Combined Addiction and Neurobiological Targets: An In Silico Analysis of Areca Nut and Areca Nut with Tobacco Biomolecules.

Background: The addictive potential of areca nut (AN) and tobacco is well-documented, but their combined neurobiological effects in AN-containing tobacco products (ANTP) remain obscure. This study employed a three-stage in silico approach to investigate the potential targets and pathways associated with the addictive properties of AN alone and in ANTP.

Materials And Methods: Bioactive molecules were retrieved for AN and tobacco, followed by target prediction and pathway enrichment analysis.

Estimation of health literacy levels in patients with cardiovascular diseases in a Gulf country.

Introduction: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. In the United Arab Emirates (UAE), the prevalence of deaths associated with CVD is higher than the global average, and the incidence of premature coronary heart disease is 10-15 years earlier than in Western nations. In patients with CVD, inadequate health literacy (HL) is significantly associated with poor health outcomes.

Health literacy levels in patients with type 2 diabetes in an affluent Gulf country: a cross-sectional study.

Objectives: To identify health literacy levels in patients with type 2 diabetes mellitus in the United Arab Emirates (UAE).

Intervention: Nationwide cross-sectional survey.

Setting And Participants: Individuals with type 2 diabetes mellitus attending outpatient diabetes clinics in all emirates of the UAE were surveyed between January 2019 and May 2020.

Statewide Survey of Psychological Distress Among People of Tamil Nadu in the COVID-19 Pandemic.

Background: COVID-19-driven pandemic has caused panic, fear, and stress among all strata of society. The study aimed to assess stress and the factors that influence it in a representative population in the state of Tamil Nadu (TN)-a state in the southern India where the levels of stress have not been measured yet.

Methods: From April 13 to April 25, 2020, we conducted an online survey among the TN population using the snowball sampling technique, collecting basic demographic data.

Isolated Sphenoid Sinusitis.

Isolated disease of sphenoid sinus is rare, representing 2-3% of all paranasal sinus lesions. Usually it is inflammatory in origin; very rarely it is due to neoplasm. Isolated sphenoid sinus diseases are difficult to diagnose and to treat because either the symptoms are very vague or they present to us very late as a result of disease complications.

Non-auditory Effects of Noise Pollution on Health: A Perspective.

Noise is an ever increasing product of our environment. The increased noise levels cause auditory as well as non-auditory effects on health. The relationship between noise and hearing loss has been well established.

Salivary Flow Alteration in Patients Undergoing Treatment for Schizophrenia: Disease-Drug-Target Gene/Protein Association Study for Side-effects.

Background: Salivary flow alteration (SA), is a known unwarranted effect of schizophrenic medications. It manifest either as reduced (xerostomia) or increased (sialorrhea) SA, among treated schizophrenic patients. It is believed that the SA is due to action of the drugs/disease process involving the muscarinic receptor-3 to process acetyl choline, the common neurotransmitter.

Risk of cognition alteration and emotional frailty via circulating transcriptome in treatment naïve head and neck squamous cell cancer patients.

Background: There is a dearth of research examining the association between differential expression (DE) of genetic transcritome associated with cognition alteration (CA) and emotional frailty (EF) in treatment naïve head and neck squamous cell carcinoma (HNSCC) patients. The present study was undertaken to identify the DE of mRNA of CA-EF in HNSCC tumor and correlate with clinical and other known genetic factors that promote oncogenesis as well as CA-EF.

Material And Methods: Using Genome-Wide Association Studies, putative genes associated with CA-EF(Prixie Fixie score ≥0.

Oculosporidial polyp infected secondarily by Enterobius vermicularis.

Oculosporidiosis caused by Rhinosporidium seeberi is a common infectious disease of south India. Here we are reporting a rare case of oculosporidial polyp containing another parasite Enterobius vermicularis as a co infection. This is the first report of its kind in literature.

Myofibroblastoma of female breast masquerading as schirrous malignancy - a rare case report with review of literature.

Myofibroblastoma is a rare benign mesenchymal tumour of the breast commonly reported in males. It is a spindle cell neoplasm exhibiting myofibroblastic differentiation with characteristic immunohistochemical staining. Herein, we present a case of myofibroblastoma in a premenopausal female which was mimicking like malignancy clinically.

Enterobius vermicularis worm granuloma mimicking like a pseudo tumor in the anal canal: An unusual clinical presentation.

Enterobius vermicularis is one of the most common intestinal nematode worldwide. Enterobius rarely causes a symptomatic disease. We report here an unusual case of a 60-year old man who came with a polypoidal growth in the anal canal increasing in size for past 20 years.