked to lower cataract risk, but caution is needed in interpreting these findings
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Clinical guidelines typically endorse conventional therapies such as 5-aminosalicylic acid (5-ASA) as the mainstay of ulcerative colitis management. However, the degree of adoption and application of guideline recommendations by physicians within Asia remains unclear. This study aims to understand the prescribing patterns of 5-ASA and implementation of current guideline recommendations across Asian clinical practice.

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