1,556 results match your criteria: "Shizuoka Hospital.[Affiliation]"

Article Synopsis
  • - The study analyzed the impact of using an aspirin-free strategy versus dual antiplatelet therapy (DAPT) in patients undergoing coronary intervention while on oral anticoagulation (OAC).
  • - Among nearly 6,000 patients, the outcomes showed no significant difference in major bleeding events between the two strategies, regardless of OAC use.
  • - However, there was a slightly higher risk of cardiovascular events with the aspirin-free approach in patients taking OAC, suggesting potential concerns about this strategy's safety in high-risk groups.
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  • In a study analyzing Japanese patients' attitudes towards ultra-hypofractionated (UHF) radiation therapy for early-stage breast cancer, it was found that this treatment is becoming the standard in Europe due to its effectiveness and low risk of complications.
  • The survey, conducted across 13 facilities, involved 247 patients who rated their enthusiasm for UHF on a scale of 0-10, with 69% rating it 6 or higher and 45% giving it a perfect score.
  • Most patients prioritized treatment efficacy (89%), while breast appearance after treatment was the least important factor for 53% of respondents, indicating a strong support for the UHF approach.
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  • Thrombosis in myeloproliferative neoplasms (MPNs) poses significant clinical challenges, requiring tailored management based on patient risk factors.
  • A study analyzed data from a multi-center research effort (JSH-MPN-R18) to identify blood count parameters predictive of thrombosis in patients with essential thrombocythemia (ET) and polycythemia vera (PV).
  • Findings revealed that higher neutrophil ratios and absolute neutrophil counts (aNeu) in ET and PV patients correlates with thrombotic events, suggesting the need for further research on genetic factors like JAK2 mutations.
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Novel and characteristic radiological features of neurosyphilis: a case series.

BMC Neurol

July 2024

Department of Radiology, Japanese Red Cross Society Shizuoka Hospital, 8-2 Otemachi, Aoi Ku, Shizuoka City, Shizuoka Prefecture, 420- 0853, Japan.

Article Synopsis
  • Treponema pallidum can invade the CNS early in syphilis infection, often leading to misdiagnosis due to its wide range of symptoms that mimic other serious conditions.
  • Three case studies highlight distinct radiological manifestations of neurosyphilis: optic nerve involvement in an HIV-positive male, a misdiagnosed pregnancy case originally thought to be an acoustic neuroma, and a young male with symptoms resembling temporal arteritis.
  • The cases stress the importance of considering syphilis in diagnoses, as timely identification and treatment are crucial given the rising rates of this infection and its complex presentations.
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Background: Variations in sac shrinkage (SS) are noted between endovascular aneurysm repair for abdominal aortic aneurysm (AAA) and fenestrated endovascular aneurysm repair for short neck AAA. These variations may originate from difference in the geometry and length of proximal sealing, which influences the quality and durability of the seal. This study aimed to explore the disparities in aneurysm exclusion and sac remodeling across these 2 scenarios.

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  • The study investigates the risks and survival outcomes for non-small cell lung cancer (NSCLC) patients with pre-existing autoimmune disorders (AIDs) undergoing immune checkpoint blockade (ICB) therapy.
  • Conducted across 20 centers in Japan, it analyzed data from 229 patients, revealing that 25.4% experienced AID flare-ups while receiving ICB, particularly those diagnosed with NSCLC within a year of their AID diagnosis.
  • The results suggest that ICB therapy not only extends survival but also emphasizes its potential benefit for NSCLC patients with AIDs, despite some associated immune-related adverse effects.
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  • - A new prognostic model was developed to predict cancer-specific survival (CSS) for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC) using data from 1,092 Japanese patients treated between 2014 and 2020.
  • - Key factors for predicting CSS included disease severity, liver metastasis, certain lab results, and primary tumor characteristics, leading to significant differences in 5-year CSS rates among low-risk (86%) and high-risk (22%) groups.
  • - This model displayed high accuracy and reproducibility, and it may help tailor treatment approaches for patients with mHSPC, especially in determining the intensity of therapies needed.
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Purpose: This study aimed to compare subjective allergic conjunctivitis symptoms and anti-allergic eye drop use patterns between antihistamine-releasing contact lens users and daily disposable soft contact lens users during Japan's hay fever season.

Methods: This web-based retrospective cohort study included daily disposable soft contact lens or antihistamine-releasing contact lens users with a history of seasonal allergic conjunctivitis who regularly used daily disposable soft contact lenses since the previous year. The total ocular symptom score (range 0-20) based on 5-item questionnaire scores and time from the start of the hay fever season to the initiation of anti-allergic eye drop treatment were compared between antihistamine-releasing contact lens users and daily disposable soft contact lens users.

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  • Current guidelines suggest using either DOACs or warfarin for patients with atrial fibrillation who have a bioprosthetic valve, but research on elderly patients (≥80 years) in this context is limited.
  • A study analyzed data from 752 patients, revealing that those aged ≥80 had a significantly higher risk of adverse outcomes than younger patients, with a hazard ratio of 2.04.
  • The findings indicate that both DOACs and warfarin have comparable efficacy and safety in managing elderly patients with bioprosthetic valves and atrial fibrillation.
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Purely Endoscopic Evacuation of Intracranial Hematomas.

Adv Tech Stand Neurosurg

July 2024

Department of Pathology, Chub Rosai Hospital, Nagoya, Japan.

Cerebral hemorrhage is a frequent disease and one of the main causes of disabilities. Even in the case of cerebral hemorrhage, if there were a treatment that would improve the functional prognosis, the benefits would be immeasurable. Although there are limited reports with a high level of evidence in past studies, it has been found that surgery can be effective if a large amount of hematoma can be removed in a minimally invasive manner.

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A 66-year-old man developed exertional dyspnea. The patient had undergone total arch replacement for a dissecting aortic arch aneurysm at the age of 53 and conservative treatment for myocardial infarction at the age of 60. Several imaging studies revealed a giant pseudoaneurysm that likely originated from a true ventricular aneurysm.

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Background: Previous studies have shown shorter duration of general anesthesia in smokers but it is unclear in regional anesthesia among smokers. We investigated the association between smoking status and the duration of regional anesthesia.

Methods: A total of 77 patients with a mean age of 47.

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Acute aortic dissection during scuba diving.

Undersea Hyperb Med

July 2024

Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University.

Article Synopsis
  • * Despite a normal ECG and ultrasound findings, doctors suspected acute coronary syndrome, leading to the patient’s transport to the hospital, where a flap in the ascending aorta was detected.
  • * He was diagnosed with Stanford type A aortic dissection after CT imaging and underwent emergency surgery, marking the first reported case of such a condition potentially linked to scuba diving activities.
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Background: Initial hemodynamic status in patients with acute pulmonary embolism (PE) concerns their acute clinical outcomes. Nevertheless, the characteristics of initial hemodynamic dysfunction and acute mortality in PE patients with active cancer is still controversial.

Methods: We analyzed the data of 1715 PE patients in the COMMAND VTE Registry to compare initial hemodynamic dysfunction, management strategies, and mortality outcomes at 30 days after PE diagnosis between patients with and without active cancer (N = 393 and N = 1322).

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poisoning due to calcium oxalate needle crystals in Japan.

J Rural Med

July 2024

Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Japan.

Article Synopsis
  • The investigation focused on damage cases caused by a specific plant species in Japan, particularly from a hospital in Shizuoka Prefecture and reviewed previous reports.
  • The plant contains calcium oxalate crystals, leading to severe poisoning symptoms like oral pain, nausea, and potential asphyxia, often confused with Satoimo due to its similar appearance.
  • Immediate action includes spitting out the plant and rinsing the mouth; medical intervention may be needed for airway management if asphyxiation is possible.
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Article Synopsis
  • Current guidelines suggest avoiding anticoagulation after PCI for acute coronary syndrome (ACS), but this recommendation lacks strong evidence.
  • In a study analyzing outcomes of patients with ACS who did or did not receive post-PCI heparin, those receiving heparin had a significantly higher risk of bleeding and a slightly increased risk of cardiovascular events.
  • The use of post-PCI heparin in ACS patients was common, but it was linked to increased bleeding without demonstrating any clear benefit in reducing serious cardiovascular outcomes.
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Objective: To evaluate the healing outcome of a platelet-rich plasma (PRP) gel prepared using TKKT01 (a wound care device to prepare the PRP gel) in patients with hard-to-heal diabetic foot ulcers (DFUs) and who showed an inadequate response to ≥4 weeks of standard of care (SoC).

Method: This open-label, single-arm, multicentre study was conducted in 15 centres in Japan. Eligible patients received PRP gel treatment twice a week for eight weeks, followed by a final evaluation after the completion of week 8 (day 57).

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Finite element analysis of mechanical stress in a cementless tapered-wedge short stem in the varus position.

J Orthop Surg Res

July 2024

Department of Orthopedic Surgery (Ohashi), School of Medicine, Toho University, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.

Background: In recent years, the use of tapered-wedge short stems has increased due to their ability to preserve bones and tendons. Surgical techniques occasionally result in a varus position of the stem, which is particularly pronounced in short stems. Although the varus position is not clinically problematic, there are reports of an increased incidence of stress shielding and cortical hypertrophy.

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Article Synopsis
  • The PE-SARD bleeding score was developed to predict early major bleeding in patients with pulmonary embolism (PE) but has not been fully validated externally.
  • A study using data from the COMMAND VTE Registry involving 2,781 acute PE patients categorized them into high, intermediate, and low-risk groups based on this score, revealing a clear increase in bleeding rates with higher risk scores.
  • The results indicated the score has modest effectiveness in predicting bleeding risk overall, with better performance in patients without active cancer.
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Background: The Mt FUJI study was a multicenter, prospective, randomized, single-blind, controlled trial comparing delivery catheter-based and stylet-based right ventricular (RV) lead placement at the RV septum. This study extended the follow-up duration to 1 year after implantation.

Methods: Seventy patients with pacemaker indications for atrioventricular block were randomly assigned to the delivery catheter and stylet groups.

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The misdiagnosis of headache disorders is a serious issue, and AI-based headache model diagnoses with external validation are scarce. We previously developed an artificial intelligence (AI)-based headache diagnosis model using a database of 4000 patients' questionnaires in a headache-specializing clinic and herein performed external validation prospectively. The validation cohort of 59 headache patients was prospectively collected from August 2023 to February 2024 at our or collaborating multicenter institutions.

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  • Recent studies indicate that calcified nodules (CN) in patients with acute coronary syndrome (ACS) are linked to worse health outcomes.
  • The study involved 695 ACS patients and found that those with OCT-defined CN were typically older and had higher incidences of diabetes, hemodialysis, and severe heart failure compared to those without CN.
  • Key predictors for the presence of OCT-CN included age, hemodialysis, and Killip Class III/IV heart failure, suggesting that these factors could indicate increased lesion severity and poorer prognosis for ACS patients.
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