Relationship between polymorphisms of CXCL3 gene and preeclampsia.

Background: Preeclampsia (PE), a pregnancy-specific disease, is a main cause of maternal and perinatal mortality in the world, the exact pathogenesis of which is still unknown. Recent studies have found it is a disorder caused by multiple factors and genes. Previously, we found a significantly abnormal expression of CXCL3 in plasma and placenta of severe preeclampsia.

Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer.

Introduction: The efficacy of chemotherapeutic agents in killing cancer cells is mainly attributed to the induction of apoptosis. However, the tremendous efforts on enhancing apoptosis-related mechanisms have only moderately improved lung cancer chemotherapy, suggesting that other cell death mechanisms such as necroptosis could be involved. In this study, we investigated the role of the necroptosis pathway in the responsiveness of nonsmall cell lung cancer (NSCLC) to chemotherapy.

Associations between nocturnal sleep duration, midday nap duration and body composition among adults in Southwest China.

Objective: We aim to explore the relationship between nocturnal sleep duration (NSD) and midday nap duration (MND) with body composition among Southwest Chinese adults.

Methods: Data on sleep duration of 3145 adults in Southwest China (59.4% women) were obtained between 2014 and 2015 through questionnaires.

CircHIPK3 is decreased in preeclampsia and affects migration, invasion, proliferation, and tube formation of human trophoblast cells.

Introduction: The migration and invasion of trophoblast cells into the endometrium and vasculature is a key step in human placentation. Preeclampsia, a devastating multi-system syndrome, is featured by shallow trophoblast invasion and unconverted narrow spiral arteries. Although the alteration in circHIPK3 expression is proved to regulate the invasion and metastasis of various malignant cells, its role in preeclampsia is unknown.

Systematic review of the effects of birth spacing after cesarean delivery on maternal and perinatal outcomes.

Background: Little is known about the association between birth spacing and subsequent pregnancy outcomes after cesarean delivery.

Objectives: To summarize the effects of birth spacing after previous caesarean on maternal and perinatal outcomes.

Search Strategy: Four online databases were searched via a multistage search strategy.

Association between RUNX3 gene polymorphisms in severe preeclampsia and its clinical features.

Preeclampsia is a complex genetic disorder and its pathogenesis remains to be investigated. Single nucleotide polymorphisms serve important roles in genetic predisposition. The present study aimed to explore the association between runt-related transcription factor 3 (RUNX3) gene polymorphisms in severe preeclampsia (SPE) and clinical features.

Association between polymorphisms in CXCR2 gene and preeclampsia.

Background: Preeclampsia is a serious pregnancy-specific syndrome with incompletely understood pathogenesis. Previous study has demonstrated that the decreased CXCR2 in preeclamptic placentas may contribute to the development of preeclampsia. The role of single nucleotide polymorphisms (SNPs) of CXCR2 gene in the pathogenesis of preeclampsia remains largely unexplored.

Factors affecting labor duration in Chinese pregnant women.

The aim of the study was to explore the role of parity, maternal age, medical interventions, and birth weight with respect to labor duration and cervical dilation.A total of 1601 pregnant women who had a singleton term gestation, spontaneous onset of labor, vertex presentation, vaginal delivery, and a normal perinatal outcome were reviewed. The retrospective study was conducted in patients from West China Second University Hospital of Sichuan University during June 2008 to June 2013.

Population genetic analysis of 30 insertion-deletion (INDEL) loci in a Qinghai Tibetan group using the Investigator DIPplex Kit.

The Qiagen Investigator® DIPplex Kit multiplexes 30 autosomal INDELs plus amelogenin for forensic use. The aim of this study was to estimate the diversity of 30 INDEL loci in a sample of 530 Tibetan individuals from Qinghai Province, China, and to evaluate the usefulness of these loci for forensic genetics. The observed heterozygosity ranged from 14.

Two-person DNA mixture interpretation based on a novel set of SNP-STR markers.

Autosomal short tandem repeats (STR) markers analysed by PCR and capillary electrophoresis (CE) represent the gold-standard for forensic DNA analysis. With the improved sensitivity of detection equipment, a larger number of mixed DNA profiles can be obtained from trace amounts of DNA that conventionally used to appear as a single source. More specifically, two-source DNA mixtures, comprising the victim's and the perpetrator's DNAs, are often encountered in forensic casework, where the victim's DNA represents a major component of the mixture.

Luteolin and sorafenib combination kills human hepatocellular carcinoma cells through apoptosis potentiation and JNK activation.

Sorafenib is a small-molecule multi-kinase inhibitor approved by FDA as an oral agent for the treatment of hepatocellular carcinoma (HCC) and renal cell carcinoma. However, unresponsiveness and acquired resistance are commonly observed, which hinder the clinical use of sorafenib. As combination therapy is a promising approach to improve its efficacy, we investigated if sorafenib and luteolin combination is effective in killing human HCC cells.

Monetary diet cost is positively associated with diet quality and obesity: an analysis of school-aged children in Southwest China.

Background: Little is known about the relationships between diet cost, dietary intake and obesity in Chinese populations. This study explored how diet cost was related to diet quality and obesity among school-aged children in Southwest China.

Methods: Data from a cross-sectional study was analysed.

Effects of CXCL3 on migration, invasion, proliferation and tube formation of trophoblast cells.

CXCL3 was reportedly associated with the invasion and metastasis of various malignancies, the role of CXCL3, however, in preeclampsia has not been fully discussed. We previously found placental CXCL3 level in severe preeclampsia was significantly lower than that in healthy pregnancy and exogenous recombinant human CXCL3 protein was able to promote trophoblasts' migration and proliferation. The current study, therefore, is further to investigate effects of endogenous CXCL3 on migration, invasion, proliferation, tube formation and apoptosis of trophoblasts.

Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade.

While chromatin remodeling mediated by post-translational modification of histone is extensively studied in carcinogenesis and cancer cell's response to chemotherapy and radiotherapy, little is known about the role of histone expression in chemoresistance. Here we report a novel chemoresistance mechanism involving histone H4 expression. Extended from our previous studies showing that concurrent blockage of the NF-κB and Akt signaling pathways sensitizes lung cancer cells to cisplatin-induced apoptosis, we for the first time found that knockdown of Akt1 and the NF-κB-activating kinase IKKβ cooperatively downregulated histone H4 expression, which increased cisplatin-induced apoptosis in lung cancer cells.

Down-regulated long non-coding RNA-ATB in preeclampsia and its effect on suppressing migration, proliferation, and tube formation of trophoblast cells.

Preeclampsia is a pregnancy-specific syndrome and is one of the main causes of maternal, fetal, and neonatal morbidity and mortality. Inadequate trophoblast invasion and failure of uterine spiral artery remodeling exert a major role in the development of preeclampsia, especially the early-onset one. LncRNA-ATB is verified to be aberrantly expressed in many cancers and promote the invasion-metastasis and proliferation cascades.

Reversal of multidrug resistance in vitro and in vivo by 5-N-formylardeemin, a new ardeemin derivative.

Because multidrug resistance (MDR) is a serious impediment to the use of chemotherapy in treating cancer patients, great efforts have been made to search for effective MDR-reversing agents. We have developed a brand new synthetic ardeemin derivative, 5-N-formylardeemin, and investigated the activity of which in reversing MDR in MDR cancer cell lines derived from human breast cancer (MCF-7-R) or lung cancer (A549-R). 5-N-formylardeemin strongly enhanced the anti-cancer efficacy of doxorubicin, vincristine through potentiation of apoptosis in both MCF-7-R and A549-R at relatively noncytotoxic concentrations in vitro.