The mediating effect of self-efficacy and physical activity with the moderating effect of social support on the relationship between negative body image and depression among Chinese college students: a cross-sectional study.

Background: Fitness to maintain an ideal body shape is becoming increasingly popular among college students. However, it also leads to many mental health issues. This study explores the pathways through which negative body image affects depression in college students.

Strains of a virtuoso: pacemaker infection and ventricular tachycardia in a violinist.

Purpose: Pacemaker-related infections are serious complications of cardiac implantable electronic devices (CIEDs). This case report aims to describe the occurrence of pacemaker pocket infection and recurrent ventricular tachycardia (VT) in a Chinese amateur violinist with sick sinus syndrome (SSS), and to explore the possible connection between occupational habits and the infection, as well as VT.

Methods: A 76-year-old male violinist with a Biotronik Evia DR dual-chamber pacemaker presented with syncope and signs of a pacemaker pocket infection three years after implantation.

Liquid biopsy technologies: innovations and future directions in breast cancer biomarker detection.

Globally, breast cancer is the most frequent type of cancer, and its early diagnosis and screening can significantly improve the probability of survival and quality of life of those affected. Liquid biopsy-based targets such as circulating tumor cells, circulating tumor DNA, and exosomes have been instrumental in the early discovery of cancer, and have been found to be effective in stage therapy, recurrence monitoring, and drug selection. Biosensors based on these target related biomarkers convert the tested substances into quantifiable signals such as electrical and optical signals through signal transduction, which has the advantages of high sensitivity, simple operation, and low invasiveness.

Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent mA regulation.

Disuse bone loss is prone to occur in individuals who lack mechanical stimulation due to prolonged spaceflight or extended bed rest, rendering them susceptible to fractures and placing an enormous burden on social care; nevertheless, the underlying molecular mechanisms of bone loss caused by mechanical unloading have not been fully elucidated. Numerous studies have focused on the epigenetic regulation of disuse bone loss; yet limited research has been conducted on the impact of RNA modification bone formation in response to mechanical unloading conditions. In this study, we discovered that mA reader IGF2BP1 was downregulated in both osteoblasts treated with 2D clinostat and bone tissue in HLU mice.

A resilience assessment framework for slopes considering multiple performance indicators.

The performance assessment of slopes during various disturbances is important to ensure the safe service of slopes. Due to the four characteristics of slope engineering, it is difficult for existing resilience evaluation models to accurately reflect slope performance. To address this problem, a resilience evaluation model applicable to slopes was developed in this study.

Analysis of geological characteristics and potential factors of formation damage in coalbed methane reservoir in Northern Qinshui basin.

Given the suboptimal physical properties and distinctive geological conditions of deep coalbed methane reservoirs, any reservoir damage that occurs becomes irreversible. Consequently, the protection of these deep coalbed methane reservoirs is of paramount importance. This study employs experimental techniques such as scanning electron microscopy, X-ray diffraction, and micro-CT imaging to conduct a comprehensive analysis of the pore structure, mineral composition, fluid characteristics, and wettability of coal seams 3# and 15# in the northern Qinshui Basin of China.

A noninvasive hyperkalemia monitoring system for dialysis patients based on a 1D-CNN model and single-lead ECG from wearable devices.

This study aimed to develop a real-time, noninvasive hyperkalemia monitoring system for dialysis patients with chronic kidney disease. Hyperkalemia, common in dialysis patients, can lead to life-threatening arrhythmias or sudden death if untreated. Therefore, real-time monitoring of hyperkalemia in this population is crucial.

In(III)-Catalyzed 1,2-Hydrophosphorylation of 3-Alkynyl-3-hydroxyisoindolinones to 3,3-Disubstituted Isoindolinones Featuring Both Phosphoryl and Alkynyl Groups at the C3-Position.

We report a highly regioselective 1,2-addition of P(O)-H compounds to the in situ generated β,γ-alkynyl-α-ketimine derived from 3-alkynyl-3-hydroxyisoindolinones, which provided a general protocol for the preparation of 3,3-disubstituted isoindolinones featuring both phosphoryl and alkynyl groups at a quaternary carbon center. The use of only 2-5 mol % of an inexpensive catalyst (In(ClO)·8HO or Bi(OTf)) allowed the smooth output of the desired products under mild conditions (25 °C, 0.5-24 h) with a broad substrate scope (35 examples) in up to >99% yield.

Remodeling the Proinflammatory Microenvironment in Osteoarthritis through Interleukin-1 Beta Tailored Exosome Cargo for Inflammatory Regulation and Cartilage Regeneration.

Osteoarthritis (OA) presents a significant therapeutic challenge, with few options for preserving joint cartilage and repairing associated tissue damage. Inflammation is a pivotal factor in OA-induced cartilage deterioration and synovial inflammation. Recently, exosomes derived from human umbilical cord mesenchymal stem cells (HucMSCs) have gained recognition as a promising noncellular therapeutic modality, but their use is hindered by the challenge of harvesting a sufficient number of exosomes with effective therapeutic efficacy.

Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy.

Phytochemicals are typically natural bioactive compounds or metabolites produced by plants. Phytochemical-loaded nanocarrier systems, designed to overcome bioavailability limitations and enhance therapeutic effects, have garnered significant attention in recent years. The coronavirus disease 2019 (COVID-19) pandemic has intensified interest in the therapeutic application of phytochemicals to combat viral infections.

Preclinical Evaluation of Ga/Lu-Labeled FAP-Targeted Peptide for Tumor Radiopharmaceutical Imaging and Therapy.

Fibroblast activation protein (FAP) has been considered a promising target for tumor imaging and therapy. This study designed a novel peptide, FAP-HXN, specifically targeting FAP and exhibiting significant potential as a radionuclide-labeled theranostic agent. Preclinical studies were conducted to evaluate the potency, selectivity, and efficacy of FAP-HXN.

[Research progress of bioactive scaffolds in repair and regeneration of osteoporotic bone defects].

Objective: To summarize the research progress of bioactive scaffolds in the repair and regeneration of osteoporotic bone defects.

Methods: Recent literature on bioactive scaffolds for the repair of osteoporotic bone defects was reviewed to summarize various types of bioactive scaffolds and their associated repair methods.

Results: The application of bioactive scaffolds provides a new idea for the repair and regeneration of osteoporotic bone defects.

Disrupting the dangerous alliance: Dual anti-inflammatory and anticoagulant strategy targets platelet-neutrophil crosstalk in sepsis.

Sepsis is a life-threatening disease characterized by excessive systemic inflammation and coagulopathy. Platelets and neutrophils form a "dangerous alliance" through crosstalk, promoting the inflammatory cytokine storm and coagulation disorders during sepsis. Platelet-neutrophil crosstalk leads to the formation of platelet-neutrophil complexes (PNCs), which are the central "protagonists" of this "dangerous alliance.

Construction and Characterization of a Mutant Library for the P Constitutive Promoter in Lactic Acid Bacteria.

Promoters are crucial elements for controlling gene expression in cells, yet lactic acid bacteria (LAB) often lack a diverse set of available constitutive promoters with quantitative characterization. To enrich the LAB promoter library, this study focused on the known strong constitutive promoter P in LAB. Through error-prone PCR and dNTP analog-induced random mutagenesis, a library of 247 mutants of P was generated by using the red fluorescent protein (RFP) fluorescence intensity as a high-throughput screening indicator in Streptococcus thermophilus.

Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system.

Background: A recent study conducted by the laboratory of the first author revealed that major depression is composed of two distinct subtypes: major dysmood disorder (MDMD) and simple dysmood disorder (SDMD). The latter is a less severe phenotype with fewer aberrant biological pathways. MDMD, but not SDMD, patients were identified to have highly sensitized cytokine/growth factor networks using stimulated whole blood cultures.

Promoting synergy among environmental and economic performances in food waste treatment by optimizing biogas residue management practices.

Improper management of biogas residue (BR) can reduce sustainability in the food waste treatment industry. To address this issue, a comprehensive evaluation framework, based on emergy analysis, carbon emissions and economic analysis, is proposed in this study, to explore how different BR disposal practices affect the comprehensive performance of the industry. A food waste treatment plant in Henan Province, China (anaerobic digestion (AD) + BR landfilling: Scenario 1 [S1]), and two alternative scenarios (S2: AD + BR incineration; S3: AD + BR composting) are investigated as a case study.

No Difference in Outcomes with Early vs. Late Antibiotic Prophylaxis for Term PROM: A Multi-Center Analysis.

Background: While guidelines suggest administering antibiotics 12 to 18 hours after the rupture of membranes in term premature rupture of membranes (PROM) women, in practice, clinicians tend to initiate prophylactic antibiotics as soon as possible to avoid risk of infection.

Objective: This study aimed to assess whether early administration of prophylactic antibiotics for term premature rupture of membranes reduces the incidence of maternal and neonatal infections.

Study Design: This multi-center, prospective cohort study included women with term premature rupture of membranes.

Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis.

The necrosis of pancreatic acinar cells is a key molecular event in the progression of acute pancreatitis (AP), with disturbances in mitochondrial energy metabolism considered to be a direct causative factor of acinar cell necrosis. Histidine triad nucleotide-binding protein 2 (HINT2) has been implicated in the development of various diseases, whereas its involvement in the progression of AP remains unclear. This study aims to investigate the role of HINT2 in AP.

Genome-wide identification of 1R-MYB transcription factors family and functional characterization of TrMYB130 under drought stresses in Trifolium repens (L.).

White clover (Trifolium repens L.) is a high-quality leguminous forage, but its short rooting habit, poor transpiration tolerance, and drought tolerance, have become a key factor restricting its growth and cultivation. 1R-MYB transcription factors (TFs) are a significant subfamily of TFs in plants, playing a vital role in regulating plant responses to drought stress, however, knowledge about the role of 1R-MYB transcription factors in white clover is still limited.

Downregulation of N6-Methyladenosine (m6A) Methylation of Sema4D mRNA Contributes to Treg Dysfunction and Allograft Rejection.

Regulatory T cells (Tregs) has been shown to be involved in the induction of transplantation tolerance in numerous models. Our previous work demonstrated that METTL14 loss impaired Treg function and hindered the establishment of transplantation tolerance. However, the underlying mechanisms remain unclear.

68Ga-FAPI PET/CT Depicted Non-FDG-Avid Malignant Peritoneal Mesothelioma.

Malignant peritoneal mesothelioma (MPM) is a rare and aggressive malignancy of mesothelial cells in the peritoneum. Herein, we describe the 68Ga-FAPI and 18F-FDG PET/CT findings of MPM in a 41-year-old man. In the present case, the primary and metastatic tumors showed intense 68Ga-FAPI accumulation but no significantly increased 18F-FDG uptake.

Collaborative performance of enzymatic saccharification and organic pollutant degradation from PHP (phosphoric acid coupled with hydrogen peroxide) pretreatment of lignocellulose.

As a newly developed technology, lignocellulose pretreatment of PHP (phosphoric acid coupled with hydrogen peroxide) can facilitate the enzymatic hydrolysis of pretreated lignocellulose for glucose production. It also has been found that the derived oxidative tail gas from pretreatment can facilely degrade organic pollutant. To balance the pollutant degradation and the glucose yield, the collaborative optimization on pretreatment was investigated.