Correction: Multiple pH responsive zwitterionic micelles for stealth delivery of anticancer drugs.

[This corrects the article DOI: 10.1039/C6RA11645K.].

Fano enhancement of SERS for rapid early diagnosis of colorectal cancer.

Patients benefit greatly from early detection of colorectal cancer, but present diagnostic procedures have high costs, low sensitivity, and low specificity. However, it is still difficult to develop a strategy that can effectively detect cancer early using high-throughput blood analysis. Fano resonance-boosted SERS platform label-free serum creates an effective diagnostic system at the point of care.

The Association of Retinal Microvasculature With Gray Matter Changes and Structural Covariance Network: A Voxel-Based Morphometry Study.

Purpose: Increasing evidence suggests that retinal microvasculature may reflect global cerebral atrophy. However, little is known about the relation of retinal microvasculature with specific brain regions and brain networks. Therefore, we aimed to unravel the association of retinal microvasculature with gray matter changes and structural covariance network using a voxel-based morphometry (VBM) analysis.

Photopolymerized poly(l-lactide--vinyl-2-pyrrolidone) network resists cell adhesion .

A three-armed star-shaped poly(l-lactide) (PLLA) oligomer was synthesized using glycerol to ring-opening and polymerize l-lactide. The resultant oligomer introduced photoreactive groups at the terminal of PLLA chains by a coupling reaction with monoethyl fumarate (FAME). Photopolymerizable resin has been prepared by mixing PLLA 3-FAME, -vinyl-2-pyrrolidone (NVP) as a reactive diluent and Irgacure 2959 as a photoinitiator.

Preparation and characterization of photopolymerized poly(l-lactide--ε-caprolactone--vinyl-2-pyrrolidone) network as anti-biofouling materials.

The anti-biofouling properties have important applications in the medical field. In this study, cross-linked networks were prepared by photopolymerizing two synthetic macromonomers, including fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(l-lactide) prepolymers (3-PLLA-F) and poly(ε-caprolactone) prepolymers (2-PCL-F), with -vinyl-2-pyrrolidone (NVP) as the diluent. The prepared networks were characterized by their thermal properties, mechanical properties, cytotoxicity experiments and anti-biofouling properties.

A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i).

The disruption of copper homeostasis (Cu/Cu) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu in physiological and pathological processes prompted the development of improved methods of Cu analysis. Herein, a new near-infrared (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu was developed based on a Cu-mediated benzylic ether bond cleavage mechanism.

Development of pathological reconstructed high-resolution images using artificial intelligence based on whole slide image.

Pathology plays a very important role in cancer diagnosis. The rapid development of digital pathology (DP) based on whole slide image (WSI) has led to many improvements in computer-assisted diagnosis by artificial intelligence. The common digitization strategy is to scan the pathology slice with 20× or 40× objective, and the 40× objective requires excessive storage space and transmission time, which are significant negative factors in the popularization of DP.

Accessibility of automatic external defibrillators and survival rate of people with out-of-hospital cardiac arrest: A systematic review of real-world studies.

Objective: To evaluate the relationship between the accessibility of automatic external defibrillators (AEDs) and the survival rate of patients who have out-of-hospital cardiac arrest (OHCA).

Methods: The systematic review was conducted according to the Cochrane Handbook of Systematic Reviews. We searched the Chinese and English literature databases from 2009 to 2019.

The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties.

Porous β-tricalcium phosphate (β-Ca(PO), β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their clinical application. In order to address these disadvantages, graphene (G) and silver nanoparticles were introduced into β-TCP through a two-step method.

Unleashing the role of top management and government support in green supply chain management and sustainable development goals.

Achievement of Sustainable Development Goals (SDGs) has become one of the most important goals across the globe due to their significant role in the economic prosperity and human well-being. Recently, the business industry has become a dominant concentration for SDGs. However, the importance of small- and medium-sized industries has been rarely debated in this perspective.

polysaccharide induced apoptosis and inhibited proliferation in infantile hemangioma endothelial cells via down-regulation of PI3K/AKT signaling pathway.

polysaccharide (LBP) has a variety of pharmacological and biological activities such as anti-inflammatory, antioxidation, anti-apoptosis, immune regulation and other pharmacological effects; however, the effect of LBP on infantile hemangioma (IH) was less reported. Primary human hemangioma endothelial cells (HemECs) were isolated from fresh surgical specimens of patients. HemECs was treated with LBP and the changes in proliferative and apoptotic signaling pathways were investigated by performing cell counting kit-8, cloning formation experiment, angiogenesis experiment, flow cytometry, Western blot, immunofluorescence, HE stain and real-time quantitative polymerase chain reaction.

What makes cells move: Requirements and obstacles for leader cells in collective invasion.

Most recently, mounting evidence has shown that cancer cells can invade as a cohesive and multicellular group with coordinated movement, which is called collective invasion. In this cohesive cancer cell group, cancer cells at the front of collective invasion are defined as leader cell that are responsible for many aspects of collective invasion, including sensing the microenvironment, determining the invasion direction, modifying the path of invasion and transmitting information to other cells. To fulfill their dispensable roles, leader cells are required to embark on some specific phenotypes with unusual expression of some proteins and it's very important to investigate into these proteins as they may serve as potential therapeutic targets.

Antibacterial coordination polymer hydrogels composed of silver(i)-PEGylated bisimidazolylbenzyl alcohol.

Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a-c). These coordination polymer hydrogels exhibit much better antibacterial activity than silver nitrate against both Gram-negative and Gram-positive pathogens including multidrug-resistant pathogens. The coordination polymer Ag/1c with a long PEG chain (PEG1000) was demonstrated to be the most effective antibacterial material, and its minimum inhibition concentrations (MICs) could be as low as 15.

Synergistic effect of CB and GO/CNT hybrid fillers on the mechanical properties and fatigue behavior of NR composites.

In this paper, graphene oxide (GO) and carbon nanotube (CNT) hybrid fillers were used to replace partial carbon black (CB), and GO/CNT/CB/NR composites were prepared with excellent crack growth resistance, low heat build-up and superior mechanical properties. Mechanical testing revealed a significant synergistic reinforcement between GO/CNT and CB in NR composites. The improved dispersion of GO/CNT hybrid fillers and CB in the NR matrix was characterized by transmission electron microscopy (TEM).

Leptin can promote mineralization and up-regulate RANKL mRNA expression in osteoblasts from adult female SD rats.

Osteoblast-related bone formation is an indispensable part of bone remodeling. Osteoblasts can regulate osteoclast activity through the OPG/RANK/RANKL system. Therefore, studies focus on osteoblast proliferation, differentiation, mineralization, and regulation of osteoclasto genes are important.

Short- and Long-term Outcomes between Young and Older HCC Patients Exceeding The Milan Criteria after Hepatectomy.

Aim: The objective of this study was to evaluate short- and long-term survival after surgical treatment between young and older hepatocellular carcinoma (HCC) patients beyond the Milan criteria.

Material And Methods: One hundred fifty-seven HCC patients (≤ 55 years old) were categorized into group A, and one hundred fifty-eight HCC patients (> 55 years old) were categorized into group B. Postoperative complications and overall survival were retrospectively analyzed.

Paragonimiasis in Children in Southwest China: A retrospective case reports review from 2005 to 2016.

Background: Paragonimiasis infection has no specific symptoms or typical radiologic findings, leading to the possibility of misdiagnosis. Thus, the objective of this study was to analyze clinical and radiological features, and treatment outcome of paragonimiasis in children in Southwest China to improve the awareness of this disease.

Methods: We retrospectively reviewed the records of children diagnosed with paragonimiasis in West China Second University Hospital between 2005 and 2016.

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substrates.

Benign fibrous histiocytoma of the fronto-temporo-parietal region: a case report and review of the literature.

Primary benign fibrous histiocytoma (BFH) at the skull is extremely rare. Here we report a case of a 22-year-old man presented with a 1-year history of progressive enlargement subcutaneous mass on the right side of the fronto-temporo-parietal region without symptoms. The tumor was radical resected through craniotomy and the bone defect was repaired by pre-plasticity titanium mesh.

Association between the COMT 158 G/A polymorphism and lung cancer risk: a meta-analysis.

Catechol-O-methyltransferase (COMT) 158 G/A gene polymorphism seem to associate with lung cancer, but the results are inconclusive. This meta-analysis aims to investigate the association between COMT 158 G/A gene polymorphism and lung cancer susceptibility. We searched PubMed, Embase, China National Knowledge Infrastructure (CNKI), VIP Chinese science and technology periodical database (VIP) and Wanfang databases up to March 25, 2015 for articles on the connection between the COMT 158 G/A polymorphism and the risk of lung cancer.

Association between interluekin-17 gene polymorphisms and the risk of cervical cancer in a Chinese population.

We conducted a study to analyze the association of three common SNPs of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 gene polymorphisms with the risk of cervical cancer in a Chinese population. Our study included 352 cervical cancer patients and 352 controls between January 2013 and December 2014. Genotyping of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 genes was performed by multiplex PCR assays using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Rapid progressive interstitial lung disease as initial manifestation of primary Sjögren's syndrome: a case report.

Primary Sjögren's syndrome is a chronic inflammatory disorder with many extraglandular organ systems involved, including the lungs. Diffuse interstitial lung disease is the most serious form of lung involvement. Parenchymal lung involvement in primary Sjögren's syndrome is usually manifested by cough and/or slowly progressive dyspnea and most of the cases present as chronic course.

Fixed nuclei as alternative template of BIOMED-2 multiplex polymerase chain reaction for immunoglobulin gene clonality testing in B-cell malignancies.

Evaluation of immunoglobulin (Ig) gene rearrangements with BIOMED-2 multiplex PCR has become a standard detection of clonality in mature B cell malignancies. Conventionally, this method is relatively labor-intensive and time-consuming, as it requires DNA isolation from bone marrow aspirates (BM) or peripheral blood (PB) in patients with BM or PB involvement. On the other hand, fluorescence in situ hybridization (FISH) is routinely used as genetic screening in B cell malignancies, but the surplus fixed nuclei initially prepared for FISH usually turn useless afterwards.