The Empowerment of Adolescents with Type 1 Diabetes Is Associated with Their Executive Functions.

Background: Adolescence is a difficult period for young people with type 1 diabetes mellitus (T1DM), both in psychological and clinical terms. Empowerment therapy may support these patients, provided they are ready to change and have adequate executive functions to facilitate this change. Therefore, we hypothesise that the readiness of adolescents with T1DM to change is related to clinical features and/or their executive functions.

[Chronologia terapeutyczna w leczeniu czerniaka skóry - opis przypadku].

Unlabelled: Skin melanomas rank among the malignant neoplasms that have the greatest dynamics of growth and number of incidents. Early identification of primary lesions and metastases in regional lymph nodes, possible due to location, creates a chance for complete recovery.

Case Report: The study presents a positive result of treatment in case of a 67-year old woman patient, with diagnosed malignant melanoma in the lateral ankle area in the right lower extremity.

Role of copeptin in dual-cardiac marker strategy for patients with chest pain presented to ED.

Objective: The objective of the study is to evaluate the role of copeptin in the diagnosis of acute coronary syndrome (ACS) and its role in dual-cardiac marker diagnostic strategy with troponin.

Design: A prospective cohort study was carried out from May 2012 to October 2012.

Setting: The study was conducted at the emergency department (ED) of a public hospital in a cluster of Hong Kong.

The effect of central noradrenergic system lesion on dopamine (DA) and serotonin (5-HT) synthesis rate following administration of 5-HT3 receptor ligands in chosen parts of the rat brain.

Introduction: Since little has been known about the effect of the central noradrenergic system on the reactivity of serotonin 5-HT3 receptors, the aim of the current study was to find out whether this reactivity could be altered by chemical damage to the system in adult rats in early developmental stage.

Materials And Methods: Adult male Wistar rats with central noradrenergic lesion induced by DSP-4 on day 1 and 3 of life were injected with analgesic model substance - morphine, serotoninergic 5-HT3 receptor agonist (1-phenylbiguanide, PBG), 5-HT3 receptor antagonist (ondansetron) or both compounds jointly followed by decarboxylase inhibitor of aromatic amino acids (NSD-1050). After 30 min following NSD-1050 injection, the animals were decapitated using a guillotine.

Genetic variability of GCKR alters lipid profiles in children with monogenic and autoimmune diabetes.

Purpose: Mutations in the glucokinase (GCK) gene are associated with altered blood glucose and lipid concentrations. Our aim was to assess the effects on HbA1c and serum lipid levels of single nucleotide polymorphisms (SNPs) in 2 genes encoding proteins that interact with glucokinase: glucose-6-phospatase catalytic subunit 2 (G6PC2) and glucokinase regulatory protein (GCKR).

Methods: The study group included 129 children with GCK-MODY from the Polish Registry of Monogenic Diabetes and 395 with type 1 diabetes (T1DM), in whom we genotyped 2 SNPs in G6PC2 (rs560887) and GCKR (rs1260326).

Copeptin: a new marker in cardiology.

Copeptin, the C-terminal part of the prohormone of vasopressin (AVP), is released together with AVP in stoichiometric concentrations reflecting an individual's stress level. Copeptin has come to be regarded as an important marker for identifying high-risk patients and predicting outcomes in a variety of diseases. It improves the clinical value of commonly used biomarkers and the tools of risk stratification.

Prevalence of monogenic diabetes amongst Polish children after a nationwide genetic screening campaign.

Aims/hypothesis: The aim of this study was to study dynamic changes in the prevalence of different types of diabetes in paediatric populations in Poland, with a specific focus on monogenic diabetes (MD).

Methods: Using epidemiologic data (PolPeDiab Collaboration) and nationwide genetic test results (TEAM Programme), we compared the prevalence of type 1, type 2 and cystic fibrosis-related diabetes (CFRD) and MD. Genetically confirmed MD included MODY, neonatal diabetes and Wolfram and Alström syndromes.

[Problems of diagnosis and therapy of primary hyperparathyroidism--case report].

Primary hyperparathyroidism is systemic, polymorphic disease. Authors present a case of woman suffered from primary hyperparathyroidism misdiagnosed as disseminated neoplastic disease. There was shown a clinical picture complex, difficulties in diagnostic process, treatment and factors provided mistakes in therapy.

[Vaccination against influenza--recommendations and reality in the assessments of patients of cardiology and family physician center].

Unlabelled: Influenza is one of the most common diseases in the world. It occurs seasonally and is a viral disease contracted by a direct contact (respiratory droplets), causing many serious complications. The best way to prevent influenza is to get vaccinated once a year, which is the cheapest and the most effective protection.

[B hepatitis vaccination evaluated in population of non-medical staff members].

Unlabelled: Hepatitis belongs to a group of diseases caused by different hepatotropic viruses, which are responsible for inflamation of the liver. The most common form of liver infection is hepatitis B virus (HBV). It is transmitted by blood and other body fluids.

[Biological agents in treatment of psoriatic arthritis].

Psoriatic arthritis was reported in approximately 6-39% of patients with psoriasis. It is a chronic disease that commonly leads to disability. The paper reviews TNF-alpha inhibitors, the drugs which resulted in a substantial progress in management of psoriatic arthritis.

[Adrenopause].

The hypothalamic-pituitary-adrenal axis activity in the aging people is characterised by an unexplained reduction of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) secretion while ACTH and cortisol production remains relatively unchanged. This decline in the biological activity of the zona reticularis, referred to as 'adrenopause', may contribute to the physiology of human aging. The reduced endogenous concentrations of DHEA and DHEAS found in advancing age have been correlated with a constellation of health problems.

[Langerhans' cell histiocytosis--diagnostic and treatment difficulties].

Unlabelled: Langerhans' cell histiocytosis [(LCH), histiocytosis X] is a very rare disease, which can involve any side and organ of the body. LCH may appear as an isolated leasion or as a widespread systemic disease. Focus in the bone as eosinophilic granuloma can be separate or be involved only as a part of generalized disease.

[Hormonal factors in aetiopathogenesis of psoriasis].

Psoriasis is one of the most common chronic and recurrent dermatosis. Aetiopathogenesis of this disease is complex and not yet well known. Lately, besides many different factors regarded to play an important role in psoriasis pathology, hormones have been taken into account, too.

[Insulinoma].

Insulinoma is considered the most common endocrine tumour of the pancreas with an annual prevalence of 4 cases per million people. Contrary to the other endocrine tumours of this organ, over 90% of the insulinomas are benign in nature. The clinical presentation of this neoplasm depends on excessive production of insulin and pro-insulin and is characterised by the symptoms of neuroglycopenia and catecholamine response.

Causes and effects of zygomatico-orbital and zygomatico-maxillo-orbital fractures managed by open reduction and rigid internal fixation.

Progressive violence, the quickening pace of life and transport facilities' development have as a consequence an increased number of traumas. Midface fractures involving zygomatic bone fractures take one of the leading positions in the total number of traumas. It seems appropriate to study the causes and the effects of zygomatico-orbital and zygomatico-maxillo-orbital fractures managed by open reduction and rigid internal fixation at the present time of the medical service being reformed and economic rules being included in the treatment.