4 results match your criteria: "Sichuan University Chengdu People's Republic of China.[Affiliation]"
Isoxanthohumol improves hepatic lipid metabolism via regulating the AMPK/PPARα and PI3K/AKT signaling pathways in hyperlipidemic mice.
Food Sci Nutr
November 2024
West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Natural and Biomimetic Medicine Research Center, Tissue-Orientated Property of Chinese Medicine Key Laboratory of Sichuan Province, West China School of Medicine West China Hospital, Sichuan University Chengdu People's Republic of China.
Article Synopsis
- Hyperlipidemia is a major global health issue that requires new treatment strategies, and moderate beer consumption may provide benefits due to its flavonoid, isoxanthohumol (IXN).
- Research using a mouse model of acute hyperlipidemia showed that IXN improved blood lipid levels and reduced liver fat, as indicated by biochemical and histological analyses.
- IXN works by activating key signaling pathways related to lipid metabolism, specifically the AMPK/PPARα and PI3K/AKT pathways, which help reduce lipid accumulation and oxidative stress.
Long-Term Durability of Transcatheter Aortic Valve Prostheses in Patients With Bicuspid Versus Tricuspid Aortic Valve.
J Am Heart Assoc
November 2024
Department of Cardiology West China Hospital, Sichuan University Chengdu People's Republic of China.
Article Synopsis
- This study investigates the long-term durability of bioprosthetic valves in patients with bicuspid aortic valve (BAV) after undergoing transcatheter aortic valve replacement (TAVR), compared to patients with tricuspid aortic valve (TAV).
- A total of 170 BAV and 145 TAV patients were followed for an average of over 5 years, showing no significant differences in rates of structural valve deterioration or bioprosthetic valve failure between the two groups.
- The findings suggest that TAVR provides satisfactory long-term valve performance for patients with BAV, comparable to those with TAV, indicating good outcomes for both groups.
Current landscape of gene-editing technology in biomedicine: Applications, advantages, challenges, and perspectives.
MedComm (2020)
September 2022
The expanding genome editing toolbox has revolutionized life science research ranging from the bench to the bedside. These "molecular scissors" have offered us unprecedented abilities to manipulate nucleic acid sequences precisely in living cells from diverse species. Continued advances in genome editing exponentially broaden our knowledge of human genetics, epigenetics, molecular biology, and pathology.
View Article and Find Full Text PDFThe optimal dosing regimen of tranexamic acid (TXA) has not been determined in total knee arthroplasty (TKA). In this study, patients were randomized to receive a high initial-dose (60 mg/kg) TXA before incision, followed by five doses 3, 6, 12, 18, and 24 hours later (A), or three doses 3, 12, and 24 hours later (B), or a single dose 3 hours later (C). The primary outcome was perioperative blood loss.
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