139,558 results match your criteria: "Sichuan University; No[Affiliation]"

Background: Older adults with cognitive impairments will benefit from multicomponent interventions include cognitive training, exercise, and lifestyle modifications. Many digital therapeutic products predominantly focus on computerized cognitive training, lacking effective approaches to other crucial interventions. This study aimed to investigate the long term effects of multidimensional comprehensive cognitive intervention training program - Brain and Body Rehab Training (BBRT), which integrates multidomain cognitive training with physical-cognitive training and multidimensional lifestyle interventions on cognitive performance in participants with cognitive impairment after a 8-month follow-up.

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Background: Sodium vanadium fluorophosphate is a sodium ion superconductor material with high sodium ion mobility and excellent cyclic stability, making it a promising cathode material for sodium-ion batteries. However, most of the literature and patents report preparation through traditional methods, which involve complex processes, large particle sizes, and low electronic conductivity, thereby limiting development progress.

Objective: Aiming at the limitation of high cost and poor performance of vanadium sodium fluorophosphate cathode material, the low temperature and high-efficiency nano preparation technology was developed.

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Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice.

Int J Biol Sci

January 2025

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Cognitive impairment caused by anesthesia and surgery is one of the most common complications with multiple etiologies that occurs in elderly patients. The underlying mechanisms are not fully understood, and there is a lack of therapeutic strategies. Increasing evidence has demonstrated that myelin loss, abnormal phosphorylation of the tau protein and neuronal apoptosis are substantial driving factors of cognitive deficits.

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Background: There are differences in the extent of excision of articular processes, spinal processes and posterior ligamentum complexes (PLC) for posterior approach lumbar interbody fusion. Given that the biomechanical significance of these structures has been verified and that deterioration of the biomechanical environment is the main trigger for complications in both fused and adjacent motion segments, changes in decompression ranges may affect the potential risk of adjacent segmental disease (ASD) biomechanically; however, this topic has yet to be identified.

Methods: Posterior lumbar interbody fusion (PLIF) with different decompression strategies was simulated in a well-validated lumbosacral model.

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Background: Intervertebral disc degeneration disease (IVDD) is a prevalent orthopedic condition that causes chronic lower back pain, imposing a substantial economic burden on patients and society. Despite its high incidence, the pathophysiological mechanisms of IVDD remain incompletely understood.

Objective: This study aimed to identify metabolomic alterations in IVDD patients and explore the key metabolic pathways and metabolites involved in its pathogenesis.

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Alluaudite-type NaFe(SO) (NFS) with high theoretical energy density is regarded as the promising cathode of sodium-ion batteries (SIBs), while practical rate and cyclic performances are still hindered by intrinsic poor conductivity. Here, a facile method is developed, collaborating high-boiling organic solvents assisted colloidal synthesis (HOS-CS) with sintering for tailoring NaFe(SO) nanocrystals decorated by conductive carbon network toward high-rate-capability cathode of SIBs. Impressively, the as-prepared NaFe(SO)@MC provides 60.

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Objective: Primary intraventricular hemorrhage (PIVH) is a rare type of neurologic disorder and remains a challenge for cerebrovascular surgeons. This study intended to investigate the factors associated with neurosurgical intervention and its impact on outcome after PIVH.

Methods: We retrospectively included consecutive patients with PIVH admitted to at a single tertiary academic medical center in China.

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In Situ Proefferocytosis Microspheres as Macrophage Polarity Converters Accelerate Osteoarthritis Treatment.

Small

January 2025

Department of Orthopedics, Laboratory of Biological Tissue Engineering and Digital Medicine, Affiliated Hospital of North Sichuan Medical College, No. 1 The South of Maoyuan Road, Nanchong, Sichuan, 637000, P. R. China.

Efferocytosis in macrophages typically engages an anti-inflammatory positive feedback regulatory mechanism. In osteoarthritis (OA), characterized by imbalanced inflammatory homeostasis, the proinflammatory state of macrophages in the immune microenvironment can be reversed through enhanced efferocytosis. This study develops an in situ proefferocytosis hydrogel microsphere (macrophage polarity converter, H-C@IL) for OA treatment.

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Anthropogenic climate change is projected to become a major driver of biodiversity loss, destabilizing the ecosystems on which human society depends. As the planet rapidly warms, the disruption of ecological interactions among populations, species and their environment, will likely drive positive feedback loops, accelerating the pace and magnitude of biodiversity losses. We propose that, even without invoking such amplifying feedback, biodiversity loss should increase nonlinearly with warming because of the non-uniform distribution of biodiversity.

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[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].

Sheng Li Xue Bao

December 2024

Virtual Simulation and Artificial Intelligence Committee, Chinese Association for Physiological Sciences.

As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.

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Biopolymer-Based Flame Retardants and Flame-Retardant Materials.

Adv Mater

January 2025

Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu, 610064, China.

Polymeric materials featuring excellent flame retardancy are essential for applications requiring high levels of fire safety, while those based on biopolymers are highly favored due to their eco-friendly nature, sustainable characteristics, and abundant availability. This review first outlines the pyrolysis behaviors of biopolymers, with particular emphasis on naturally occurring ones derived from non-food sources such as cellulose, chitin/chitosan, alginate, and lignin. Then, the strategies for chemical modifications of biopolymers for flame-retardant purposes through covalent, ionic, and coordination bonds are presented and compared.

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Revolutionizing Dual-Band Modulation and Superior Cycling Stability in GDQDs-Doped WO Electrochromic Films for Advanced Smart Window Applications.

Small

January 2025

State Key Laboratory of Electronic Thin Films and Integrated Devices, National Engineering Research Center of Electromagnetic Radiation Control Materials, School of Integrated Circuit Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 610054, P. R. China.

Dual-band tungsten oxide (WO) electrochromic films are extensively investigated, yet challenges persist regarding complex fabrication processes and limited cyclic stability. In this paper, a novel approach to prepare graphdiyne quantum dots (GDQDs) doped WO films with a hexagonal crystal structure, is presented. Structural characterization reveals that the GDQDs/WO possesses a coral-like, loose structure with high crystallinity due to the synergistic modulation of morphology and crystallinity.

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Fractional CO Laser to Treat Surgical Scars: A System Review and Meta-Analysis on Optimal Timing.

J Cosmet Dermatol

January 2025

Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Background: Surgical scars with textural changes can be disfiguring and uncomfortable for patients. Various laser therapies have shown promise in softening and flattening these scars. Therefore, the authors conducted a systematic review and meta-analysis on the efficacy of fractional CO laser in treating surgical scars.

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Vertical organic electrochemical transistors (vOECTs) have received widespread attention in bioelectronics, wearable, and neuromorphic electronics due to their high transconductance (), low driving voltage, and biocompatibility. As key parameters of vOECTs, and switching speed (or transient time, τ) are vital for achieving satisfying performance in various practical applications. Here we employ vOECTs with varying top electrode widths for effective and switching speed modulation.

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Searching for single-molecule magnets (SMM) with large effective blocking barriers, long relaxation times, and high magnetic blocking temperatures is vitally important not only for the fundamental research of magnetism at the molecular level but also for the realization of new-generation magnetic memory unit. Actinides (An) atoms possess extremely strong spin-orbit coupling (SOC) due to their 5 orbitals, and their ground multiplets are largely split into several sublevels because of the strong interplay between the SOC of An atoms and the crystal field (CF) formed by ligand atoms. Compared to TM-based SMMs, more dispersed energy level widths of An-based SMMs will give a larger total zero field splitting (ZFS) and thus provide a necessary condition to derive a higher .

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Efficacy and safety of telitacicept in IgA nephropathy: a real-world study.

Ren Fail

December 2025

Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, China.

Background: IgA nephropathy (IgAN) is the most common primary glomerular disease in the world, and specific therapeutic methods for IgAN are limited. Telitacicept is a humanized fusion protein composed of a transmembrane activator and calcium-modulating cyclophilin ligand interactor receptor and human IgG.

Aim: To evaluate the efficacy and safety of telitacicept in adult patients with IgAN in a real-world study.

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Background: Stroke is an important contributor to disability and death globally. Hypertension is a main risk factor for recurrent stroke in patients with ischemic and hemorrhagic stroke or transient ischemic attack. Higher systolic blood pressure, diastolic blood pressure, pulse pressure and mean arterial pressure at admission are independently associated with the risk of stroke recurrence.

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Cerasus is a subgenus of Prunus in the family Rosaceae that is popular owing to its ornamental, edible, and medicinal properties. Understanding the evolution of the Cerasus subgenus and identifying selective trait loci in edible cherries are crucial for the improvement of cherry cultivars to meet producer and consumer demands. In this study, we performed a de novo assembly of a chromosome-scale genome for the sweet cherry (Prunus avium L.

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Background: Near-infrared spectroscopy (NIRS) enables a non-invasive measurement of tissue oxygen saturation (StO) in regions illuminated by near-infrared lights. Vascular occlusion test (VOT) serves as a model to artificially induce forearm ischemia-reperfusion. The combination of StO monitoring and VOT allows for dynamic evaluation of the balance between oxygen delivery and consumption in tissue, as well as the functional reserve of microcirculation.

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Application of low-intensity anticoagulation after On-X mechanical aortic valve replacement.

J Cardiothorac Surg

January 2025

Cardiac Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology, Chengdu, Sichuan Province, 610072, China.

Objective: To explore the safety and efficacy of low-intensity anticoagulation in patients after On-X mechanical aortic valve replacement.

Methods: A total of 104 patients undergoing aortic valve replacement in Cardiac Surgery Department of Sichuan Provincial People's Hospital from December 2018 to December 2021 were randomly divided into low-intensity anticoagulant (INR:1.5-2.

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Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis.

BMC Cancer

January 2025

Department of Urology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, China.

Objective: Sarcopenia, a condition characterized by the gradual decline of muscle mass, strength, and function, is a key indicator of malnutrition in cancer patients and has been linked to poor prognoses in oncology. Sarcopenia is commonly assessed by measuring the skeletal muscle index (SMI) of the third lumbar spine (L3) using computed tomography (CT). This meta-analysis aimed to explore the relationship between low SMI and clinicopathological features, as well as prognosis, in individuals with endometrial cancer (EC).

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Background: The St-genome-sharing taxa are highly complex group of the species with the St nuclear genome and monophyletic origin in maternal lineages within the Triticeae, which contains more than half of polyploid species that distributed in a wide range of ecological habitats. While high level of genetic heterogeneity in plastome DNA due to a reticulate evolutionary event has been considered to link with the richness of the St-genome-sharing taxa, the relationship between the dynamics of diversification and molecular evolution is lack of understanding.

Results: Here, integrating 106 previously and 12 newly sequenced plastomes representing almost all previously recognized genomic types and genus of the Triticeae, this study applies phylogenetic reconstruction methods in combination with lineage diversification analyses, estimate of sequence evolution, and gene expression to investigate the dynamics of diversification in the tribe.

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Machine learning (ML) has garnered significant attention for its potential to enhance the accuracy of genomic predictions (GPs) in various economic crops with the use of complete genomic information. Genome-wide association studies (GWAS) are widely used to pinpoint trait-related causal variant loci in genomes. However, the simultaneous integration of both methods for crop genome prediction necessitates further research.

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Plant pathogens pose a continuous threat to global food production. Recent discoveries in plant immunity research unveiled a unique protein family characterized by an unusual resistance protein structure that combines two kinase domains. This study demonstrates the widespread occurrence of tandem kinase proteins (TKPs) across the plant kingdom.

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