Antidiabetic potency of glimepiride and naringin: an and investigation.

Glimepiride (GLM) is one of the potential antidiabetic drugs used in clinics for a long time. It is currently used in combination with metformin along with other drugs, but has shown various complications in patients from long-term use. Thus, the hypothesis is to use a lower dose of GLM with a non-toxic class of flavonoid, naringin (NARN), for better therapy with minimal side-effects.

Causes and risk factors for stillbirth in India: A systematic review protocol.

Objectives: Stillbirths, the tragic loss of a baby before or during delivery, presents a profound global health concern. Investigating the diverse causes and risk factors is essential to develop targeted interventions, enhance perinatal care, and reduce the incidence of this devastating outcome. The aim of this study was to identify the causes and possible risk factors of stillbirths in India.

Continuous tremor monitoring in Parkinson's disease: A wristwatch-inspired triboelectric sensor approach.

Parkinson's disease (PD) prevalence is projected to reach 12 million by 2040. Wearable sensors offer a promising approach for comfortable, continuous tremor monitoring to optimize treatment strategies. Here, we present a wristwatch-like triboelectric sensor (WW-TES) inspired by automatic watches for unobtrusive PD tremor assessment.

Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes.

Nanomedicine offers a promising avenue for improving retinal drug delivery, effectively addressing challenges associated with ocular diseases like age-related macular degeneration and diabetic retinopathy. Nanoparticles, with their submicron size and customisable surface properties, enable enhanced permeability and retention within retinal tissues, supporting sustained drug release and minimising systemic side effects. Nanostructured scaffolds further provide a supportive environment for retinal cell growth and tissue regeneration, crucial for treating degenerative conditions.

Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects-A Prospective, Comparative Clinical Study.

Background: Periodontal intra-bony defects are challenging conditions in dental practice, often requiring regenerative approaches for successful treatment. This clinical study aimed to compare the effectiveness of plasma rich in growth factors (PRGF) versus xenogenic bone graft (BXG) in addressing intra-bony defects.

Methods: Forty patients aged between 30 and 50 years presenting with generalized periodontitis were included.

Revolutionizing DNA: advanced modification techniques for next-gen nanotechnology.

The comprehensive advancement in DNA modification and coupling is driving DNA nanotechnology to new heights, paving the way for groundbreaking innovations in healthcare, materials science, and beyond. The ability to engineer DNA with tailored properties and functionalities underscores its immense potential in creating novel materials and devices. Utilizing a spectrum of techniques-such as amino handles, thiol groups, alkynes, azides, Diels-Alder reactions, hydrazides, and aminooxy functions-enables diverse coupling strategies, including Palladium-Catalyzed Couplings, to construct intricate DNA nanostructures.

Lipid nanocarrier-based bigel of oil for analgesic and anti-inflammatory applications.

Present study reports analgesic and anti-inflammatory potential of (L.) leaf oil loaded lipid nanocarrier (BLNs)-embedded bigel. BLNs were developed by solvent evaporation technique and were characterised by FESEM, Cryo-TEM, mean diameter, zeta potential, loading efficiency, etc.

Psychological well-being of travellers on long-distance shipping voyages: A systematic review protocol.

The psychosocial well-being of every individual is as important as the well-being of long-distance voyages, especially that they have to spend longer hours and days travelling to their destinations with all the experiences of adventure and adversities characterizing the journey. The aim of this systematic review is to explore the psychosocial well-being of long-distance seafarers on board shipping vessels to gain an understanding of their psychological and social well-being with the objective of ameliorating the adversities associated with these travels. A systematic review will be conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (2020) statement.

Harnessing machine learning technique to authenticate differentially expressed genes in oral squamous cell carcinoma.

Objective: Advancements in early detection of the disease, prognosis and the development of therapeutic strategies necessitate tumor-specific biomarkers. Despite continuous efforts, no molecular marker has been proven to be an effective therapeutic tool for the early detection of cancer. The study aims to determine diagnostic and prognostic signature genes that may be involved in cancer pathology and hence, may serve as molecular markers.

Enhancing the Phytoremediation of Heavy Metals by Plant Growth Promoting Rhizobacteria (PGPR) Consortium: A Narrative Review.

Heavy metal pollution has become a significant concern as the world continues to industrialize, urbanize, and modernize. Heavy metal pollutants impede the growth and metabolism of plants. The bioaccumulation of heavy metals in plants may create chlorophyll antagonism, oxidative stress, underdeveloped plant growth, and reduced photosynthetic system.

Plant membrane transporters function under abiotic stresses: a review.

In the present review, we discussed the detailed signaling cascades via membrane transporters that confer plant tolerance to abiotic stresses and possible significant use in plant development for climate-resilient crops. Plant transporters play significant roles in nutrient uptake, cellular balance, and stress responses. They facilitate the exchange of chemicals and signals across the plant's membrane by signal transduction, osmotic adjustment, and ion homeostasis.

Rodent models for oral microbiome research: considerations and challenges- a mini review.

Rodent models have been commonly employed in oral microbiota research to investigate the relationship between bacteria and oral disease. Nevertheless, to apply the knowledge acquired from studies conducted on rodents to a human context, it is crucial to consider the significant spatial and temporal parallels and differences between the oral microbiota of mice and humans. Initially, we outline the comparative physiology and microbiology of the oral cavity of rodents and humans.

Estimation of Crestal Bone Loss with Flap and Flapless Methods for the Position of Implant.

Introduction: The current research was conducted to estimate the loss of crestal bone using the flap and flapless method for implant placement.

Materials And Methods: Forty participants who fulfilled the addition criteria were chosen for this research. All participants were then categorized equally into two study groups, that is, with and without undergoing flap surgery.

A hybrid approach for power quality event identification in power systems: Elasticnet Regression decomposition and optimized probabilistic neural networks.

The transformation of traditional grid networks towards smart-grid and microgrid concepts raises many critical issues, and quality in the power supply is one of the prominent ones that needs further research. Developing and applying power quality (PQ) recognition methods with efficient and reliable analysis are essential to the fast-growing issues related to modern smart power distribution systems. In this regard, a hybrid algorithm is proposed for PQ events detection and classification using Elasticnet Regression-based Variational Mode Decomposition (ER-VMD) and Salp Swarm Algorithm optimized Probabilistic Neural Network (SSA-PNN).

Organic acid-fractionated lignin silver nanoparticles: Antimicrobial, anticancer, and antioxidant characteristics.

Bioactive substances are utilized to treat a variety of diseases. Green lignin-mediated silver nanoparticles (L-Ag-NPs) have significant promise as a building block in the production of bio-renovation materials. The work optimized organic acid extraction to remove lignin from residual fermented hybrid Napier grass byproducts.

Diagnostic Accuracy of Artificial Intelligence Compared to Biopsy in Detecting Early Oral Squamous Cell Carcinoma: A Systematic Review and Meta Analysis.

Objective: To summarize and compare the existing evidence on diagnostic accuracy of artificial intelligence (AI) models in detecting early oral squamous cell carcinoma (OSCC).

Method: Review was performed in accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis - Diagnostic Test Accuracy (PRISMA- DTA) checklist and the review protocol is registered under PROSPERO(CRD42023456355). PubMed, Google Scholar, EBSCOhost were searched from January 2000 to November 2023 to identify the diagnostic potential of AI based tools and models.

Network Pharmacology, Molecular Docking and in vivo-based Analysis on the Effects of the MBZM-N-IBT for Arthritis.

Introduction: Arthritis is the cause of morbidity associated with Chikungunya virus (CHIKV) infection. It persists even after the virus has been cleared from the body. MBZM-NIBT was earlier shown to inhibit (CHIKV) infection in vitro and in vivo.