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Histological variety of gastric carcinoma and Helicobacter pylori cagA and vacA polymorphism.

Eur J Gastroenterol Hepatol

September 2015

Departments of aMedical and Surgical Sciences and Neurosciences bMedical Biotechnology cMolecular and Developmental Medicine dHuman Pathology and Oncology, Section of Pathology, University of Siena, Siena eExperimental Zooprofilactic Institute of Lazio and Tuscany, Epidemiological Observatory, Rome, Italy.

Background: Helicobacter pylori infection may increase the risk of both histotypes of gastric carcinoma (GC): intestinal (IGC) and diffuse (DGC). Polymorphism of the main H. pylori virulence factors, cagA and vacA, could have a different impact on the histological variety of GC.

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