458 results match your criteria: "Shoolini University of Biotechnology[Affiliation]"

The global shift towards renewable energy sources highlights the urgent need for sustainable hydrogen production, with photo-fermentative hydrogen evolution (PFHP) emerging as a promising solution. This review addresses the challenges and opportunities in optimizing PFHP, specifically the role of photosynthetic bacteria (PBS) in utilizing sunlight for hydrogen production. We focus on the key factors influencing PFHP, including light intensity, reactor design, substrate selection, carbon-to-nitrogen ratio, metal ions, temperature, pH, charge transfer and genetic engineering.

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The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology.

Int Immunopharmacol

January 2025

Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab 140401, India; Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates. Electronic address:

CAR T cell therapy has revolutionized how we deliver cancer treatment, most notably for hematologic cancers, by compelling T cells to recognize and kill tumor cells. Nevertheless, current obstacles to utilizing this therapy in solid tumors and overcoming cancer resistance include radicalization. This review discusses how CD95 modulation can boost CAR T cell efficacy.

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A paradigm shift in the detection of bloodborne pathogens: conventional approaches to recent detection techniques.

EXCLI J

October 2024

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India.

Article Synopsis
  • Bloodborne pathogens (BBPs) are a serious global health threat affecting both humans and animals, with notable risks for healthcare workers who face potential exposure.
  • The paper critiques traditional detection methods like PCR and ELISA, pushing for new detection technologies enhanced by advances in sensor tech.
  • It aims to educate on bloodborne infections, detailing their transmission patterns and emphasizing the need for improved management and detection strategies.
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  • The study investigates the hepatoprotective (liver-protecting) properties of a popular Ayurvedic herb by analyzing its phytochemicals using targeted metabolomics.
  • Different fractions of the herb's hydro-alcoholic extract were tested for antioxidant and protective effects on liver cells (HepG2), with the n-butanol fraction showing the best results.
  • UPLC-QTOF-MS analysis identified 17 secondary metabolites in the active fraction, some of which may inhibit the CYP2E1 enzyme, potentially reducing toxicity from APAP (acetaminophen) in liver cells.
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Polysaccharide-based biopolymeric magnetic hydrogels have garnered significant attention as effective materials for wastewater treatment due to their high adsorption capacity and environmentally friendly nature. This review examines recent advancements in the development of biopolymeric magnetic hydrogels derived from polysaccharides such as cellulose, chitosan, alginate, carrageenan, starch, and gums, with a focus on their application in removing antibiotics from contaminated water as it not only enhances adsorption performance but also simplifies separation processes after treatment, making them highly efficient for practical applications. The review aims to provide a comprehensive overview of the synthesis techniques, performance characteristics, and interaction mechanisms of these hydrogels, highlighting their renewability and suitability for large-scale water treatment.

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Hypoglycemic and antioxidant activities of L. with identification and characterization of phytocompounds.

Heliyon

November 2024

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, HP, 173229, India.

The utilization of plant-derived chemicals with anti-diabetic properties is widely promoted for its advantageous tactics in managing diabetes, as they are cost-effective and have minimal or no adverse effects. Therefore, this work investigates the medicinal plant L. leaves by extraction and bio-guided fractionation.

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Background: The global threat of multi-drug-resistant bacteria has severely limited the options available for effective antibiotics. This study focuses on the antimicrobial activity and phytochemical characterization of extracts, aiming to identify novel plant-based therapeutic agents.

Methods: specimens-leaves and inflorescence.

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Exploring the therapeutic potential of Pongamia pinnata plant extract against skin cancer: In-silico and in-vitro study.

J Ethnopharmacol

January 2025

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, P.O. Box, 9515, Jeddah, 21423, Saudi Arabia; Department of Biomedical Research, King Abdullah International Medical Research Center, P.O. Box 9515, Jeddah, 21423, Saudi Arabia.

Ethnopharmacological Relevance: Pongamia pinnata Linn belonging to the Fabaceae family, holds significance as a crucial remedy in herbal medicine.

Aim Of The Study: The present study aims to determine the anticancer and antioxidant properties of the plant extract.

Material And Methods: The methodology includes extraction of the leaf sample by soxhlet method followed by the phytochemical analysis of leaf extract.

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Quassinoids as Promising Anti-cancer Agents.

Curr Med Chem

October 2024

College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar, 31952, Saudi Arabia.

The use of current anticancer drugs is hampered by significant side effects and high costs. In the pursuit of safer, more effective, and affordable options, researchers have turned to nature as a valuable source of potential anticancer compounds. Quassinoids, a class of natural terpenoids, have garnered attention for their anticancer properties.

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Unveiling tribal treasures: myco-chemical characterization and pharmacological evaluation of an unexplored Russula  pers. species.

Antonie Van Leeuwenhoek

October 2024

Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.

During extensive field explorations of the Lateritic area in West Bengal, one remarkable wild Russuloid macrofungus, ethnically termed "Kend Patra," was collected. The species was known to enrich the diet of the local people, being considered as income source for some tribal groups. Using morphological characters and molecular analysis of this collection, provide a unique placement of the taxon in the Russula subgenus Compactae (Fr.

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Strategies to increase the secondary metabolite production, obtained from medicinal plants has been the topic of research in recent years. The symbiotic interaction between arbuscular mycorrhizal fungi and plants allows host-fungus pairings to enhance secondary metabolite synthesis. Therefore, the current study investigated the effect of inoculating two distinct AMF species discretely as well as in conjunction on the flower-derived secondary metabolites in Gomphrena globosa.

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Unlabelled: The current investigation involved the isolation of 13 endophytic fungi from sp. collected in Himachal Pradesh, India. Among these, isolate PAT-3 produced 195.

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A review of advanced bioremediation technologies for dioxin-contaminated soil treatment: Current and future outlook.

Chemosphere

October 2024

Global Centre for Environmental Remediation (GCER), University of Newcastle, Callaghan, NSW, 2308, Australia; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), University of Newcastle, Callaghan, NSW, 2308, Australia.

Polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF), namely known as dioxins, are persistent organic compounds with high toxicity. The presence of dioxins in soil is a major environmental issue worldwide, as it negatively impacts both ecosystems and human health. Thus, several advanced techniques have been applied to overcome this issue, offering promising treatment efficiency and cost-effectiveness.

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Plant pathogens cause a serious menace to food production. The diseases caused by pathogens are estimated to cause a yield loss of about 14.1 %, whereas, in India, up to 26 %.

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Recent advancements have elucidated the multifaceted roles of the Schlafen (SLFN) family, including SLFN5, SLFN11, SLFN12, SLFN13, and SLFN14, which are implicated in immunological responses. However, little is known about the roles of this gene family in relation to malignancy development. The current study aimed to explore the diagnostic and prognostic potential of Schlafen family genes in colorectal adenocarcinoma (COAD) through bioinformatics analysis.

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The resurgence of interest in amaranth and buckwheat as nutrient-rich and versatile grains has incited extensive research aimed at exploring their potential benefits for sustainable agriculture and human nutrition. Amaranth is renowned for its gluten-free nature and exceptional nutritional profile, offering high-quality proteins, fiber, minerals, and bioactive compounds. Similarly, buckwheat is recognized for its functional and nutraceutical properties, offering a plethora of health benefits attributed to its diverse array of biologically active constituents; flavonoids, phytosterols, and antioxidants.

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Biochar and biosorbents derived from biomass for arsenic remediation.

Heliyon

September 2024

International Research Centre of Nanotechnology for Himalayan Sustainability (IRCNHS), Shoolini University of Biotechnology and Management Sciences, Solan, 173229, Himachal Pradesh, India.

Global groundwater contamination by Arsenic (As) presents a grave danger to the health of living beings and wildlife, demanding comprehensive remediation strategies. This review delves into the complex landscape of arsenic remediation, encompassing its chemical forms, occurrences, sources, and associated health risks. Advanced techniques, notably biomass-derived adsorbents, emerge as promising and cost-effective solutions.

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Article Synopsis
  • Pancreatic cancer (PC) has a high mortality rate and poor prognosis despite treatment advances, highlighting the need for effective biomarkers.
  • This study used bioinformatic analyses to identify the histone lysine demethylases (KDMs) as potential therapeutic targets, finding that higher levels of KDM1A, KDM5A, and KDM5B correlated with improved patient survival.
  • Additionally, these KDMs were linked to immune cell infiltration and various cellular pathways, indicating their potential as biomarkers and targets for developing new treatment strategies against this aggressive disease.
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The rise of antimicrobial resistance (AMR) has become a serious global health issue that kills millions of people each year globally. AMR developed in bacteria is difficult to treat and poses a challenge to clinicians. Bacteria develop resistance through a variety of processes, including biofilm growth, targeted area alterations, and therapeutic drug alteration, prolonging the period they remain within cells, where antibiotics are useless at therapeutic levels.

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Twenty-two eco-friendly, novel Schiff bases were synthesized from 2,4,5-trichloro aniline and characterized by using FT-IR, H NMR, and C NMR techniques. Fungicidal activity against pathogenic fungi Sclerotium rolfsii and Rhizoctonia bataticola and insecticidal activity against the stored grain insect pest Callosobruchus maculatus of the test compounds were evaluated under control condition. All of the investigated compounds, according to the study, exhibited moderate to good antifungal and insecticidal activities.

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Article Synopsis
  • This text indicates that there is a correction to a previously published article with the DOI 10.3389/fnut.2022.929554.
  • Such corrections are typically made to address errors or clarify information in the original publication.
  • The specific details of the correction are not provided in the text itself.
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The green synthesis of copper oxide nanoparticles (CuO) mediated by crude ethanolic extract and the n-butanol fraction of Adiantum venustum represents a groundbreaking approach in nanotechnology, combining ecological sustainability with advanced functionality. This innovative method leverages the natural bioactive compounds present in A. venustum to produce CuO nanoparticles, which exhibit remarkable antioxidant, anti-inflammatory, antimicrobial, and anti-proliferative properties.

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Background: Endophytic fungi (EF) reside within plants without causing harm and provide benefits such as enhancing nutrients and producing bioactive compounds, which improve the medicinal properties of host plants. Selecting plants with established medicinal properties for studying EF is important, as it allows a deeper understanding of their influence. Therefore, the study aimed to investigate the impact of EF after inoculating the medicinal plant Perilla frutescens, specifically focusing on their role in enhancing medicinal properties.

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Article Synopsis
  • The study explored antiviral peptides (AVPs) as potential inhibitors of the SARS-CoV-2 Orf9b protein, which plays a critical role in viral infection by forming a complex with TOM70.
  • Through molecular docking and molecular dynamics simulations, two peptides, AVP1442 and AVP1896, were identified as having strong binding affinities to Orf9b, comparable to the existing Orf9b-TOM70 interaction.
  • These AVPs demonstrated stable interactions with important amino acids in Orf9b, suggesting they could be further investigated as components in drug therapies against COVID-19.
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Article Synopsis
  • Antimicrobial resistance (AMR) is a growing global health threat caused by the misuse of antibiotics, highlighting the need for innovative and sustainable solutions.* -
  • Bio-nanomaterials, made from eco-friendly precursors like biowaste and plant extracts, offer a sustainable way to combat AMR by targeting pathogens and enhancing the effectiveness of existing antibiotics.* -
  • This review discusses the potential uses of bio-nanomaterials in various health applications, their advantages in antimicrobial therapy, and the regulatory challenges they face, promoting a more sustainable approach to healthcare.*
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