1,866 results match your criteria: "Sidney Kimmel Medical College at Thomas Jefferson University.[Affiliation]"

Article Synopsis
  • SARS-CoV-2 mutates over time, leading to new Variants of Concern (VOCs) that can affect how easily the virus spreads, the severity of illness, and how well current antiviral drugs work.
  • Recent antiviral drugs like Nirmatrelvir and Ensitrelvir inhibit specific viral proteins (3CLpro), while others like Remdesivir target different proteins (nsp12), but resistance mutations may diminish their effectiveness.
  • The review outlines key mutations in these viral proteins and discusses recent advancements in antiviral treatments, highlighting the concern of developing resistance as new variants emerge.
View Article and Find Full Text PDF

In 2011, the Society for Healthcare Epidemiology of America (SHEA) and Ronald McDonald House Charities® (RMHC®) established a formal collaboration to develop the first IPC guideline. Both organizations agreed that RMH programs staff and other organizations operating similar programs would benefit from a standardized approach. In 2023, the collaboration was re-established to revise and update the original IPC guideline.

View Article and Find Full Text PDF

Background: Despite increased awareness of persistent healthcare disparities, integrating health equity education into medical residency curricula needs urgent expansion. The Accreditation Council for Graduate Medical Education (ACGME) mandates addressing healthcare disparities and social determinants of health, but implementation remains insufficient due to pervasive barriers.

Objective: To explore residency faculty perspectives at one institution surrounding implementing a health equity curriculum within their programs.

View Article and Find Full Text PDF

Objective: To analyze antibiotic prescribing trends, particularly the decline in fluoroquinolone use for various genitourinary infection (GUI) and procedures and the growing preference for alternative treatments.

Methods: The TriNetX database was queried for antibiotic utilization rates from 2016 to 2022. We analyzed cases of cystitis, pyelonephritis, prostatitis, and other GUIs, as well as periprocedure utilization for benign prostatic hyperplasia, urethral stricture disease, pelvic organ prolapse/stress urinary incontinence, and overactive bladder/interstitial cystitis (OAB/IC).

View Article and Find Full Text PDF

A metabolic switch to the pentose-phosphate pathway induces radiation resistance in pancreatic cancer.

Radiother Oncol

January 2025

The Benjamin Davidai Department of Radiation Oncology, Sheba Medical Center, Derech Sheba 2, Ramat Gan 5265601, Israel; Tel-Aviv University, Chaim Levanon St. 55, Tel Aviv-Yafo 6997801, Israel; Sidney Kimmel Medical College at Thomas Jefferson University, 4201 Henry Ave, Philadelphia, PA 19144, USA. Electronic address:

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is remarkably resistant to standard modalities, including radiotherapy. We hypothesized that metabolic reprogramming may underlie PDAC radioresistance, and moreover, that it would be possible to exploit these metabolic changes for therapeutic intent.

Methods And Materials: We established two matched models of radioresistant PDAC cells by exposing the AsPC-1 and MIAPaCa-2 human pancreatic cancer cells to incremental doses of radiation.

View Article and Find Full Text PDF

Purpose: To report the visual outcomes and complications in eyes with retained lens fragments (RLF) following cataract surgery undergoing pars plana lensectomy (PPL) and scleral-fixated intraocular lens insertion (SFIOL).

Methods: Patients with RLF who underwent pars plana vitrectomy (PPV), PPL, and SFIOL insertion from January 2015 to December 2022 were included. The visual acuity (VA) outcomes and complication rates were compared between those receiving sutured versus sutureless SFIOL insertion as well as those undergoing SFIOL insertion at the time of PPV and PPL versus those undergoing SFIOL insertion during a subsequent surgery.

View Article and Find Full Text PDF

Reply.

Ophthalmology

November 2024

American Academy of Ophthalmology, San Francisco, California. Electronic address:

View Article and Find Full Text PDF
Article Synopsis
  • * A systematic review of literature identified 45 relevant studies, revealing significant variability in RTP protocols influenced by age, gender, and sport type, with early intervention and multidisciplinary approaches leading to better recovery.
  • * The authors emphasize the necessity for standardized, evidence-based RTP guidelines to improve concussion management, calling for further research to develop universal protocols that account for gender and sport-specific differences.
View Article and Find Full Text PDF

Role of preoperative CT imaging in penetrating thoraco-abdominal injuries: A multicenter study of urban trauma centers.

Am J Surg

January 2025

Department of Surgery, Division of Trauma and Surgical Critical Care, Drexel College of Medicine, Philadelphia, PA, USA; ChristianaCare Health System, Newark, DE, USA. Electronic address:

Introduction: Management of penetrating thoracoabdominal (PTA) injuries with signs of hemorrhage have warranted operative intervention but improved imaging capabilities have redefined interventions required. We examined outcomes of hemodynamically stable patients undergoing preoperative CT imaging with the hypothesis that CT imaging would decrease OR time without delaying OR arrival.

Methods: A retrospective multicenter study was performed amongst four urban trauma centers examining hemodynamically stable patients with PTA injuries requiring operative intervention from January 2017-December 2021.

View Article and Find Full Text PDF

An international physician survey of current ablation practices in atrial fibrillation: An AIM-AF substudy.

Heart Rhythm

October 2024

Clinical Cardiology Academic Group, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, United Kingdom.

Background: Practice guidelines recommend ablation (ABL) in atrial fibrillation (AF) for rhythm control. Guidance for antiarrhythmic drugs (AADs) post-ABL is limited.

Objective: The purpose of this study was to determine AAD and ABL practices in the United States and Europe.

View Article and Find Full Text PDF

A 79-year-old woman with psoriasis presented to the emergency department with new-onset eruptions on the trunk, extremities, and oral mucosa for 8-9 days. For psoriasis, she had been taking 15 mg of methotrexate weekly for over 18 years, and had discontinued folic acid a few months prior to this.

View Article and Find Full Text PDF

Judging whether an editor is good at the job is essential; however, this task may be difficult or even impossible. Several factors are involved, many of which are beyond the control of an editor. We examined some of such situations, which are as follows: (1) Reviewer's abuse of privileged information, in which a reviewer or an associate, who is likely to be a competitor, directs members of their laboratory to rapidly replicate the data and submit the resulting paper in the same or another journal while delaying publication of the submitted paper; (2) defective micromanagement by a stakeholder or owner, such as failure to order paper for the publication of a journal; (3) penny-wise dollar-foolish mismanagement by the owner, such as limiting the figures allowed to an absurdly low number in a dermatology journal (we have a visual specialty); (4) factional abuse, such as when members of a society use a gimmick to exercise outsized influence to effect a change in journal's content, and (5) " (who is in charge)?," in which changes in the governance of an ownership society or publisher affect quality of the journal.

View Article and Find Full Text PDF

Background: Race- and ethnicity-based differences in treatment access and outcomes have been reported in the orthopaedic sports medicine literature. However, the rate at which race and ethnicity are reported and incorporated into the statistical analysis of sports medicine studies remains unclear.

Purpose: To determine the rate at which race and ethnicity are reported and analyzed in athlete-specific sports medicine literature.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the shear wave velocity (SWV) of key foot structures (posterior tibial tendon, deltoid ligament, and spring ligament) in relation to progressive collapsing foot deformity.
  • The researchers measured SWV in 20 patients with varying foot conditions (neutral, asymptomatic flatfeet, and symptomatic flatfeet) under different stress conditions.
  • Findings indicate lower SWV in symptomatic flatfeet compared to normal ones, suggesting that SWV could help assess foot structure degeneration, but more research is needed for clinical use.*
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to investigate the symptoms and clinical exam findings in patients who underwent meniscal root repairs, which can help physicians accurately diagnose this specific injury.
  • Researchers reviewed clinical notes from 221 patients (aged 40 and above) who had isolated arthroscopic meniscal root repairs, focusing on initial symptoms, physical examination results, and radiographic grading for osteoarthritis and root tears.
  • Key findings included that most patients experienced pain after an acute injury, with common signs like knee effusion, positive McMurray tests, and positive hyperflexion tests observed in those with meniscal root tears.
View Article and Find Full Text PDF

AGREE II Evaluation of Clinical Practice Guidelines on Generalized Cancer Pain Management.

Pain Manag Nurs

October 2024

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA. Electronic address:

Purpose: While several clinical practice guidelines (CPGs) exist to guide clinical decision-making in patients with generalized cancer pain, to date there has been no comprehensive review of their quality. Our aim was to address this deficiency via the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool.

Design: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline-based systematic literature search followed by AGREE II appraisal of identified CPGs.

View Article and Find Full Text PDF

Commemoration of seven accomplished Jewish women in dermatology from Europe and Canada.

Clin Dermatol

October 2024

Department of Dermatology, University of Connecticut School of Medicine Farmington, Connecticut, USA; Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida, USA. Electronic address:

Article Synopsis
  • The text honors seven influential European and Canadian Jewish women who made significant contributions to dermatology and faced numerous challenges in their careers.
  • These pioneering dermatologists demonstrated exceptional courage in overcoming professional barriers and combating antisemitism, particularly during times of Nazi oppression.
  • The highlighted individuals are Lili Farkas, Vera Shukhman, Stefania Jablonska, Halina Szenicer-Rotstein, Fanny Cohn, Marie Caroline Kaufmann-Wolf, and Rickey Kanee Schachter, each recognized for their remarkable achievements in the field.
View Article and Find Full Text PDF

Oscar Samuel Hoffman (1856-1926) was the first Jewish physician to settle in Omaha, Nebraska in 1883. He taught dermatology for 25 years at the Omaha Medical College and University of Nebraska, after completing postgraduate work in Vienna under the noted dermatologist Moritz Kaposi (1837-1902). His expertise also included obstetrics, and he became the Professor of Obstetrics and Dermatology at Omaha Medical College.

View Article and Find Full Text PDF
Article Synopsis
  • Recent research indicates that negative-pressure wound therapy (NPWT) can effectively extend the time before surgical coverage is needed for traumatic extremity injuries, challenging the traditional 72-hour guideline for flap reconstruction.
  • A study reviewed 24 articles involving over 1,000 patients, comparing outcomes between those who received NPWT preoperatively and those who did not, finding that NPWT was linked to significantly lower rates of flap failure and postoperative complications, except for deep infections.
  • The findings suggest that using NPWT can improve surgical outcomes, highlighting the need for more standardized future studies to further refine treatment protocols for extremity injuries.
View Article and Find Full Text PDF

Curriculum Innovation: Design and Implementation of Synchronous and Asynchronous Curricula to Enhance Residents' EEG Knowledge and Experience.

Neurol Educ

December 2023

From the Department of Neurology (A.F.), Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Department of Neurology (J.J.M.), Yale School of Medicine, New Haven, CT; Department of Neurology (D.B.H.), Children's National Medical Center, Washington, DC; Department of Neurology (R.M.G.), Washington University School of Medicine and St. Louis Childrens Hospital, MO; Department of Neurology (J.P.), University of Pennsylvania, Philadelphia; Minnesota Epilepsy Group, P.A. (N.A., K.S.), Roseville, MN; Division of Pediatric Neurology (J.M.C.), Connecticut Childrens, University of Connecticut School of Medicine, Hartford, CT; American Epilepsy Society (A.K.), Chicago, IL; Department of Neurology (F.A.L.), Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY; and Department of Neurology (D.J.W.), St. Louis University, MO.

Introduction And Problem Statement: There is a need for structured EEG education opportunities to enhance neurology resident education. To address this need, the American Epilepsy Society (AES) supported the development and implementation of both synchronous and asynchronous EEG courses.

Objectives: To produce EEG curricula that enhance resident EEG learning, increase interest in EEG and improve participants' knowledge, and to ensure that courses were highly used and available to the broadest range of learners.

View Article and Find Full Text PDF