Child-Pugh Score and Vitamin D: Exploring a New Frontier in Liver Cirrhosis Assessment.

This study investigates the relationship between vitamin D levels and liver cirrhosis severity, a leading cause of global morbidity and mortality. Chronic liver diseases, stemming from conditions such as hepatitis, alcohol use, non-alcoholic fatty liver disease, autoimmune diseases, and cryptogenic disorders, disrupt vitamin D metabolism, as the liver converts dietary and skin-derived vitamin D into 25-hydroxyvitamin D (25[OH]D), the primary circulating form. The cross-sectional study conducted at the Department of General Medicine of BLDE (DU) Shri.

A Rare Presentation of Synchronous Thyroglossal Cyst and Branchial Cyst in an Adult Male Patient.

The most common congenital cervical masses are thyroglossal cysts followed by branchial cleft anomalies. However, their synchronous presentation is uncommon. A man in his early thirties visited our ear, nose, and throat (ENT) outpatient department (OPD) with complaints of a three-month history of right-side neck swelling.

Hematological Changes in Platelet Apheresis Donors: An Observational Study.

Background The demand for platelet concentrates is increasing for treating patients in clinics such as oncology. Single donor platelets (SDPs) collected through apheresis offer a lower risk of transfusion-related complications. Aim This observational study aims to evaluate hematological changes in donors before and after platelet donation via apheresis, shedding light on donor safety and eligibility criteria.

Perception and Impact of the Family Adoption Program (FAP) Among Indian Medical Students: Benefits and Challenges.

Background The National Medical Commission of India recommends the Family Adoption Program (FAP) under Competency-Based Medical Education (CBME) in the MBBS curriculum. Medical students can witness firsthand the living situations of the people they treat as patients in the hospital through community participation. Students also learn how various health factors impact patients in real-world settings.

The Impact of Bhramari Pranayama and Om Chanting on Post-operative Wound Healing: A Focus on the Nitric Oxide Pathway.

Introduction  is a complex process influenced by various physiological and psychological factors. Stress, in particular, has been shown to impair wound healing by affecting the immune response and slowing the repair process. Yoga-based relaxation techniques, such as bhramari pranayama and Om chanting, have demonstrated the potential to reduce stress and improve overall well-being.

Managing Amitraz Poisoning: Epidemiological Data and Clinical Insights From a Tertiary Care Hospital in Southern India.

Background Amitraz is a formamidine insecticide and acaricide that acts on α2 adrenergic receptors. There is limited information in the literature regarding the toxicity of this compound and treatment of poisoning. Here, we have studied the epidemiology, symptoms, signs, complications, abnormalities in the tests, management, and prognosis of individuals who were admitted to a tertiary care hospital with acute amitraz intoxication.

Role of Yoga in Modulating Vascular Aging in Type 2 Diabetes Mellitus.

Background: Diabetes is one of the top 10 global causes of mortality, with considerable contributions to cardiovascular disease (CVD), respiratory illness, and cancer. Yoga is a traditional Indian mind-body practice that has been linked to improved cardiovascular health, diabetic management, and reduced stress.

Objective: The purpose of this study was to assess the effect of yoga on vascular aging in patients with type 2 diabetes mellitus (T2DM).

Castleman's Disease Presenting as an Unusual Pelvic Retroperitoneal Mass.

Castleman's disease (CD) is characterised by benign lymphoepithelial proliferation and is a peculiar form of angiofollicular lymph node hyperplasia rather than a neoplasm or a hamartoma. CD is broadly classified as unicentric CD (UCD) and multicentric CD. In the unicentric variant, patients have localised disease affecting only a single lymph node or a group of adjacent nodes in a single region, which clinically presents as an enlarging mass without any other significant symptoms.

Effect of bioactive compounds of on proteins of Wnt/β catenin pathway in pulmonary hypertension by in silico approach.

Modulation of the Wnt/β-catenin signaling pathway may aid in discovering new medications for the effective management of pulmonary artery hypertension (PAH). Given the therapeutic potential of Mucuna pruriens in several diseases, the present study aimed to analyze interactions of different bioactive compounds of Mucuna pruriens plant seeds with Wnt/β-catenin pathway targeting its various components like Wnt 3a, Frizzled 1, LRP 5/6, β-catenin, Disheveled, cyclin D1 by in silico analysis. The proposed work is based on computational analysis including ADME/T properties, by a Swiss ADME server.

Analysis of Single Nucleotide Polymorphisms of Liver X Receptor Alpha (LXR-α) Gene in Diabetic Kidney Disease.

Introduction Genetic factors significantly contribute to the progression of diabetic kidney disease (DKD), which is one of the world's most common causes of chronic kidney disease (CKD). Inflammation, glucose homeostasis, and lipid metabolism are all significantly influenced by the liver X receptor alpha (LXR-α) gene. Single nucleotide polymorphisms in the liver X receptor alpha gene may result in the altered function of the gene, making the individual susceptible to DKD.

Assessment of the Prevalence and Types of Mental Compulsions in Patients With Obsessive-Compulsive Disorder in North Karnataka: A Cross-Sectional Study.

Background: Obsessive-compulsive disorder (OCD) is a significant mental condition characterized by the presence of obsessions and compulsions. Mental compulsions are defined as compulsions with no overt behavioral or motoric symptoms, such as repeating certain words or phrases in the mind. The exact prevalence of mental compulsions could be underestimated due to measurement issues using the Y-BOCS (Yale-Brown Obsessive Compulsive Scale) and its clinical characteristics.

A Report of a Rare Case of Vagococcus fluvialis Isolated From Urine: Clinical Significance of Vagococcus Species With an Update of the Available Literature.

species (spp.) are gram-positive cocci that are rarely reported in humans. These bacteria share physiological, cultural, and biochemical properties with spp.

Arthroscopic Management of Posterior Ankle Impingement Syndrome - A Case Series.

Introduction: Posterior ankle impingement is a common cause of chronic ankle pain. Although nonoperative treatment is initially preferred, there are surgical options if the symptoms are persistent. Minimally invasive arthroscopic procedures reduce surgical trauma and enable an early return to routine activities.

Impact of Phacoemulsification on Trabeculectomy Bleb Function and Morphology in Primary Angle Closure Glaucoma: A Comparative Study of the Visco-Cushion Effect.

Purpose This study evaluates the impact of phacoemulsification on trabeculectomy bleb morphology and intraocular pressure (IOP) control in patients with primary angle closure glaucoma (PACG). The study also evaluates possible alterations in these effects by intra-operative blocking of internal sclerostomy by high-density viscoelastic (visco-cushion). Methods This is a single-center, interventional, prospective study including patients with PACG who underwent phacoemulsification post-trabeculectomy.

Serum interleukin-6 and high sensitivity C-reactive protein levels and their correlation with the vitiligo disease activity and extent: A cross-sectional study of 58 patients.

Vitiligo is an acquired depigmenting disorder due to the destructive loss of melanocytes, clinically presenting as hypopigmented or depigmented macules and/or patches. Many theories have been proposed to explain its etiopathogenesis among which cell-mediated immunity is one of the crucial links. Estimation of vitiligo activity and extent in a patient is important in tailoring an optimal treatment regimen.

Digital Ischemia and Gangrene: An Unusual Presentation of Chronic Myeloid Leukemia.

Digital ischemia with gangrene is a rare manifestation of chronic myeloid leukemia (CML). We report a rare CML case with severe thrombocytosis presenting clinically as digital ischemia and gangrene, the sole primary symptom. A 40-year-old patient presented with pain and discoloration of the tips of the ring and little fingers of the right hand for 20 days, which later progressed to dry gangrene with a line of demarcation and pre-gangrenous changes in the index and middle fingers.

The Effect of Iron Deficiency Anemia on Hemoglobin Glycation in Diabetics and Non-diabetics.

Background Iron deficiency anemia (IDA) is the most prevalent form of nutritional anemia worldwide, affecting a substantial portion of the population. It has significant negative effects on health and the economy, especially in poorer nations, and is more prevalent than anemia alone. Although hemoglobin A1c (HbA1c) is frequently used to track long-term glycemic management, several variables, including iron deficiency, might affect its values.

A Comparative Study of Sodium Alginate and Plasma Thrombin Cell Block in Diagnostic Cytopathology.

: Cell block is an indispensable supplement in the practice of cytopathology. The diagnostic utility of cytology specimens is significantly impacted by the capacity to generate sufficient cell blocks obtained from concentrated fluid samples or fine-needle aspiration specimens after routine processing. This routine processing involves getting directed passes to produce a cell block, especially if the cytopathologist believes additional immunocytochemical stains and/or molecular studies would be required.

Pre-emptive Nebulized Ketamine Versus Lidocaine for Post-tonsillectomy Pain Management in Children: A Comparative Study.

Background Tonsillectomy is associated with significant pain, and postoperative pain control is often unsatisfactory. There have been several methods adopted to treat postoperative pain, but none of the methods were effective, with patients continuing to undergo severe postoperative pain. Hence, our study aimed to compare the efficacy of pre-emptive nebulized ketamine versus pre-emptive nebulized lidocaine with a control group receiving nebulized saline for pain control in children undergoing tonsillectomy.

Awareness and Knowledge of Adverse Drug Reactions and Pharmacovigilance Among Medical and Nursing Students and Staff in a Tertiary Care Hospital.

Background Pharmacovigilance is defined as the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or other drug-related problems. Underreporting of adverse drug reactions (ADRs) is a global issue, and adequate knowledge among healthcare professionals is essential. Engaging young doctors and nursing professionals in pharmacovigilance is crucial for promoting ADR reporting.

Macrophage Migration Inhibitory Factor Gene Polymorphism in Acute Coronary Syndrome.

Background Acute coronary syndrome (ACS) is a result of the interplay between genetic and environmental risk factors. A unique cytokine macrophage migration inhibitory factor (MIF), expressed by inflammatory cells, acts via a cluster of differentiation 74 (CD74) and a cluster of differentiation 44 (CD44) receptors, leading to the recruitment of mononuclear neutrophils and lymphocytes. This cascade results in exaggerated inflammation and atherosclerosis.

CD64 Expression on Neutrophils (nCD64) as a Biomarker in Adult Patients With Sepsis: A Cross-Sectional Study.

Introduction Neutrophils that are at rest exhibit very low expression of CD64, the high-affinity immunoglobulin fragment crystallizable γ receptor I, which is also found in monocytes. Neutrophils that have been exposed to endotoxins or are infected express more CD64. Objectives The aim of this study was to assess the CD64 biomarker expression on neutrophils using the flow cytometry method and its comparison with total leukocyte count, C-reactive protein (CRP) level, and blood culture sensitivity test in the diagnosis of sepsis in adults.