Development of specific molecular markers for medicinal peony () with double flower.

In China, medicinal with double flowers (DFs) does not produce seeds, yet it possesses significantly higher paeoniflorin content compared with its single-flowered counterpart. The propagation of medicinal with DFs relies solely on rhizomes. However, due to economic motivations, the rhizomes of medicinal with single flowers (SFs) are often mixed with those of medicinal with DFs.

Selenium-assisted copper-catalyzed synthesis of phosphoramide from secondary phosphine oxide involving the construction of N-P bonds.

In this study, phosphoramide compounds were successfully synthesized a series of reaction transformations from P(O)H compounds. The process began with the formation of P-Se-Ar bonds, facilitated by the synergistic effect of phenylboronic acid, selenium, and appropriate ligands in the presence of copper. Following this, nucleophilic substitution reactions with amine compounds were conducted to create P-N bonds.

Tunable band gaps and conduction band edges of CdS/ZnS heterostructures - a first-principles-based prediction.

CdS/ZnS heterostructures with tunable band gaps are promising photocatalysts for solar- or visible-light-driven H production through water splitting. To predict how the bandgap changes with the heterostructure composition, density functional theory calculations with meta-GGA correction are performed. It is found that the band gaps of CdS and ZnS are reduced by up to 14.

Low back pain in China: Disease burden and bibliometric analysis.

Background: Low back pain has become a global problem. Since many traditional Chinese therapies are helpful for low back pain, the current status of low back pain in China may provide some insights to this issue.

Aim: To demonstrate the disease burden of low back pain in China and the response of Chinese scholars to this issue.

Diagnostic value of multi-tumor-associated autoantibody expression in esophageal squamous cell carcinoma and correlation of clinical features.

Objective: This study aimed to investigate the diagnostic value of 7-tumor associated autoantibodies (7-TAAB) and to evaluate the relationship between 7-TAAB and clinical features in esophageal squamous cell carcinoma (ESCC), which can be used to guide clinical diagnosis and treatment and achieve its clinical value.

Methods: (1) Blood specimens were collected from patients with ESCC who had not previously received antitumor therapy (ESCC group) and those who had normal medical check-ups in the hospital during the same period (control group). The concentrations of 7-TAAB (P53, PGP9.

Effect of immune checkpoint inhibitor time-of-day infusion on survival in advanced biliary tract cancer: a propensity score-matched analysis.

Background: Circadian rhythms in the immune system and anti-tumor responses are underexplored in cancer immunotherapy. Despite the success of immune checkpoint inhibitors (ICIs) in treating advanced biliary tract cancers (BTCs), not all patients benefit. This study examined whether the timing of ICI administration affects outcomes in advanced BTC patients.

Prognostic significance of hemoglobin, albumin, lymphocyte and platelet score in solid tumors: a pooled study.

Objective: The high hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been reported to be a good prognostic indicator for several malignancies. However, more evidence is needed before it can be introduced into clinical practice. Here, we systematically evaluated the predictive value of HALP for survival outcomes in patients with solid tumors.

Evaluation method of Driver's olfactory preferences: a machine learning model based on multimodal physiological signals.

Introduction: Assessing the olfactory preferences of drivers can help improve the odor environment and enhance comfort during driving. However, the current evaluation methods have limited availability, including subjective evaluation, electroencephalogram, and behavioral action methods. Therefore, this study explores the potential of autonomic response signals for assessing the olfactory preferences.

Machine Learning-based Prognostic Model for Brain Metastasis Patients: Insights from Blood Test Analysis.

Brain metastases, affecting 30% of solid tumor patients, have a substantial impact on clinical outcomes. Developing a clinically feasible and precise prognostic model is crucial for personalized and comprehensive treatment. Parameters from blood test were collected from brain metastases patients, and were used to construct the four models, including univariate Cox regression, stepwise regression, LASSO regression, and random survival forest (RSF).

Relationship between exosomes and cancer: formation, diagnosis, and treatment.

Exosomes are a member of extracellular vesicles. However, their biological characteristics differ from those of other vesicles, and recently, their powerful functions as information molecules, biomarkers, and carriers have been demonstrated. Malignancies are the leading cause of high morbidity and mortality worldwide.

Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway.

Cancer radical surgery is the primary treatment for melanoma, but almost all malignant melanoma patients get recurrence and metastasis after surgery and are eventually dead. This clinical dilemma appeals to better drugs for post-surgery therapy. Artemisinin is a safe and effective antimalarial drug used in the clinic for decades.

Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness.

The EGFR-TKIs (epidermal growth factor receptor-tyrosine kinases inhibitors) offer significant benefits to lung cancer patients with sensitive EGFR mutations; however, the development of acquired resistance poses a significant challenge and leads to poor prognosis. Thus, exploring novel therapeutic strategies to overcome EGFR-TKI resistance is urgently needed. This study introduces an innovative approach utilizing folic acid-modified milk exosomes loaded with c-kit siRNA (FA-mExo-siRNA-c-kit) to target EGFR-TKI resistance in lung cancer.

Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.

Heat acclimation (HA) is an evolutionarily conserved trait that enhances tolerance to novel stressors by inducing heat shock proteins (HSPs). However, the molecular mechanisms underlying this phenomenon remain elusive. In this study, we established a HA mouse model through intermittent heat stimulation.

HPV genotypes in invasive cervical cancer: prevalence, risk attribution, and optimized vaccine strategies in western China.

Background: Understanding the HPV genotype distribution in invasive cervical cancer (ICC) is essential for vaccine optimization. This study presents a comprehensive analysis of HPV genotypes in ICC tissues from patients in western China, with the aim of informing regional vaccine policy and prevention strategies.

Methods: DNA was extracted from 1,908 paraffin-embedded ICC samples, and 23 HPV genotypes were detected via PCR and reverse dot hybridization gene chip assays.

Health-related quality of life profiles in patients with rheumatoid arthritis: a latent profile analysis.

Background: Rheumatoid arthritis (RA) is a common rheumatic disease that most commonly affects joints and negatively impacts individuals' health-related quality of life (HRQoL). Although some studies have explored HRQoL of RA patients, existing studies treated RA patients as a homogeneous group based on their overall HRQoL and ignore the heterogeneity of patients' HRQoL patterns. This study aimed to identify subgroups of RA patients based on their HRQoL and variables associated with group membership.

Association between urinary arsenic and hearing threshold shifts in adults in the United States, National Health and Nutrition Examination Survey, 2015-2016.

Background: Hearing loss (HL) is a common sensory disorder in humans. Studies on the relationship between arsenic, which is a highly toxic and widely distributed heavy metal with a health risk to humans, and hearing status in humans are contradictory and mostly focused on people living in arsenic-contaminated areas. This study investigated the association between urinary arsenic levels and hearing threshold shifts in the general population in the United States.

Genome-wide identification, evolution and expression analysis unveil the role of genes in nitrogen utilization and nitrogen allocation.

Unlabelled: The rapid growth of Bamboo made the uptake and allocation of nitrogen much important. Nitrate is the main form that plant utilized nitrogen by nitrate transporters (NRTs) as well as ammonium salt. In this study, we identified 155 genes which mapped to 32 chromosomes out of 35 chromosomes in .

Nutritional nursing competence of clinical nurses and its influencing factors: a cross-sectional study.

Objective: Assessing the nutritional nursing competence of clinical nurses will enable nursing managers to develop measures to effectively address the nutritional nursing needs of patients. Therefore, the purpose of this study was to investigate the status quo and influencing factors of nutritional nursing competence of nurses in China.

Method: A cross-sectional survey was conducted among more than 1300 clinical nurses from 10 provinces in eastern, central and western China by using self-designed socio-demographic questionnaire and nutrition nursing ability scale compiled by Zhu Xinyi.

tRNA-derived small RNAs in disease immunity.

Recently, members of a unique species of non-coding RNA, known as transfer RNA-derived small RNAs (tsRNAs) have been reported to serve multiple molecular functions, including in cells that mediate immunity. Because of their low molecular weights, tsRNAs were previously difficult to detect and were thus overlooked, until now. In this review, we delve into the biogenesis of tsRNAs and their diverse biological functions, ranging from transcriptional regulation to modulation of mRNA translation.

Integrating oxygen-boosted sonodynamic therapy and ferroptosis engineered exosomes for effective cancer treatment.

Ferroptosis and sonodynamic therapy (SDT) are both promising therapeutic modalities, but their clinical application remains challenging due to the hypoxic tumor microenvironment and limited supply of polyunsaturated fatty acids. Developing an agent with oxygen-enhanced SDT and increased ferroptosis sensitivity is crucial for advancing tumor therapy. In this study, catalase (Cat) and Acyl-CoA synthetase long-chain family member 4 (ACSL4) highly expressed 4T1 cells were constructed lentivirus transfection.

Inhibiting autophagy selectively prunes dysfunctional tumor vessels and optimizes the tumor immune microenvironment.

Dysfunctional tumor vasculature, hypoxia, and an immunosuppressive microenvironment are significant barriers to effective cancer therapy. Autophagy, which is critical for maintaining cellular homeostasis and apoptosis resistance, is primarily triggered by hypoxia and nutrient deprivation, conditions prevalent in dysfunctional tumor vessels due to poor circulation. However, the role of autophagy in dysfunctional tumor endothelial cells and its impact on treatment and the tumor microenvironment (TME) remain poorly understood.

Reduced kidney size and renal function of high-grade vesicoureteral reflux and intrarenal reflux in contrast-enhanced voiding urosonography.

Background: Vesicoureteral reflux (VUR) is a common pediatric urological condition associated with renal scarring, hypertension, and chronic kidney disease. Contrast-enhanced voiding urosonography (ceVUS) has emerged as a promising technique for diagnosing and evaluating VUR, with intrarenal reflux (IRR) often detected using this method. This study aimed to explore the relationship between different VUR grades and IRR on ceVUS, and assess the impact of VUR and IRR on kidney size and function.

Insight into the history and trends of liver transplantation for echinococcosis: A bibliometric analysis.

Background: Liver transplantation (LT) has demonstrated favorable efficacy in managing end-stage alveolar echinococcosis. Nevertheless, the current research focal points and advancement trends remain ambiguous.

Aim: To map the research landscape to underscore critical areas of focus, influential studies, and future directions of LT for echinococcosis treatment.

Durable and deep response to CVD chemotherapy in SDHB-mutated metastatic paraganglioma: case report.

Introduction: Succinate dehydrogenase subunit B (SDHB)-mutated paragangliomas (PGLs) are rare neuroendocrine tumors characterized by increased malignancy, readily metastasizing, and poorer prognosis. Here we report a case of SDHB-mutated metastatic PGL, wherein the patient showed significant tumor shrinkage and complete symptom remission following chemotherapy. We aim to contribute additional evidence to the existing knowledge associated with SDHB-mutated PGLs.