Migration of total petroleum hydrocarbon and heavy metal contaminants in the soil-groundwater interface of a petrochemical site using machine learning: impacts of convection and diffusion.

Convection and diffusion are key pathways for the migration of total petroleum hydrocarbons (TPH) and heavy metals (HMs) from soil to groundwater. However, the extent of their influence on pollutant migration, as well as the nonlinear relationships between these processes and pollutants, remains unclear. This study investigates the spatial distribution of TPH and HMs at a petrochemical site with complex hydrogeological conditions in southwestern China.

A GALNT3 mutation causing Hyperphosphatemic familial Tumoral calcinosis.

Unlabelled: Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) is an autosomal recessive disorder. This study investigates the etiology of HFTC in offspring from consanguineous parents.

Methods: Clinical assessment, imaging, and direct sequencing were utilized to elucidate the condition.

Stroke volume variation induced by lung recruitment maneuver to predict fluid responsiveness in patients receiving mechanical ventilation: A systematic review and meta-analysis.

Study Objective: The aim of this study was to evaluate the accuracy of lung recruitment maneuver induced stroke volume variation (ΔSV) in predicting fluid responsiveness in mechanically ventilated adult patients by systematic review and meta-analysis.

Methods: A comprehensive electronic search of relevant literature was conducted in PubMed, Web of Science, Cochrane Library, Ovid Medline, Embase and Chinese databases (including China National Knowledge Infrastructure, Wanfang and VIP databases). Review Manager 5.

Restraining the shuttle effect of polyiodides and modulating the deposition of zinc ions to enhance the cycle lifespan of aqueous Zn-I batteries.

The boom of aqueous Zn-based energy storage devices, such as zinc-iodine (Zn-I) batteries, is quite suitable for safe and sustainable energy storage technologies. However, in rechargeable aqueous Zn-I batteries, the shuttle phenomenon of polyiodide ions usually leads to irreversible capacity loss resulting from both the iodine cathode and the zinc anode, and thus impinges on the cycle lifespan of the battery. Herein, a nontoxic, biocompatible, and economical polymer of polyvinyl alcohol (PVA) is exploited as an electrolyte additive.

Multi-omics Mendelian randomization integrating GWAS, eQTL, and mQTL data identified genes associated with breast cancer.

Breast cancer (BC) remains a major disease posing a threat to women's health, but the underlying biological interpretation remains largely unknown. Here, we aimed to identify genes associated with breast cancer and analyze their pathophysiological mechanisms based on multi-omics Mendelian randomization (MR). Summary-data-based MR (SMR) was performed to estimate the causal effects of blood and breast mammary tissue expression quantitative trait loci (eQTLs) on BC.

Selective Stereoretention of Carbohydrates upon C-C Cleavage Enabling D-Glyceric Acid Production with High Optical Purity over a Ag/γ-AlO Catalyst.

Chiral carboxylic acid production from renewable biomass by chemocatalysis is vitally important for reducing our carbon footprint, but remains underdeveloped. We herein establish a strategy that make use of a stereogenic center of biomass to achieve a rare example of D-glyceric acid production with the highest yield (86.8 %) reported to date as well as an excellent ee value (>99 %).

Experimental treatment efficacy of dmrFABP5 on prostate cancer singly or in combination with drugs in use.

Enzalutamide is a drug used to treat prostate cancer (PC) and docetaxel is a drug for chemotherapeutic treatment of diverse cancer types, including PC. The effectiveness of these drugs in treating castration-resistant prostate cancer (CRPC) is poor and therefore CRPC is still largely incurable. However, the bio-inhibitor of fatty acid-binding protein 5 (FABP5), dmrFABP5, which is a mutant form of FABP5 incapable of binding to fatty acids, has been shown recently to be able to suppress the tumorigenicity and metastasis of cultured CRPC cells.

Insights into the potential applications of permanganate/peroxymonosulfate systems: enhancement amorphous MnO, effects of water matrices, and optimization using response surface methodology.

In this study, we developed a novel self-catalytic oxidation system involving peroxymonosulfate (PMS) and permanganate (KMnO), named as CUPP, to efficiently mineralize sulfamethoxazole (SMX) in groundwater. It was found that amorphous MnO derived from the reduction of KMnO can directly adsorb HSO, a complex hydroxyl group, mediate the internal disproportionation reaction of HSO with the manganese complex, and effectively activate PMS, thereby promoting the oxidation of SMX and its degradation intermediates through sulfonate radiation. Furthermore, by using electron spin resonance (EPR), HPLC/MS full scan, and response surface methodology, the coexistence of HO˙, SO˙, O˙, O, and active chlorine (Cl, HOCl) in the CUPP system was confirmed.

Minimally invasive versus abdominal radical trachelectomy for early-stage cervical cancer: a systematic review and meta-analysis.

The safety of minimally invasive surgery (MIS) for cervical cancer has been questioned. This systematic review and meta-analysis aimed to compare the clinical outcomes of patients with cervical cancer who underwent MIS and abdominal trachelectomy. We searched for and subsequently analyzed studies published in PubMed, Embase, Cochrane Central Register of Controlled Trials, International Clinical Trials Registry Platform, and Clinical Trials.

Incidence and risk factors for venous thromboembolism in patients with ovarian cancer during neoadjuvant chemotherapy: a meta-analysis.

In recent years, there has been increasing recognition of the relationship between neoadjuvant chemotherapy (NACT) in ovarian cancer and the incidence rate of venous thromboembolism (VTE). Some studies have suggested that NACT may be associated with a high risk of VTE in patients with ovarian cancer. To investigate this, we conducted a systematic review and meta-analysis of the incidence of VTE during NACT and its associated risk factors.

Pay-it-forward to increase uptake among 15-18-year-old adolescent girls compared with user-paid vaccination: The pilot results of a two-arm randomized controlled trial in China.

Background: China has low human papillomavirus(HPV) vaccination rate due to lack of public funding and mistrust in domestic vaccines. This pilot study evaluated the feasibility and preliminary effectiveness of an innovative pay-it-forward strategy, which has a participant receive a subsidized vaccine and offers her an opportunity to donate to support other girls, in improving HPV vaccine uptake among 15-18-year-old adolescent girls.

Methods: A two-arm randomized controlled pilot trial was performed in one vaccination clinic in Western China.

Study on the preparation of Interleukin 8 loaded hydrogel fiber and regulation on recruitment of stem cells.

The high wastage rate and low survival rate of seed cells in conventional bone tissue engineering (BTE) are always a challenge for tissue regeneration. Constructing scaffolds that could continuously recruit endogenous stem cells is considered a novel way to promote tissue repair. In this study, a GelMA fiber hydrogel membrane loaded interleukin 8 (IL8) (IL8-GelMA), was prepared via electrostatic spinning technology.

Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review.

In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the penetration of a cell membrane. In this regard, several studies have focused on methods to produce nanorods and nanotubes with controlled optimized size and aspect ratio (AR).

Effect of polyacrylamide morphology templated using lyotropic liquid crystal on the proton conductivity of acid hydrogels.

Acid hydrogels comprising polymer networks are promising soft electrolytes whose proton conductivities are most often regulated by acid content. Herein, promotion of conductivity by solely regulating polymer morphology has been demonstrated for acid hydrogels with identical acid content. Polymerization of acrylamide at different temperatures in the same aqueous solution, which is a lyotropic liquid crystal (LLC) of 4-(1-ethyldecyl)benzenesulfonic acid (EDBSA) exhibiting a phase transition at 30 °C, affords acid hydrogels comprising ordered and random polymer networks.

A novel potential mechanism for the development of portal vein thrombosis in cirrhosis based on portal hemodynamics.

Background: Marked changes in hemodynamics have been suggested to be a potential contributing factor to portal vein thrombosis (PVT) development. This study investigated the effect of portal hemodynamics based on the anatomical structure of the portal venous system on PVT development.

Methods: The morphological features of portal venous system in patients with PVT and those without PVT subgroups were compared.

Synergies in antimicrobial treatment by a levofloxacin-loaded halloysite and gold nanoparticles with a conjugation to a cell-penetrating peptide.

Herein, a novel designed antimicrobial therapeutic drug delivery system is presented, in which halloysite nanotubes (HNTs) encapsulate a determined dosage of levofloxacin (lvx). Moreover, gold nanoparticles (AuNPs) have been embedded into the structure for plasmonic heating under irradiation of the green LED light (7 W, 526 nm). It was revealed that the plasmonic heating of the AuNPs leads to a controlled trend in the lvx release process.

Clinical outcome of lymphadenectomy in malignant ovarian germ cell tumors: a systematic review and meta-analysis.

Malignant ovarian germ cell tumors (MOGCTs) are predominately diagnosed in young patients and account for most preadolescent malignant ovarian tumors. Currently, due to the high sensitivity of MOGCTs to chemotherapy and the optimal survival rate after chemotherapy, some researchers have recommended opting for non-surgical treatment. However, the effect of lymphadenectomy (LND) on the survival of patients with MOGCT remains controversial.

Relapses after SARS-CoV-2 vaccination in patients with neuromyelitis optica spectrum disorder and multiple sclerosis.

Background: The COVID-19 pandemic outbreak raises the question of whether immunization is recommended for patients with CNS demyelinating diseases. On the one hand, existing studies suggested that SARS-CoV-2 vaccinations are not associated with increased risk of relapse activity. On the other hand, case reports with acute CNS demyelinating disease post vaccination were emerging and raising clinicians' attention.

Cementless curved endoprosthesis stem for distal femoral reconstruction in a Chinese population: a combined anatomical & biomechanical study.

Background: The endoprosthetic knee reconstruction using a current universal femoral stem might not be suitable for local population due to the anatomical difference between Chinese and Western populations. We measured the anatomical parameters of Chinese femurs as reference for stem design, and proposed a cementless, curved, short endoprosthesis stem for the reconstruction of distal femur. This study analyzed the biomechanical performance of the newly designed stem aimed at the identification of better operative strategy.

Patient-controlled intravenous analgesia with opioids after thoracoscopic lung surgery: a randomized clinical trial.

Background: Opioids remain the mainstream therapy for post-surgical pain. The choice of opioids administered by patient-controlled intravenous analgesia (PCIA) for thoracoscopic lung surgery is unclear. This study compared 3 opioid analgesics for achieving satisfactory analgesia with minimal emesis (SAME).

Posterior two-step distraction and reduction for basilar invagination with atlantoaxial dislocation: a novel technique for precise control of reduction degree without traction.

Purpose: The pathological changes of basilar invagination (BI) and atlantoaxial dislocation (AAD) include vertical and horizontal dislocations. Current surgical techniques have difficulty in accurately controlling the degree of reduction in these two directions and often require preoperative traction, which increases patients' pain, hospital stay, and medical cost. This study aimed to introduce a novel technique for accurately reducing horizontal and vertical dislocation without preoperative traction and report the radiological and clinical outcomes.

Monoammonium salts of multiprotic acids as dopants for proton-conductive hydrogel membranes: the effects of anions.

Monoammonium salts of diprotic acid (NHHSO) and triprotic acid (NHHPO), whose cations and anions are both potential proton carriers, were employed as dopants for proton-conductive hydrogel membranes to explore the effects of anions on thermal, mechanical, and electrochemical performance. Robust hydrogel membranes were obtained by radical copolymerization of acrylamide and ethylene glycol dimethacrylate dissolved in aqueous solutions of NHHSO and NHHPO. By virtue of the protonated ammonium cation, the ionic conductivities of the hydrogels doped with NHHSO and NHHPO were superior to those doped with the corresponding inorganic acids (HSO and HPO).

One-step coordination of metal-phenolic networks as antibacterial coatings with sustainable and controllable copper release for urinary catheter applications.

Catheter-associated urinary tract infections (CAUTIs) draw great concern due to increased demand for urinary catheters in hospitalization. Encrustation caused by urinary pathogens, especially , results in blocking of the catheter lumen and further infections. In this study, a facile and low-cost surface modification strategy of urinary catheters was developed using one-step coordination of tannic acid (TA) and copper ions.

gelation of aqueous sulfuric acid solution for fuel cells.

Aqueous sulfuric acid solution is a versatile liquid electrolyte for electrochemical applications and gelation of it has the advantages of easy shaping and reduced leaking. Herein, aqueous sulfuric acid solutions with concentrations of 1-4 mol L are fabricated into gel membranes by polymerization of acrylamide as a monomer and divilynbenzene as a crosslinker for fuel cell applications. The gel membrane with an acid concentration of 3.