160,089 results match your criteria: "Singapore; KK Women's and Children's Hospital[Affiliation]"

As one of the typical applications of metamaterials, the invisibility cloak has raised vast research interests. After many years' research efforts, the invisibility cloak has extended its applicability from optics and acoustics to electrostatics and thermal diffusion. One scientific challenge that has significantly restricted the practical application of the invisibility cloak is the strong background dependence, that is, all passive cloaking devices realized thus far are unable to resist variation in the background refractive index.

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Article Synopsis
  • Vedolizumab is an advanced treatment option for ulcerative colitis (UC) that can be effective but can lead to a loss of response over time, prompting the need to identify predictive factors for maintaining remission.
  • Researchers used logistic regression on participants from a study to create a VIEWS scoring system that assesses the likelihood of continuing remission after two years.
  • The study found that factors like gender, treatment history, and baseline health status were significant predictors, with the VIEWS score showing strong accuracy in predicting remission outcomes in two different patient cohorts.
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Objective: Identification of patients with head-and-neck malignancies who are especially vulnerable to malnutrition is critical for optimizing outcomes. The objectives are; to correlate Bioelectrical-impendence-analysis (BIA) parameters with Subjective-Global-Assessment (SGA) scores, and determine the association of BIA parameters with common perioperative complications in patients undergoing head-and-neck surgery.

Study Design: Patients underwent formal SGA scoring and BIA preoperatively in a multidisciplinary allied health clinic.

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A perspective on field-effect in energy and environmental catalysis.

Chem Sci

December 2024

Hunan Joint International Research Center for Carbon Dioxide Resource Utilization, State Key Laboratory of Powder Metallurgy, School of Physics, Central South University Changsha 410083 P. R. China

The development of catalytic technologies for sustainable energy conversion is a critical step toward addressing fossil fuel depletion and associated environmental challenges. High-efficiency catalysts are fundamental to advancing these technologies. Recently, field-effect facilitated catalytic processes have emerged as a promising approach in energy and environmental applications, including water splitting, CO reduction, nitrogen reduction, organic electrosynthesis, and biomass recycling.

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Consensus on the lung cancer management after third-generation EGFR-TKI resistance.

Lancet Reg Health West Pac

December 2024

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Article Synopsis
  • Lung cancer is the most common type of cancer in the Asia-Pacific region, with non-small cell lung cancer (NSCLC) making up about 85% of cases, and a significant mutation rate of 40-60% in Asian patients with lung adenocarcinoma.
  • Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) have improved treatment for NSCLC with mutations, but managing resistance to these drugs is still a major issue with no standardized guidelines.
  • A set of recommendations has been developed, integrating international guidelines and regional clinical experiences, to help healthcare providers classify resistance, conduct clinical testing, and devise treatment strategies for patients struggling with resistance to third-generation EGFR-TKIs.
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Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature.

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Article Synopsis
  • The generation of specific molecules is important in fields like biology and drug discovery, but existing models struggle with complex customization based on detailed language.
  • TextSMOG is a new method that combines language and diffusion models to allow for text-guided small molecule generation, enhancing stability and diversity.
  • Experimental results demonstrate that TextSMOG effectively uses textual descriptions to generate 3D molecular structures tailored to complex requests.
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Medical applications and prospects of polylactic acid materials.

iScience

December 2024

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.

Article Synopsis
  • Polylactic acid (PLA) is an environmentally friendly polymer that biodegrades and is made from renewable resources, making it a strong alternative to traditional plastics.
  • PLA is biocompatible and non-toxic, which improves safety in medical applications by minimizing tissue reactions and eliminating the need for additional surgeries due to its natural breakdown.
  • Recent advancements in nanotechnology and 3D printing have enhanced PLA’s structural and biological properties, expanding its use in drug delivery systems, orthopedic treatments, tissue engineering, and medical devices.
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Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.

Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).

Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions.

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Use of Complementary and Integrative Medicine Among Low-Income Persons With Mental Health Disorders.

Mayo Clin Proc Innov Qual Outcomes

February 2025

Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester.

Objective: To evaluate the use of complementary and integrative medicine (CIM) among a low-income population with mental health diagnoses and to assess differences in social determinants of health (SDOH) on the basis of CIM use.

Patients And Methods: We surveyed patients with mental health diagnoses and/or substance use disorders during outpatient evaluations between August 11, 2020, and November 18, 2021, at a community behavioral health center in Rochester, MN. We measured knowledge of current CIM, interest in future use of CIM, and SDOH.

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The stability improvements of dye-sensitized solar cell with natural template for photoanode using lignin extracted from rice husk.

Heliyon

January 2025

Advanced Functional Materials Research Group, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung, 40132, Indonesia.

In response to escalating global concerns over environmental pollution, the development of green dye-sensitized solar cells (DSSCs) has emerged as a promising technology for solar energy conversion. This study harnesses the potential of rice husk, an abundant agricultural waste in Indonesia, by extracting lignin through a simple recycling method. Lignin acts as a natural, non-toxic dopant and template for TiO₂ composites, enhancing the stability of the photoanode in DSSCs.

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Background: Healthcare systems need to address the high healthcare use of frail older adults. The Geriatric Services Hub (GSH) is a novel program in Singapore that delivers frailty screening, comprehensive geriatric assessment and coordinated care for community-dwelling older persons with bio-psycho-social needs. We aimed to evaluate the effects of the GSH on healthcare use.

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Medical misinformation (false health or medical-related information) has seen a rapid increase in volume recently, with the global surge in social media usage and further exacerbation by the COVID-19 pandemic. This may put more lives at stake, as misinformation is an often-cited reason that people make dangerous health choices, engage in harmful practices and reject beneficial health treatments. In this article, we explore the drivers and consequences, as well as suggest several strategies at the personal, educational and systemic level, for physicians to guide and communicate with patients who subscribe to medical misinformation.

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Molecular Mechanisms of Synergistic Effect of PRIMA-1 and Oxaliplatin in Colorectal Cancer With Different p53 Status.

Cancer Med

January 2025

Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China.

Article Synopsis
  • The study investigates combining PRIMA-1 with oxaliplatin (L-OHP) to enhance treatment efficacy for colorectal cancer (CRC) while addressing the drug's toxicity and resistance issues.
  • The results show that the combination therapy significantly improves cancer cell death and reduces cell migration and colony formation, regardless of p53 mutation status.
  • RNA-seq analysis reveals different cellular responses to the treatments based on p53 status, and in vivo studies confirm that the combination therapy enhances effectiveness and reduces toxicity compared to PRIMA-1 alone.
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Article Synopsis
  • Antidepressants, particularly Tricyclics (TCAs) and some new treatments, may increase the risk of cataracts, while others like Tetracyclics (TeCAs) and Monoamine Oxidase Inhibitors (MAOIs) appear to lower that risk.
  • Several types of antidepressants, including SSRIs and SNRIs, have been linked to an increased risk of glaucoma, with risk ratios (RORs) showing significant associations.
  • However, the study is limited by potential duplicate reports in the FDA database, and causality can't be definitively established. Overall, most antidepressants investigated were linked to lower cataract risk, but caution is needed in interpreting these findings
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Clinical guidelines typically endorse conventional therapies such as 5-aminosalicylic acid (5-ASA) as the mainstay of ulcerative colitis management. However, the degree of adoption and application of guideline recommendations by physicians within Asia remains unclear. This study aims to understand the prescribing patterns of 5-ASA and implementation of current guideline recommendations across Asian clinical practice.

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Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with typical therapeutic strategies targeting genes or enzymes being ineffective in this domain. In this report, we demonstrate that an antibody targeting the isoDGR damage motif in lung tissue can guide immune clearance of harmful damaged proteins in vivo, effectively reducing age-linked lung inflammation.

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Label noise is a common and important issue that would affect the model's performance in artificial intelligence. This study assessed the effectiveness and potential risks of automated label cleaning using an open-source framework, Cleanlab, in multi-category datasets of fundus photography and optical coherence tomography, with intentionally introduced label noise ranging from 0 to 70%. After six cycles of automatic cleaning, significant improvements are achieved in label accuracies (3.

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The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex.

Med Res Rev

January 2025

Department of Microbiology and Immunology, Infectious Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.

The Semliki Forest virus (SFV) complex comprises of arboviruses that are transmitted by arthropod vectors and cause acute febrile illness in humans. In the last seven decades, re-emergence of these viruses has resulted in numerous outbreaks globally, affecting regions including Africa, Americas, Asia, Europe and the Caribbean. These viruses are transmitted to humans by the bite of infected mosquitoes.

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Background: To evaluate the 6-year physiological rates-of-change in ganglion cell inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) thickness measured with optical coherence tomography.

Methods: We included 2202 out of 2661 subjects from the population-based Singapore Chinese Eye Study who returned for follow-up 6 years after baseline examination (follow-up rate 87.7%).

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Background: Crimean-Congo hemorrhagic fever is a tick-borne zoonotic disease that may be severe and is present in many African countries. We aimed to understand the seroprevalence and risk for Crimean-Congo hemorrhagic fever virus in Tanzania by testing archived serum samples from patients enrolled in a prospective cohort study.

Methods: We prospectively enrolled febrile inpatients and outpatients from 2012 through 2014 at two referral hospitals in northern Tanzania.

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Single-Cell RNA Sequencing Reveals Age-Related Changes in Epidermal Cell Populations and Interactions.

J Invest Dermatol

January 2025

Department of Dermatology Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; A*STAR Skin Research Labs (A*SRL) and Skin Research Institute of Singapore (SRIS), Agency for Science, Technology, and Research (A*STAR), 8A Biomedical Grove, IMMUNOS Building, Biopolis, 138648 Singapore. Electronic address:

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Background: GLOB-cAGE is a newly established unprecedented consortium that brings together cohorts of older persons with cardiovascular disease worldwide. GLOB-cAGE aims to harmonize non-identifiable data from longitudinal cohorts examining cardiovascular health and cardiovascular disease diagnosis and management in older individuals to perform meta-regression analyses using combined repositories of standardized subject-level data points.

Methods And Design: Studies registered into GLOB-cAGE are population-based longitudinal cohort studies or clinical trials, either ongoing or completed, that involve assessing cardiovascular health as a central objective.

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China, the world's largest carbon emitter, plays a pivotal role in achieving carbon neutrality. This study systematically analyzes the impact of landscape indices on carbon emissions from rural settlements across more than 2800 counties using eight supervised machine learning models. To assess variable influences under diverse conditions, we also employed the SHapley Additive exPlanations (SHAP) and Accumulated Local Effects (ALE) methods.

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