Mannose shows antitumour properties against lung cancer via inhibiting proliferation, promoting cisplatin‑mediated apoptosis and reducing metastasis.

It has been reported that mannose exerts antitumour effects against certain types of cancer. The present study was designed to evaluate whether mannose exerted potential anticancer effects on A549 and H1299 non‑small cell lung cancer (NSCLC) cells in vitro, which has not been reported previously. A Cell Counting Kit‑8 cell viability assay was used to assess the antiproliferative effects of mannose on NSCLC cells.

Mannose Suppresses the Proliferation and Metastasis of Lung Cancer by Targeting the ERK/GSK-3β/β-Catenin/SNAIL Axis.

Introduction: It has been found that mannose exerts antitumoural properties in vitro and in animal models. Whether mannose has potential anti-proliferative and anti-metastatic properties against non-small-cell lung cancer (NSCLC) is still unclear.

Methods: Here, we performed ex vivo experiments and established a nude mouse model to evaluate the anticancer effects of mannose on NSCLC cells and its effects on the ERK/GSK-3β/β-catenin/SNAIL axis.

Effect of EGFR gene polymorphism on efficacy of chemotherapy combined with targeted therapy for non-small cell lung cancer in Chinese patients.

EGFR-TKI had become the first-line treatment of metastatic NSCLC and widely used in clinical. It was reported that there was difference in response rate between NSCLC patients with or without EGFR mutation. However, there was no relevant studies about the difference in clinical response among patients with different kinds of EGFR mutation.

[Experimental study of simvastatin induced apoptosis of K562 cells by caspase-12 activation].

Objective: To explore the apoptotic effect of simvastatin on K562 cells through Caspase-12 activation.

Methods: Morphological changes of apoptotic cells were observed by Hoechst33258 fluorescent staining under fluorescent microscope; Apoptosis rate of cells was determined with annexin V-FITC/PI double staining by flow cytometry; Intracellular calcium concentration ([ca2+]i) was measured by Laser Scanning Confocal Microscope(LSCM); The expression levels of GRP78 and Calpain gene mRNA were determined by RT-PCR; The expression levels of Caspase-3,-6,-7,-9,-12 and GRP78 proteins were evaluated by Western blot.

Results: Typical morphological changes of K562 apoptosis cells were observed post 72 hours treated with 10, 20, 30 micromol/L simvastatin.