160,929 results match your criteria: "Singapore; Institute of Molecular and Cell Biology IMCB[Affiliation]"

We examined the relationship between socioeconomic status (SES) and endorsement of honour. We studied the SES-honour link in 5 studies (N = 13,635) with participants recruited in different world regions (the Mediterranean and MENA, East Asian, South-East Asian, and Anglo-Western regions) using measures that tap into various different facets of honour. Findings from these studies revealed that individuals who subjectively perceived themselves as belonging to a higher (vs.

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To explore the chain mediating role of social support and trust in between decision self-efficacy and decision conflict of stroke caregivers. Convenient sampling was used to select stroke caregivers who were admitted to the department of neurology, neurosurgery and rehabilitation in a four-3A hospital in Henan Province from September 2023 to April 2024. General information questionnaire, Decisional Self-efficacy Scale, Social Support Scale, Wake Forest Physician Trust Scale and Decisional Conflict Scale were adopted.

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Congenital infantile brainstem high-grade gliomas (HGGs) are extremely rare. Given the limited literature characterizing this disease, management of these tumors remains challenging. Brainstem HGGs are generally associated with extremely poor prognosis.

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Variations in land surface temperature increase in South-East Asian Cities.

Environ Monit Assess

January 2025

Mathematics Department, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia.

Climate change and global warming are terms used to describe the variation in the Earth's mean temperature as a result of human activities contributing to the formation of urban heat islands (UHI). One method for determining the temperature of a region is the land surface temperature (LST). The study of LSTs is important and closely related to climate change, as is the provision of convenient living and working conditions in cities, which support economic growth.

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There remains a scarcity of studies to evaluate the treatment effect of electroconvulsive therapy (ECT). Functional near-infrared spectroscopy (fNIRS) offers a cost-effective method to measure cerebral hemodynamics. This study used fNIRS to evaluate the effect of ECT in patients suffering from schizophrenia or bipolar disorder (manic phase).

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This study introduces EpiAgePublic, a new method to estimate biological age using only three specific sites on the gene known for its connection to aging. Unlike traditional methods that require complex and extensive data, our model uses a simpler approach that is well-suited for next-generation sequencing technology, which is a more advanced method of analyzing DNA methylation. This new model overcomes some of the common challenges found in older methods, such as errors due to sample quality and processing variations.

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Background: Epidemiologic studies have shown that daily exposure to incense smoke is associated with greater risk of cardiovascular mortality, which suggests that chronic exposure to incense could be linked to atherosclerosis. We studied the association between home incense use and the risk of chronic limb-threatening ischemia (CLTI), the most severe outcome of peripheral arterial disease.

Methods: We used data from the Singapore Chinese Health Study, which recruited 63,257 Chinese participants 45-74 years old from 1993-1998.

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Pertussis Vaccination for Adults: An Updated Guide for Clinicians.

Vaccines (Basel)

January 2025

Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore 119074, Singapore.

Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the Gram-negative bacterium . Although traditionally associated with children, pertussis is increasingly prevalent among adults, particularly those with comorbidities or weakened immune systems, where it can lead to severe complications. Diagnosing pertussis in adults can be challenging due to its nonspecific symptoms, underreporting, and the limited sensitivity of available diagnostic tests.

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Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling.

Vaccines (Basel)

January 2025

Vaccine and Infectious Diseases Organization (VIDO), University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada.

Adjuvants are a diverse group of substances that can be added to vaccines to enhance antigen-specific immune responses and improve vaccine efficacy. The first adjuvants, discovered almost a century ago, were soluble crystals of aluminium salts. Over the following decades, oil emulsions, vesicles, oligodeoxynucleotides, viral capsids, and other complex organic structures have been shown to have adjuvant potential.

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Reflections on COVID-19: A Literature Review of SARS-CoV-2 Testing.

Vaccines (Basel)

December 2024

Department of Laboratory Medicine, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore.

Although the Coronavirus disease 2019 (COVID-19) pandemic has ended, there are still many important lessons we can learn, as the pandemic profoundly affected every area of laboratory practice. During the pandemic, extensive changes to laboratory staffing had to be implemented, as many healthcare institutions required regular screening of all healthcare staff. Several studies examined the effectiveness of different screening regimens and concluded that repeated testing, even with lower sensitivity tests, could rival the performance of gold-standard RT-PCR testing in the detection of new cases.

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This study optimizes the CuO/GaO heterojunction diodes (HJDs) by tailoring the structural parameters of CuO layers. The hole concentration in the sputtered CuO was precisely controlled by adjusting the Ar/O gas ratio. Experimental investigations and TCAD simulations were employed to systematically evaluate the impact of the CuO layer dimension and hole concentration on the electrical performance of HJDs.

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: Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder characterized by intermittent upper airway obstruction, leading to significant health consequences. Traditional diagnostic methods, such as polysomnography, are time-consuming and resource-intensive. : This study explores the potential of proton-transfer-reaction mass spectrometry (PTR-MS) in identifying volatile organic compound (VOC) biomarkers for the non-invasive detection of OSA.

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This study evaluated metabolites and lipid composition in the calf muscles of Type 2 diabetes mellitus (T2DM) patients and age-matched healthy controls using multi-dimensional MR spectroscopic imaging. We also explored the association between muscle metabolites, lipids, and intra-abdominal fat in T2DM. Participants included 12 T2DM patients (60.

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Background: Severe aortic stenosis (AS) stratified by sex has been increasingly studied in the European population. Sex-specific outcomes in Asian patients with AS remain poorly defined. Hence, we aimed to study the clinical characteristics and impact of sex in moderate-to-severe AS, undergoing both invasive and conservative interventions in an Asian cohort over 10 years.

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The large-scale implementation of 2D material-based membranes is hindered by mechanical stability and mass transport control challenges. This work describes the fabrication, characterisation, and testing of self-standing graphene oxide (GO) membranes cross-linked with oxides such as FeO, AlO, CaSO, NbO, and a carbide, SiC. These cross-linking agents enhance the mechanical stability of the membranes and modulate their mass transport properties.

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Enhancing CO Adsorption on MgO: Insights into Dopant Selection and Mechanistic Pathways.

Biomimetics (Basel)

December 2024

Entropic Interface Group, Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore.

Inspired by our recent success in designing CO-phobic and CO-philic domains on nano-MgO for effective CO adsorption, our ongoing efforts focus on incorporating dopants into pristine MgO to further enhance its CO adsorption capabilities. However, a clear set of guidelines for dopant selection and a holistic understanding of the underlying mechanisms is still lacking. In our investigation, we combined first-principles calculations with experimental approaches to explore the crystal and electronic structural changes in MgO doped with high-valence elements (Al, C, Si, and Ti) and their interactions with CO.

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Some New Constructions of -ary Codes for Correcting a Burst of at Most Deletions.

Entropy (Basel)

January 2025

Science, Mathematics and Technology (SMT) Cluster, Singapore University of Technology and Design, Singapore 487372, Singapore.

In this paper, we construct -ary codes for correcting a burst of at most deletions, where t,q≥2 are arbitrarily fixed positive integers. We consider two scenarios of error correction: the classical error correcting codes, which recover each codeword from one read (channel output), and the reconstruction codes, which allow to recover each codeword from multiple channel reads. For the first scenario, our construction has redundancy logn+8loglogn+o(loglogn) bits, encoding complexity O(q7tn(logn)3) and decoding complexity O(nlogn).

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Vertical Federated Learning (VFL) is a promising category of Federated Learning that enables collaborative model training among distributed parties with data privacy protection. Due to its unique training architecture, a key challenge of VFL is high communication cost due to transmitting intermediate results between the Active Party and Passive Parties. Current communication-efficient VFL methods rely on using stale results without meticulous selection, which can impair model accuracy, particularly in noisy data environments.

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Management of Anterior Choroidal Artery Aneurysms: A Retrospective Cohort Study.

Brain Sci

December 2024

Division of Neurointerventional Radiology, UMass-Chan Lahey Department of Radiology, Lahey Hospital and Medical Centre-Beth Israel Lahey Health, Burlington, MA 01805, USA.

Anterior choroidal artery (AChoA) aneurysms pose a challenge for both endovascular and clipping procedures. The eloquent territory supplied by the parent vessel has limited collateralization and its compromise can lead to significant morbidity. This study aims to analyze the clinical outcomes and procedure-related complications of clipping and endovascular treatment of AChoA aneurysms to aid physician decision making.

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Terahertz (THz) waves reside in the electromagnetic spectrum between the microwave and infrared bands. In recent decades, THz technology has demonstrated its potential for biomedical applications. With the highly unique characteristics of THz waves, such as the high sensitivity to water and optimal spatial resolution coupled with the characteristics of the human cornea, such as its high water content, THz technology has been explored as a potential modality to assess corneas and corneal diseases.

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Objective: To evaluate the utility of three-dimensional (3D) anatomical models as an educational tool among Orthopaedic surgical trainees.

Methods: Seven types of 3D anatomical models - humerus, elbow, ankle, calcaneum, knee, femur, and pelvis- based on patients' computational tomography (CT) scans were printed in the study institution and used by surgical trainees preoperatively. Responses were collected in the form of a Likert scale questionnaire.

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Purpose: When performed for clinically significant carotid artery stenosis (CAS), the long-term impact of carotid endarterectomy (CEA) on choroidal and choriocapillaris (CC) circulation was studied using swept-source OCT angiography.

Design: Prospective observational study.

Participants: Patients with clinically significant CAS undergoing unilateral CEA.

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Objective: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Increasing evidence suggests that it is potentially related to gut microbiota, but no prior bibliometric analysis has been performed to explore the most influential works in the relationships between ASD and gut microbiota. In this study, we conducted an in-depth analysis of the most-cited articles in this field, aiming to provide insights to the existing body of research and guide future directions.

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In this viewpoint, we explore Vietnam's health system vulnerabilities and its national response to the COVID-19 pandemic, as well as critical areas of health system resilience, including health financing, workforce distribution, information systems, and governance. While Vietnam achieved early success through strong governance and mass vaccination campaigns, the pandemic revealed weaknesses in resource procurement, workforce imbalance, and limitations of its health information system. There are challenges in ensuring the rapid disbursement of financial resources and reliance on imported medical supplies, which delayed response times.

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