An infected intracranial dermoid cyst at the region of torcular herophili: A case report.

Background: Dermoid cysts result from embryonic fusion anomalies, with intracranial dermoid cysts being rare (0.1-0.7% of intracranial tumors).

Indian Trial of Tranexamic acid in Spontaneous Intracerebral Hemorrhage study protocol.

Rationale: Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction in blood pressure. Tranexamic acid (TXA) a hemostatic drug that is widely available and safe can be a cost-effective treatment for ICH, if proven efficacious.

Hypothesis: Administration of TXA in ICH patients when given within 4.

Progressive Supranuclear Palsy in India: Past, Present, and Future.

Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the extensive range of Indian research on PSP up to the present and offers insights into both current initiatives and potential future directions for managing PSP within the region. Historical research contributions have spanned 80 publications from 1974 to 2023, encompassing diverse themes from clinical phenotyping and historical analysis to isolated investigative studies and therapeutic trials.

Graham-Little-Piccardi-Lassueur Syndrome with Mucosal Involvement: A Rare Case.

Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a type of lichen planopilaris. It mainly affects females aged 40-60 years. It is characterized by the triad of patchy cicatricial alopecia of the scalp, noncicatricial alopecia of the axilla and groin and a follicular spinous papule on the body, scalp, or both.

Assessment of the BODE Index and Its Association With Inflammatory Mediators in Chronic Obstructive Pulmonary Disease (COPD) Patients.

Background Chronic obstructive pulmonary disease (COPD) is a respiratory condition impacting daily activities of susceptible individuals and increasing the risk of respiratory infections and cardiovascular disease. Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity (BODE) index is applied clinically to measure the survival of COPD patients. Inflammatory mediators, including cytokines and chemokines, significantly contribute to the COPD pathology.

A novel diode laser intervention in the management of external invasive cervical resorption.

"Invasive cervical resorption (ICR)" is a rare category of "external root resorption." It is a progressive and destructive condition with an unclear cause. Managing external "ICR" presents a significant challenge, even to the most seasoned dental professionals.

Prospective Observational Cohort Study of Tenecteplase: Results From the Indian Registry in Ischemic Stroke-Tenecteplase.

Background: Tenecteplase has been approved for acute ischemic stroke at a dose of 0.2 mg/kg by the Indian licensing authority. A registry to evaluate the safety of tenecteplase was mandated by the licensing authority.

Short-Term Outcome of Patients in Delirium at Medical Intensive Care Unit.

Background: Delirium is highly prevalent in the Intensive Care Unit (ICU), and managing it in critically ill patients with severe comorbidities is challenging due to transient nature of symptoms. However its significance is underestimated, often overlooked and misdiagnosed by healthcare providers. In Nepal, limited studies has been done on delirium in medical ICUs hence this study aims to assess short-term outcome of admitted patients in delirium.

Endoscopic dilation of small-intestine strictures in Crohn's disease by balloon-assisted enteroscopy: a systematic review and meta-analysis.

Background: Balloon-assisted enteroscopy (BAE) (both single- and double-balloon enteroscopy) has garnered attention in the treatment of small intestine strictures in patients with Crohn's disease (CD). This study aimed to evaluate the pooled clinical outcomes of BAE-mediated endoscopic dilation of small intestine strictures in patients with CD.

Methods: We searched multiple databases for articles reporting outcomes following BAE for small intestinal strictures in patients with CD.

Prescribing Pattern and Effectiveness of Antihypertensives in Patients Suffering from Hypertension to Diabetes Mellitus with and without Compelling Indications in Tertiary Care Hospital.

The prevalence of hypertension (HTN) and diabetes mellitus (DM) is increasing worldwide, and their coexistence is well-documented. Managing both conditions is challenging due to shared pathophysiological mechanisms and the need to balance blood pressure (BP) control with glycemic management. The objective of this protocol was to consider the prescribing pattern and effectiveness of antihypertensive agents in hypertensive and diabetic patients, with and without compelling indications, at tertiary care hospital.

Exploring the impact of material selection on the efficacy of hot-melt extrusion.

Hot-melt extrusion (HME) has emerged as a versatile and efficient technique in pharmaceutical formulation development, particularly for enhancing the solubility and bioavailability of poorly water-soluble drugs. This review delves into the fundamental principles of HME, exploring its application in drug delivery systems. A comprehensive analysis of polymers utilized in HME, such as hydroxypropyl methylcellulose, ethyl cellulose, hydroxypropyl cellulose, and polyvinylpyrrolidone, is presented, highlighting their roles in achieving controlled drug release and improved stability.

Post Type 1 Thyroplasty Laryngocutaneous Fistula Repair at Vocal Cords Level with Deltopectoral Flap - A Rare Case Report and Review of Literature.

A 64-year-old male with left vocal cord paresis and lung cancer underwent left-sided thyroplasty, followed by chemotherapy. He developed a laryngocutaneous fistula due to silicone block extrusion. The fistula was successfully repaired using a Deltopectoral flap.

Study of Medication Reconciliation Process at the Time of Admission in the Patients of a Tertiary Care Teaching Hospital.

Introduction: Reconciliation errors are those that are considered harmful or possibly dangerous to patients; in fact, reconciliation errors significantly influence adverse drug events (ADEs) among admitted and discharged patients. Medication reconciliation facilitates the identification and prevention of medication errors and adverse drug events. Worldwide, ongoing medication management is a major source of concern for patient safety.

Diagnostic value of biochemical markers in prediction of perforation in acute appendicitis: a cross-sectional study.

Background: Acute appendicitis, despite being the most common surgery, can result in increased morbidity and mortality in the case of perforated appendicitis. Identifying a perforation early can reduce the impact on the patient. Bilirubin, C-reactive protein (CRP), and white blood cell (WBC) count have been shown to indicate perforation in appendicitis.

Non-neuronopathic Gaucher disease (Type I) in an elderly female: a case report.

Introduction And Importance: Gaucher disease is a rare autosomal recessive lysosomal storage disorder marked by a substantial reduction in beta-glucocerebrosidase activity. Historically, supportive treatments such as splenectomy and orthopedic interventions were employed, whereas recent advances have led to the approval of Enzyme Replacement Therapy (ERT) and Substrate Reduction Therapy (SRT) as therapeutic options.

Case Presentation: The authors present the case of a 61-year-old female with chronic abdominal pain, abdominal fullness, pancytopenia, and hepatosplenomegaly, all indicative of Gaucher's disease, later confirmed by histopathological examination.

Postoperative Sinus Tract: A Rare Occurrence Following Laparoscopic Cholecystectomy.

A sinus tract is a rare clinical condition characterized by a blind-ended tubular structure extending from deeper tissues to the skin, commonly occurring postoperatively, especially after gastrointestinal surgeries. Its pathogenesis often involves the breakdown of fatty tissue, pyogenic infections, or the retention of foreign bodies such as surgical implants or sutures. One notable scenario includes sinus tract formation following laparoscopic cholecystectomy due to retained gallstones.

A Global Bibliometric Analysis of the Top 100 Most Cited Articles on Early Thoracotomy and Decortication in Pleural Empyema.

Most pleural empyema cases are linked to pneumonia, a substantial fraction of patients present with empyema without any association to pneumonia. The occurrence of empyema caused by tuberculosis (TB) is increasing in regions where TB is prevalent. In May 2024, a bibliometric analysis was conducted involving the screening of 7,620 articles sourced from Google Scholar.

Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms.

Correction for 'Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms' by Madhu Shree Poddar , , 2024, , 3668-3678, https://doi.org/10.1039/D4LC00238E.

Epileptic Encephalopathy due to CACNA1A Variant: A Case Report and Diagnostic Challenges from Resource-Limited Settings.

Introduction: Epilepsy is one of the most common neurological disorders present in sub-Saharan Africa and most of these cases are underdiagnosed due to a lack of resources. Epileptic encephalopathies are a broad spectrum of seizure disorders characterized by epileptic activity itself impairing cognitive and behavioral function more than what is expected from the underlying pathology alone. Epileptic encephalopathy resulting from the CACNA1A variant is extremely challenging to treat and prognosis is poor if prompt diagnosis is not made.

Total extra-peritoneal approach to radical cystectomy with ureterostomy: A novel technique for the elderly and frail.

Objectives: Radical cystectomy with urinary diversion is the gold standard treatment for bladder cancer (high-risk/muscle invasive). The transperitoneal approach is associated with significant gastrointestinal complications like ileus. In the elderly and frail with a single functional kidney, we describe an extraperitoneal technique of radical cystectomy, with a ureterostomy, to be performed without general anesthesia.