973 results match your criteria: "Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital.[Affiliation]"

Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation.

Cell Metab

December 2024

Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

The effect of the serine/glycine-free diet (-SG diet) on colorectal cancer (CRC) remains unclear; meanwhile, programmed death-1 (PD-1) inhibitors are less effective for most CRC patients. Here, we demonstrate that the -SG diet inhibits CRC growth and promotes the accumulation of cytotoxic T cells to enhance antitumor immunity. Additionally, we also identified the lactylation of programmed death-ligand 1 (PD-L1) in tumor cells as a mechanism of immune evasion during cytotoxic T cell-mediated antitumor responses, and blocking the PD-1/PD-L1 signaling pathway is able to rejuvenate the function of CD8+ T cells recruited by the -SG diet, indicating the potential of combining the -SG diet with immunotherapy.

View Article and Find Full Text PDF

Reports on the application of metagenomic next-generation sequencing (mNGS) in adult patients with severe pneumonia after cardiac surgery remain limited. This study aimed to evaluate the clinical outcomes of mNGS analysis of bronchoalveolar lavage fluid (BALF) in such patients.A retrospective cohort study was conducted on adult patients with severe pneumonia after cardiac surgery.

View Article and Find Full Text PDF

Objectives: To assess the correlation between the use of artificial intelligence (AI) software and burnout in the radiology departments of hospitals in China.

Methods: This study employed a cross-sectional research design. From February to July 2024, an online survey was conducted among radiologists and technicians at 68 public hospitals in China.

View Article and Find Full Text PDF
Article Synopsis
  • Cervical cancer is a prevalent type of cancer affecting women's reproductive systems, especially in developing nations, but skin metastasis from it is rare.
  • The study discusses a case of a 44-year-old woman with stage IIA gastric-type endocervical adenocarcinoma.
  • After treatment involving a radical hysterectomy and chemoradiation, the patient developed skin metastasis in the vulvar area two years later.
View Article and Find Full Text PDF

Ab-Amy 2.0: Predicting light chain amyloidogenic risk of therapeutic antibodies based on antibody language model.

Methods

January 2025

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; School of Healthcare Technology, Chengdu Neusoft University, Chengdu 611731, China. Electronic address:

Therapeutic antibodies have emerged as a promising treatment option for a wide range of diseases. However, the light chain of antibodies can potentially induce amyloidosis, a condition characterized by protein misfolding and aggregation, posing a significant safety concern. Therefore, it is crucial to assess the amyloidogenic risk of therapeutic antibodies during the early stages of drug development.

View Article and Find Full Text PDF

Edge advances in nanodrug therapies for osteoarthritis treatment.

Front Pharmacol

October 2024

Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Center of Organ Transplantation, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.

As global population and lifestyles change, osteoarthritis (OA) is becoming a major healthcare challenge world. OA, a chronic condition characterized by inflammatory and degeneration, often present with joint pain and can lead to irreversible disability. While there is currently no cure for OA, it is commonly managed using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and glucosamine.

View Article and Find Full Text PDF

Lack of retinal degeneration in a Dram2 knockout mouse model.

Vision Res

January 2025

The Sichuan Provincial Key Laboratory for Human Disease Gene Study and Center for Medical Genetics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China; Key Laboratory of Tibetan Medicine Research, Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Qinghai Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; Department of Ophthalmology, Shangqiu First People's Hospital, Shangqiu, Henan, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China. Electronic address:

Damage-regulated autophagy modulator 2 (DRAM2) is a homologue of the DRAM family protein, which can induce autophagy process. In the retina, DRAM2 is located to the inner segment of photoreceptors, the apical surface of retinal pigment epithelial (RPE) cells, and the lysosome. Pathogenic variants of DRAM2 lead to autosomal recessive Cone-rod dystrophy 21 (CORD21).

View Article and Find Full Text PDF

Unveiling the role of sTLR2: A novel biomarker for predicting septic-associated AKI.

Cytokine

December 2024

Geriatric Diseases Institute of Chengdu, Department of Geriatrics, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China; Geriatric Diseases Institute of Chengdu, Department of Intensive Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China; Center for Medicine Research and Translation, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China. Electronic address:

Article Synopsis
  • * Researchers studied 116 septic patients, separating them into AKI and non-AKI groups, and analyzed various biomarkers within 24 hours of ICU admission.
  • * Key findings indicated that higher levels of certain biomarkers, particularly sTLR2 and IL-6, along with higher APACHE II scores, were predictive of AKI, with sTLR2 being nearly as reliable as creatinine in predicting the condition.
View Article and Find Full Text PDF

Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL.

bioRxiv

October 2024

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China; The Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine, Center for Medical Genetics, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 promote the endocytosis and degradation of FZD receptors to inhibit Wnt signaling, and their function is antagonized by R-spondin (RSPO) proteins.

View Article and Find Full Text PDF
Article Synopsis
  • Non-small cell lung cancer (NSCLC) is a major cause of cancer deaths, and immune checkpoint inhibitors (ICIs) are key treatments, but not all patients benefit from them, highlighting the need for predictive biomarkers.
  • Researchers developed a deep learning model (ResNet18-PG) using histopathology images from NSCLC patients to create an ICI-related pathological prognostic signature (ir-PPS) aimed at identifying patient prognosis and treatment response.
  • The model showed strong predictive capability with an AUC of 0.918 and identified low-risk patients who had significantly better progression-free survival (PFS) compared to high-risk patients, demonstrating its potential in optimizing ICI treatment selection.
View Article and Find Full Text PDF
Article Synopsis
  • Critically ill patients often experience pain, which can lead to various physiological issues; remifentanil is commonly used for pain relief in ICUs but has significant side effects, prompting the exploration of oliceridine as a potentially safer alternative.
  • A multicenter trial in China will compare oliceridine and remifentanil in 292 mechanically ventilated patients, focusing on pain and sedation management using specific observational scales.
  • The primary outcome is the percentage of time patients remain within target pain relief during treatment, while secondary outcomes will assess factors like side effects, sedation needs, and overall ICU recovery metrics.
View Article and Find Full Text PDF

Purpose: We analyzed the pathogenic bacteria and antibiotic resistance distributions in patients with biliary tract infections (BTI) using samples from the Antimicrobial Resistant Investigation Network of Sichuan Province (ARINSP) to promote the rational use of antibiotics to reduce multidrug resistance.

Patients And Methods: Participating hospitals identified isolates between 2017 and 2023 and conducted antimicrobial susceptibility tests. Isolated bacteria were identified and tested for drug sensitivity using MOLDI-TOF mass spectrometry system, VITEK automated drug sensitivity system and paper diffusion method, and the results were interpreted with reference to CLSI M100 30th edition standards.

View Article and Find Full Text PDF

Deletion of Transmembrane protein 184b leads to retina degeneration in mice.

Cell Prolif

October 2024

The Sichuan Provincial Key Laboratory for Human Disease Gene Study and Center for Medical Genetics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Transmembrane protein 184b (Tmem184b) has been implicated in axon degeneration and neuromuscular junction dysfunction. Notably, Tmem184b exhibits high expression levels in the retina; however, its specific function within this tissue remains poorly understood. To elucidate the role of Tmem184b in the mammalian visual system, we developed a Tmem184b knockout (KO) model for further investigation.

View Article and Find Full Text PDF

Global burden of chronic kidney disease in adolescents and young adults, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Front Endocrinol (Lausanne)

October 2024

Department of Health Management Center & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Article Synopsis
  • The study focuses on chronic kidney disease (CKD) among adolescents and young adults (ages 15-39), revealing that its global impact is often underestimated.
  • Between 1990 and 2019, the incidence rate of early-onset CKD notably increased, while death rates decreased and disability-adjusted life years (DALY) remained stable, with middle SDI countries showing the highest incidence.
  • Major risk factors contributing to early-onset CKD included high systolic blood pressure, elevated fasting plasma glucose, and body mass index, highlighting the need for tailored healthcare strategies.
View Article and Find Full Text PDF

Association between programmed death protein 1-related single-nucleotide polymorphisms and immune-related adverse events induced by programmed death protein 1 inhibitors-a pilot study.

Int Immunopharmacol

December 2024

Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address:

Programmed death protein 1 (PD-1) inhibitors have potent anti-tumor activities. However, they often result in immune-related adverse events (irAEs) of varying severity. Therefore, the factors affecting the incidence of irAEs warrant urgent investigation.

View Article and Find Full Text PDF

Exploring retinal degenerative diseases through CRISPR-based screening.

Mol Biol Rep

September 2024

Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Article Synopsis
  • CRISPR/Cas9 is a cool tool that helps scientists change genes and has been used in important fields like cancer and virus research.
  • The article talks about using CRISPR to study eye diseases, which is really important but hasn't been explored much yet.
  • It aims to share details about CRISPR methods, give examples of successful studies, and suggest ways to use these techniques to learn more about eye health.
View Article and Find Full Text PDF

Smart Implantable Hydrogel for Large Segmental Bone Regeneration.

Adv Healthc Mater

December 2024

The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Large segmental bone defects often lead to nonunion and dysfunction, posing a significant challenge for clinicians. Inspired by the intrinsic bone defect repair logic of "vascularization and then osteogenesis", this study originally reports a smart implantable hydrogel (PDS-DC) with high mechanical properties, controllable scaffold degradation, and timing drug release that can proactively match different bone healing cycles to efficiently promote bone regeneration. The main scaffold of PDS-DC consists of polyacrylamide, polydopamine, and silk fibroin, which endows it with superior interfacial adhesion, structural toughness, and mechanical stiffness.

View Article and Find Full Text PDF

Capture of RNA-binding proteins across mouse tissues using HARD-AP.

Nat Commun

September 2024

Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, 610041, China.

RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism, but a comprehensive picture of RBP expression across tissues is lacking. Here, we describe our development of the method we call HARD-AP that robustly retrieves RBPs and tightly associated RNA regulatory complexes from cultured cells and fresh tissues. We successfully use HARD-AP to establish a comprehensive atlas of RBPs across mouse primary organs.

View Article and Find Full Text PDF

Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes.

J Transl Med

September 2024

Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 West Second Section, First Ring Road, Chengdu, 610072, China.

Background: The glucose transporter 2 (GLUT2) is constitutively expressed in pancreatic beta cells and hepatocytes of mice. It is the most important receptor in glucose-stimulated insulin release and hepatic glucose transport. The Sema4D is a signalin receptor on cell membranes.

View Article and Find Full Text PDF

Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development.

Asian J Androl

September 2024

The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Centre for Medical Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

This study was conducted retrospectively on a cohort of 68 patients with steroid 5 α-reductase 2 (SRD5A2) deficiency and 46,XY disorders of sex development (DSD). Whole-exon sequencing revealed 28 variants of SRD5A2, and further analysis identified seven novel mutants. The preponderance of variants was observed in exon 1 and exon 4, specifically within the nicotinamide adenine dinucleotide phosphate (NADPH)-binding region.

View Article and Find Full Text PDF

Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema.

Orphanet J Rare Dis

September 2024

Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 The First Ring Road West 2, Chengdu, Sichuan, 610072, China.

Article Synopsis
  • Hereditary angioedema (HAE) is a rare genetic condition that causes recurrent swelling and can be life-threatening, with limited ways to predict or prevent attacks.
  • A novel mutation in the SERPING1 gene was found in a Han family with HAE, leading to cellular dysfunction due to increased C1-INH levels and subsequent mitochondrial damage.
  • Monitoring intracellular calcium levels may provide a new method for predicting HAE attacks, which could improve management strategies for the condition.
View Article and Find Full Text PDF

Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy.

Elife

September 2024

The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Familial exudative vitreoretinopathy (FEVR) is a severe genetic disorder characterized by incomplete vascularization of the peripheral retina and associated symptoms that can lead to vision loss. However, the underlying genetic causes of approximately 50% of FEVR cases remain unknown. Here, we report two heterozygous variants in calcyphosine-like gene () that is associated with FEVR.

View Article and Find Full Text PDF

At the heart of inflammation: Unravelling cardiac resident macrophage biology.

J Cell Mol Med

September 2024

Center of Clinical Pharmacology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Cardiovascular disease remains one of the leading causes of death globally. Recent advancements in sequencing technologies have led to the identification of a unique population of macrophages within the heart, termed cardiac resident macrophages (CRMs), which exhibit self-renewal capabilities and play crucial roles in regulating cardiac homeostasis, inflammation, as well as injury and repair processes. This literature review aims to elucidate the origin and phenotypic characteristics of CRMs, comprehensively outline their contributions to cardiac homeostasis and further summarize their functional roles and molecular mechanisms implicated in the onset and progression of cardiovascular diseases.

View Article and Find Full Text PDF

Genome-Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia.

Adv Sci (Weinh)

October 2024

Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.

Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two-stage genome-wide association study (GWAS) and replication analysis in East Asian populations is conducted. The analysis identified LILRB2 in 19q13.

View Article and Find Full Text PDF