Rh-catalyzed regio-switchable cross-coupling of -difluorinated cyclopropanes with allylboronates to structurally diverse fluorinated dienes.

The control of linear/branched selectivity is one of the major focuses in transition-metal catalyzed allyl-allyl cross-coupling reactions, in which bond connection occurs at the terminal site of both the allyl fragments forming different types of 1,5-dienes. Herein, terminal/internal regioselectivity is investigated and found to be switchable in allyl-allyl cross-coupling reactions between -difluorinated cyclopropanes and allylboronates. The controlled terminal/internal regioselectivity arises from the fine-tuning of the rhodium catalytic system.